! NEW RESEARCH WORK !
A recent publication
by Abalo R, Chen C, Vera G, Fichna J, Thakur GA, López-Pérez AE, Makriyannis A, Martín-Fontelles MI, Storr M in "Neurogastroenterol Motil." highlights the merits of using Bioseb's Electronic Von Frey
: In vitro and non?invasive in vivo effects of the cannabinoid?1 receptor agonist AM841 on gastrointestinal motor function in the rat
New EVF Software with embedded video
Electronic Von Frey: New stand
Bioseb’s new Electronic Von Frey unit EVF4 is an easy-to-use instrument allowing you to quickly determine the mechanical pain sensitivity threshold in rodents (both rats and mice).
This value can be measured in one single application of the test, and offers a high accuracy and repeatability. The same analgesia equipment will enable you to carry out animal and human studies (clinical studies: only for research protocols while the agreement for Medical CE mark is in process). The resolution of the screen is 0,1 gram.
Sensibility thresold result is displayed on a large backlighted screen. The electronic instrument does not present any temperature or hygrometry drift, which used to be an issue with the manual version of the filaments.
Thanks to 16 years in marketing electronic Von Frey instruments, Bioseb has designed what will be the next standard for reflex testing on freely moving rodents, now with embedded video!
The electronic model of Von-Frey filament combines ease-of-use and rapidity for the determination of the mechanical sensitivity threshold in rodent.
Basically, a tip is applied against the central edge of the animal hind paw. Paw withdrawal caused by the stimulation is registered as a response. The corresponding force applied is recorded by the system and displayed on the large backlighted screen of the Von-Frey unit with a resolution of 0.1 grams. A different tip is used for rat (hard plastic tip) and mice (elastic spring tip).
Differently to the procedure using classical Von-Frey filaments, the threshold value can be obtained in only one test, and in a highly reproducible manner. A foot-switch is provided to carry out rapid hands-free experiments. BIO-CIS software can be used to automatically record the results on a PC through a RS 232 port.
The new EVF4 features several new improvements such as:
• Embedded video!
Now the paw is viewed from the screen of a computer or tablet where the plantar surface can be seen in HD. More accurate, this new method is much comfortable for the user and so generates better data
• New, non corrosive tips
that are gold-plated and mounted on precision springs that absorb the force of impact and reduce the "touch-on" effect. Spring based tips increase the accuracy of the measurement over their range of bending.
• A lighter stimulator
wand with the center of gravity placed more centrally for more precise movement and better control of the increase in force.
• The validation button
is now placed right on the stimulator wand, so the operator can more readily store what is considered to be a good withdrawal measurement.
And of course, all the classical features that made our Electronic Von Frey instrument a must for all your research work on pain and nociception:
• Large backlighted LCD screen displaying current and peak value
• Statistical functions: average value and standard deviation are computed for each subject
• Stand-alone instrument: internal memory allows the storing of up to 100 values, which may be transfered to a PC using our optional software
A few options for easier operations
• A patient switch allows to freeze the displayed value when the threshold is reached
• An RS232 interface allows to transfer the displayed value on to a computer
• Touchscreen tablet for video display
• Our BIO-CIS software allows to write directly on EXCEL7 the value measured (PC with Windows 7 or higher) thus you avoid transcription errors, and get instant report
Domains of application
• Post-operative pain
• Phantom pain
• 10 disposable plastic tips
• 1 spring tip for thresholds between 0 and 10 gramms
• Footswitch to reset the display to zero
• Carrying case for transport