! NEW RESEARCH WORK !
A recent publication
by Urien L, Gaillard S, Lo Re L, Malapert P, Bohic M, Reynders A, Moqrich A in "Scientific Reports" highlights the merits of using Bioseb's Thermal Gradient Test
: Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain.
The Thermal Gradient Test has been described in Moqrich et al. 2005, and is one of the very few thermal nociception tests to be operator independant on freely moving rodents
(mice and rat). A continuous temperature gradient (-4 to 65°C) is established over a 120 cm long base plate, on which the animal is free to walk. After the exploration period the rodent (mouse or rat) shows a distinct zone preference
, or comfort zone.
Bioseb has defined an automated instrument for your research on analgesia and nociception (especially suitable for research on alodynia), with a temperature gradient stable over the surface and over time, allowing to identify the prefered temperature zone. Two instruments models will test independantly and simultaneously 2 mice or small rats (1 adult rat).
The accompanying software, coupled to a video camera, displays for each animal the time spent per time period in each temperature zone, together with overall travelled distance.
The encrypted datas and the video images are recorded synchroneously in real time during the nociception experiments. This allows the operator to replay and check the animal behaviour at any time and remotely, and also to comply with Good Laboratory Practice (GLP).