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AUTOMATIC FOOT MISPLACEMENT APPARATUS
(Model: BIO-FMA)
A unique, automatic apparatus for the detailed and objective modeling of walking and walking disorders in mice and/or rats, with respect to motor and psychomotor skills and cognition. An innovative and operator-independent solution for studies on myopathy, ataxia, alcoholism, Parkinson’s and Huntington’s disease, and much more.

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  • IGBMC Strasbourg, France
  • FACULTE DE PHARMACIE Marseille, France
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'Mouse on a foot misplacement apparutus, by Bioseb
Mouse on the FMA
The Foot Misplacement Apparatus (FMA) is a unique system to objectively detect gait or walking disorders, abnormalities of coordination and motor or reflex problems in small rodents (rat or mouse) in a highly accurate way, by recording the number, position and duration of errors (missteps or paws’ slips as well as tail errors) of an animal walking in an opaque corridor on an horizontal ladder towards a dark compartment.

The ladder bars can be removed to increase the difficulty of the exercise or create traps, and two sets of 77 infrared sensors are placed above and below the ladder to detect the animal’s movement and any paw misplacements, knowing that the number of errors increases with the animals motor deficit and the difficulty of the required task.

The instrument allows you to quantify the recovery of sensorimotor activity, and is of particular interest for studies on myopathy, ataxia, alcoholism, Parkinson’s and Huntington’s disease, recovery from brain or spinal cord injuries, and much more !

Operating principle

2 compartments (a departure and an arrival box) are located on each side of a long horizontal ladder encased in a corridor. The arrival box is a black compartment that attracts the animal, which walks towards the end of the ladder. On each side of the rungs, infra-red beams and sensors ( 77 sets both above and below the ladder) detect the rodent’s movement and are used to recognize and record the exact position and duration errors in motor control (missteps or paw slips between any 2 bars).

Furthermore, the Foot Misplacement system is able to differentiate between fore and hind paws. The space between the rungs can be adjusted to increase the difficulty, and one or more bars can be removed to create traps.

Animals are usually tested across 5 regular runs.

The corridor is removable for an easy and fast cleaning. Rat and mouse corridors are interchangeable to allow you to test small and large rodents (rats or mice) on the same apparatus. One corridor for either rat or mouse is included with the instrument - the other version can be ordered separately.

Key features

• Fully automatic, operator-independent
• Aversive starting box with cold white blinking light
• Interchangeable rat/mouse corridors on the same instrument
• Two sets of 77 infrared sensors provide high accuracy, and great reliability
• Self-powered by USB port from PC
Domains of application

• Functional, toxicological, and genetic models
• Studies on toxicosis, alcoholism
• Resarch on myopathy and ataxia
• Research on Parkinson's and Huntington’s disease
• Recovery from brain or spinal cord injuries

Dedicated Software

Bioseb’s Foot Misplacement Apparatus software records data collected by the sensors and determines parameters for all errors from paws (both front and hind) and tail.

It generates a distinct results file for each animal, which is easily exportable into Excel format. The software also filters sensors information, allows adjustment of the misplacement duration detection, automatically sorts out errors from front legs, back legs and tail and directly calculates the time/report ratio of the course and error rate.

Following recorded parameters are included into the detailed experimental report :
• Total crossing time
• Input and output latency time
• Number of errors (missteps or slips)
• Type of errors (front paws, hind paws or tail)
• Duration of each error
• Position of each error

Screenshots from the foot misplacement system software, by Bioseb Screenshots from the foot misplacement system software, by Bioseb
Screenshots from the foot misplacement system software

THE INFORMATION IN THIS WEB SITE AND IN LINKED PAGES AND DOCUMENTS IS PROVIDED "AS IS" AND DOES NOT CREATE ANY EXPRESS OR IMPLIED WARRANTY ABOUT BIOSEB OR ITS PRODUCTS OR SERVICES.

Information published on this Web Site as well as services, product specifications, availability and prices are subject to change without notice. BIOSEB may also make improvements and/or changes in the products and/or the programs described in this Web Site at any time without notice.

BIOSEB has made reasonable efforts to verify that the information in this Web site was accurate when first published. Such information may contain errors or omissions, however, and it is subject to change without notice. Bioseb does not undertake to update this information to include any such changes or to correct errors or omissions. Bioseb assumes no responsibility for any use of the information in this Web site or for any infringement of patents or other rights of third parties that may result. Certain information may be country-specific and may not apply in all countries.

Acquisition speed 10 ms
Number of sensors 154
Dimensions 124 x 28 x 20 (L x W x H cm)
Corridor width 80 mm for rats and 50 mm for mice (1 corridor included)
Space between bars 1/3 cm (customisable)
Aversive starting box using cool white light, adjustable by software
Bar height Adjustable bar height with respect to error sensors
Power supply CE 15-V standard charger
Connector USB compliant

Model:
BIO-FMA
Automatic Foot misplacement apparatus (Modif.)
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Accessories :
BIO-FMA-CORR
Additionnal corridor for mice or rats (Modif.)
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Bioseb - In Vivo Research Instruments
Phone worldwide : +33 442 344 360 - USA/Canada : (727) 521-1808
e-Mail : Worldwide: info@bioseb.com - USA/Canada: sales@eb-instruments.com