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STARTLE AND FEAR SYSTEM
(Model: LE116 - For rats and mice)
A polyvalent system for conducting both fear conditioning and startle reflex experiments

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! NEW RESEARCH WORK ! A recent publication by Duclot F, Perez-Taboada I, Wright KN, Kabbaj M in "Neuropharmacology." highlights the merits of using Bioseb's Startle and Fear System: Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine

Prediction of individual differences in fear response by novelty seeking, and disruption of contextual fear memory reconsolidation by ketamine
Duclot F, Perez-Taboada I, Wright KN, Kabbaj M
Department of Biomedical Sciences, Florida State University, Tallahassee, FL 32306, United States; Program in Neuroscience, Florida State University, Tallahassee, FL 32306, United States.
Published in "Neuropharmacology." (2016-06-22)


Only a portion of the population exposed to trauma will develop persistent emotional alterations characteristic of posttraumatic stress disorder (PTSD), which illustrates the necessity for identifying vulnerability factors and novel pharmacotherapeutic alternatives. Interestingly, clinical evidence suggests that novelty seeking is a good predictor for vulnerability to the development of excessive and persistent fear. Here, we first tested this hypothesis by analyzing contextual and cued fear responses of rats selected for their high (high responders, HR) or low (low responders, LR) exploration of a novel environment, indicator of novelty seeking. While HR and LR rats exhibited similar sensitivity to the shock and cued fear memory retention, fewer extinction sessions were required in HR than LR animals to reach extinction, indicating faster contextual and cued memory extinction. In a second part, we found an effective disruption of contextual fear reconsolidation by the N-methyl-d-aspartate receptor antagonist ketamine, associated with a down-regulation of early growth response 1 (Egr1) in the hippocampal CA1 area, and up-regulation of brain-derived neurotrophic factor (Bdnf) mRNA levels in the prelimbic and infralimbic cortices. Altogether, these data demonstrate a link between novelty seeking and conditioned fear extinction, and highlight a promising novel role of ketamine in affecting established fear memory.

Presentation

The "Startle and Fear" system is a polyvalent system taking advantage of the same equipment for conducting both fear conditioning and startle reflex experiments, regardless the animal is a rat or a mouse.


Operating principle

Basically, the "Startle and Fear" system allows the recording and the analysis of the signal generated by the animal movement through a high sensitivity Weight Transducer system. The analogical signal is transmitted to the STARTLE or FEAR software through the load cell unit for recording purposes and posterior analysis in terms of activity/immobility (fear conditioning) or startle response characterization (startle reflex). Two additional control units allow setting the frequency and the amplitude of the sound (pre-pulse, pulse, background noise) as well as the intensity of the shock.

The "Startle and Fear" cage is made with black methacrylate walls and a transparent frond door. In fear conditioning experiment, the walls, cover and floor can be of different material or colour. Moreover, a transparent cylinder can be placed into the experimental chamber in order to modify the contextual spatial perception of the subject during the test phase.


Parameters Measured

All the parameters given by the Startle or fear software, i.e.:
• Time of experiment at which each activity event has occured (fear conditioning)
• Duration of each inactivity event (fear conditioning)
• Latency until the maximum amplitude of startle response (startle reflex)
• Duration of the startle response (startle reflex)
• Latency until the begining of the startle response (startle reflex)
• Average of the startle response (startle reflex) Accessories Startle and Fear


Key features

• Combined system for Startle/Freezing and Rat/Mice
• Unmatched sensitivity for mice
• One same enclosure for either rat or mouse
• Same weight transducer platform regardless the weight of the animal (15-500g)
• Hightly flexible protocol editor
• Accurate and entirely traceable data
• Tone frequency and intensity controlled by software
• Easily removable tray
• Different spatial context configurations available for fear conditioning paradigms
• No PCI cards required


Supplied with

• Experimental Chamber
• Stimulation Unit
• Sound Proof Box (LE26)
• Weight cell amplifier (LE111)
• Audio Generator (LE118)


Options

• Mouse/Rat holder for Startle Reflex (LE117M or LE117R)
• Shock Generator (LE10026)
• StartWin Software to control up to 8 Stimulation units


Publications (Click on an article to show details and read the abstract)


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Soundproof box dimensions 670 (W) x 530 (D) x 550 (H) mm
Cage dimensions 250 (W) x 250 (D) x 250 (H) mm
Material Composition Methacrylate, aluminium, stainless steel
Maximum number of stations 8 stations connected to a PC
Sound frequency and amplitude Prepulse/Pulse: adjustable from 200 to 10000 Hz Max 120 dB,
White noise from 60 to 120 dB
Certifications CE Compliant
Power Supply 110V/220V, 50/60Hz

Model:
LE116
Startle and Fear System (Modif.)
For rats and mice Contact us

Related products:
STARTLE
Contact us
FREEZING
Contact us

Accessories :
LE117M
Restrainer for Startle Reflex (Modif.)
For Mouse Contact us
LE117R
Rat restrainer for Startle Reflex (Modif.)
For Rat Contact us
LE111
Load Cell Amplifier (one for each LE116) (Modif.)
Contact us
LE10026
Shock generator with scrambler. 0-2 mA output (Modif.)
Contact us
LE117MM
Mouse Restrainer for Startle Reflex (> 50 g) (Modif.)
Contact us
LE100501M
Shockable grid for LE1005. Space between bars: 6 mm (Modif.)
Contact us
Print version

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