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SPONTANEOUS ACTIVITY WHEELS
(Model: BIO-ACTIVW-M - For Mice)
The spontaneous activity wheel for mice is an easy way to quantify rodents' spontaneous activity in their home cage environment - particularly well suited for the mouse. The embedded electronics perform a wide range of measurements, including: wheel turns, average/min/max speed, acceleration, total time in the wheel, number of accesses to the wheel, time on the wheel, etc. A useful tool for studies on Drug screening, Phenotyping and Neuromuscular diseases. Now with a software-independent LCD display, and a brand-new software controlling up to 64 wheels!

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  • SWISS FEDERAL INSTITUTE OF TECHNOLOGY Lausanne, Suisse
  • INSERM Paris, France
  • IPSEN Les Ulis, France
  • UNIVERSITY OF GENEVA Geneve, Suisse
  • CNRS Angers, France
  • CHILDRENS HOSPITAL Boston, France
  • PHARMACOLOGY GRANADA UNIVERSITY GRANADA, SPAIN
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! NEW RESEARCH WORK ! A recent publication by E. Cobos, N. Ghasemlou, D. Araldi, D. Segal, K. Duong et al. in "Pain" highlights the merits of using Bioseb's Spontaneous activity wheels: Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia.

Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia.
E. Cobos, N. Ghasemlou, D. Araldi, D. Segal, K. Duong et al.
Children's Hospital Boston, F.M. Kirby Neurobiology Center, Boston, USA.
Published in "Pain" (2012-04-30)


Inflammatory pain impacts adversely on the quality of life of patients, often resulting in motor disabilities. Therefore, we studied the effect of peripheral inflammation induced by intraplantar administration of complete Freund's adjuvant (CFA) in mice on a particular form of voluntary locomotion, wheel running, as an index of mobility impairment produced by pain. The distance traveled over 1 hour of free access to activity wheels decreased significantly in response to hind paw inflammation, peaking 24 hours after CFA administration. Recovery of voluntary wheel running by day 3 correlated with the ability to support weight on the inflamed limb. Inflammation-induced mechanical hypersensitivity, measured with von Frey hairs, lasted considerably longer than the impaired voluntary wheel running and is not driving; therefore, the change in voluntary behavior. The CFA-induced decrease in voluntary wheel running was dose-dependently reversed by subcutaneous administration of antiinflammatory and analgesic drugs, including naproxen (10-80 mg/kg), ibuprofen (2.5-20mg/kg), diclofenac (1.25-10mg/kg), celecoxib (2.5-20mg/kg), prednisolone (0.62-5mg/kg), and morphine (0.06-0.5mg/kg), all at much lower doses than reported in most rodent models. Furthermore, the doses that induced recovery in voluntary wheel running did not reduce CFA-induced mechanical allodynia, indicating a greater sensitivity of the former as a surrogate measure of inflammatory pain. We conclude that monitoring changes in voluntary wheel running in mice during peripheral inflammation is a simple, observer-independent objective measure of functional changes produced by inflammation, likely more aligned to the global level of pain than reflexive measures, and much more sensitive to analgesic drug effects.
Activity wheel for rodent, by Bioseb
Activity wheel for rodent, by Bioseb
Presentation

Our new Spontaneous Activity Wheel is an easy and cost-efficient way to quantify rodents' spontaneous activity in their home cage environment (type IIL and III cages), and can be used for both mice and rats (two different models available).

The system allows you to record the parameters pertaining to the voluntary exercise of the animal, which can freely decide upon its timing and intensity. Monitoring and recording typically takes place over extended periods of time (several days or weeks) in order to analyze the differences in behavior and exercising patterns induced by drugs or surgical manipulation. Though the analysis focuses on spontaneous activity, it is highly relevant for long-term studies on alterations of the circadian rhythm.

Measurements include the distance run both ways, the number of wheel turns, average/min/max speed, acceleration, total time in the wheel, and can be displayed in statistical form or sorted by time periods. Periods can be customized for facilitating further analysis.

An ideal tool for studies on Drug screening, Phenotyping and Neuromuscular diseases.

Operating principle

New embedded LCD screen of Bioseb's Spontaneous activity wheel for rodent
New embedded LCD screen:
Automatic counter
Highly reliable sensors offering an excellent angular resolution (22°) as well as time resolution (0,1 seconds for up to 64 cages) accurately records the animal's spontaneous exercising behavior, even allowing the study of the mouse’s acceleration and power pattern.

A clever design includes a coding disk as well as an LCD screen counter and Infrared sensors, as well as a “standard” cage construction from stainless steel and perpex ensures that the system is both durable and easy to use and maintain in the daily laboratory operation.

A complete digital solution based on Bioseb’s ACTIVW-SOFT software allows you to monitor up to 64 cages simultaneously via an external connection to the PC USB port (up to 5 m between cage and PC).

Key features

• Allow monitoring of spontaneous activity
• High angle and time resolution allows recording of acceleration pattern
• Practical and sturdy design is adapted for durable use and easy cleaning
• Software allows monitoring of up to 64 wheels simultaneously
• Cost-effective setting not requiring the presence of an operator (unlike treadmills)
• Now with an LCD display!
• Works for both rats and mice
Domains of application

• Drug screening
• Phenotyping
• Neuromuscular diseases
• Parkinson disease
• Duchenne muscular dystrophy

Dedicated software ACTIVW-SOFT

Our ACTIVW-SOFT software offers a complete solution to manage mice groups, allowing you to import/export and edit groups, as well as setup delayed acquisition start, and pause recording (for instance during cage cleaning). Data is recorded at 15Hz, then integrated at 1Hz, and can be re-compiled in analytical mode on an adjustable period of 1 sec up to 999 minutes.

Bioseb's dedicated ACTIVW-SOFT lets you visualize data in a convenient control panel, for each wheel, or for a group of wheels.

Bioseb's dedicated software for rodents' activity wheels allows customized settings for the data acquisition averaging periods (from 1second), the duration of recording, the latency period prior to account for Wheel movement, etc. Those settings can be defined according the user's needs.

Results include:
• A data file computed per period with informations of speed, acceleration, wheel rotations...
• Total time of the animal in the wheel with break down in number of rotating occurences (using the preset latency time)
• Outputs: via txt file in Microsoft Excel format.


Publications (Click on an article to show details and read the abstract)

PAIN
- Inflammatory pain -
Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia. (2012)
Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia.
E. Cobos, N. Ghasemlou, D. Araldi, D. Segal, K. Duong et al.
Children's Hospital Boston, F.M. Kirby Neurobiology Center, Boston, USA.
Published in "Pain" (2012-04-30)

Inflammatory pain impacts adversely on the quality of life of patients, often resulting in motor disabilities. Therefore, we studied the effect of peripheral inflammation induced by intraplantar administration of complete Freund's adjuvant (CFA) in mice on a particular form of voluntary locomotion, wheel running, as an index of mobility impairment produced by pain. The distance traveled over 1 hour of free access to activity wheels decreased significantly in response to hind paw inflammation, peaking 24 hours after CFA administration. Recovery of voluntary wheel running by day 3 correlated with the ability to support weight on the inflamed limb. Inflammation-induced mechanical hypersensitivity, measured with von Frey hairs, lasted considerably longer than the impaired voluntary wheel running and is not driving; therefore, the change in voluntary behavior. The CFA-induced decrease in voluntary wheel running was dose-dependently reversed by subcutaneous administration of antiinflammatory and analgesic drugs, including naproxen (10-80 mg/kg), ibuprofen (2.5-20mg/kg), diclofenac (1.25-10mg/kg), celecoxib (2.5-20mg/kg), prednisolone (0.62-5mg/kg), and morphine (0.06-0.5mg/kg), all at much lower doses than reported in most rodent models. Furthermore, the doses that induced recovery in voluntary wheel running did not reduce CFA-induced mechanical allodynia, indicating a greater sensitivity of the former as a surrogate measure of inflammatory pain. We conclude that monitoring changes in voluntary wheel running in mice during peripheral inflammation is a simple, observer-independent objective measure of functional changes produced by inflammation, likely more aligned to the global level of pain than reflexive measures, and much more sensitive to analgesic drug effects.

CROSS-DISCIPLINARY SUBJECTS
- Phenotyping -
The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene (2015)
The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene
Luna-Sánchez M, Díaz-Casado E, Barca E, Tejada MÁ, Montilla-García Á, Cobos EJ, Escames G, Acuña-Castroviejo D, Quinzii CM, López LC
Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain Centro de Investigación Biomédica, Instituto de Biotecnología, Parque Tecnológico de Ciencias de la Salud, Granada, Spain.
Published in "EMBO Mol Med." (2015-03-23)

Primary coenzyme Q10 (CoQ10) deficiency is due to mutations in genes involved in CoQ biosynthesis. The disease has been associated with five major phenotypes, but a genotype-phenotype correlation is unclear. Here, we compare two mouse models with a genetic modification in Coq9 gene (Coq9(Q95X) and Coq9(R239X)), and their responses to 2,4-dihydroxybenzoic acid (2,4-diHB). Coq9(R239X) mice manifest severe widespread CoQ deficiency associated with fatal encephalomyopathy and respond to 2,4-diHB increasing CoQ levels. In contrast, Coq9(Q95X) mice exhibit mild CoQ deficiency manifesting with reduction in CI+III activity and mitochondrial respiration in skeletal muscle, and late-onset mild mitochondrial myopathy, which does not respond to 2,4-diHB. We show that these differences are due to the levels of COQ biosynthetic proteins, suggesting that the presence of a truncated version of COQ9 protein in Coq9(R239X) mice destabilizes the CoQ multiprotein complex. Our study points out the importance of the multiprotein complex for CoQ biosynthesis in mammals, which may provide new insights to understand the genotype-phenotype heterogeneity associated with human CoQ deficiency and may have a potential impact on the treatment of this mitochondrial disorder.


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Standard Cage in Polycarbonate type IIL
Cover and Wheel in Stainless steel
Local display LCD Screen: CW/CCW/Total/mouse name
Overall Dimensions L x l x h = 35 x 20 x 13 cm
Wheel Dimensions Diameter : 23 cm, Lane width : 5cm
Sampling speed 15 Hz
Angular Resolution 22°
Min period 1 sec
Power 240 / 110 V, 50 / 60 Hz
Connexion requires 2 USB Ports
Software W7 / W8 64 bits

Model:
BIO-ACTIVW-M
Spontaneous activity wheels (Modif.)
For Mice Contact us

Related products:
BIO-ACTIVW-R
For Rats Contact us
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