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SPATIAL PLACE PREFERENCE TEST
(Model: LE895)
An experimental chamber developed with the aim to optimise place preference and aversion studies in small laboratory animals, especially mice, with a ground-breaking innovation: the possibility to combine a new additional spatial dimension to allow the animal differentiate the different compartments in a more discriminative manner.

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! NEW RESEARCH WORK ! A recent publication by E. Barbier, H. Houchi, V. Warnault, O. Pierrefiche, M. Daoust et al. in "Neuroscience" highlights the merits of using Bioseb's Spatial place preference Test: Effects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in long evans rats

Effects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in long evans rats
E. Barbier, H. Houchi, V. Warnault, O. Pierrefiche, M. Daoust et al.
Université de Picardie Jules Verne, Groupe de Recherche sur l'alcool et les Pharmacodépendances, Equipe région INSERM 24 (ERI24), Amiens, France.
Published in "Neuroscience" (2009-06-30)


An important factor that may influence addiction liability is exposure during the early life period. Exposure to ethanol, early in life, can have long-lasting implications on brain function and drugs of abuse response later in life. In the present study we investigated the behavioral responses to ethanol and to psychostimulants in Long Evans rats that have been exposed to pre- and postnatal ethanol. Since a relationship between heightened drug intake and susceptibility to drug-induced locomotor activity/sensitization has been demonstrated, we tested these behavioral responses, in control and early life ethanol-exposed animals. The young adult male and female progeny were tested for locomotor response to alcohol, cocaine and d-amphetamine. Sedative, rewarding effects of alcohol and alcohol consumption were measured. Our results show that early life ethanol exposure behaviorally sensitized animals to subsequent ethanol and psychostimulants exposure. Ethanol-exposed animals were also more sensitive to the hyperlocomotor effects of all drugs of abuse tested and to those of the dopamine receptor agonist apomorphine. Locomotor sensitization to repeated injections of cocaine was facilitated in ethanol-exposed animals. Ethanol-induced conditioned place preference was also facilitated in ethanol-exposed animals. Ethanol consumption and preference were increased after early life ethanol exposure and this was associated with decreased sensitivity to the sedative effects of ethanol. The altered behavioral responses to drugs of abuse were associated with decreased striatal dopamine transporter and hippocampal NMDAR binding. Our results outline an increased vulnerability to rewarding and stimulant effects of ethanol and psychostimulants and support the epidemiological and clinical data that suggested that early chronic exposure to ethanol may increase the propensity for later self-administration of ethanol or other substances.

Presentation

The Bioseb spatial place preference Test is an experimental chamber developed with the aim to optimise place preference and aversion studies in small laboratory animals, especially mice. The design of the box is fruit of a close collaboration with eminent Professor Dr. Rafael Maldonado and Dr. Olga Valverde from the Laboratory of Neuropharmacology in Barcelona (Spain).


Operating principle

The apparatus consists in a box with two equally sized compartments interconnected by a rectangular corridor. Originally, the compartments are differentiated by the motifs painted on the walls (dots or stripes) and the colour (different shade of grey tones, light or dark) and texture (smooth or rough) of the floor. The innovation brought by this box is the possibility to combine a new additional spatial dimension to allow the animal differentiate the different compartments in a more discriminative manner. Transparent walls are also used to minimize the time the animal spent in the corridor.



The introduction of these new discriminative elements allows:
• optimising the results obtained in the place preference and aversion paradigms (low variability in the response, reduced number of animals per group...)
• organizing the discriminative elements in a wide variety of configurations for studies evaluating spatial or contextual memory
• using the elements as discriminative cues associated with drug exposure in diverse other experimental designs.


The Bioseb spatial place preference box can be associated with the SMART video-tracking system for detection and analysis of animal position throughout the test.


Parameters Measured

• Parameters given by the associated video-tracking system
• Permance time in user-defined zone (SMART)
• Number of entries into user-defined zone (SMART)
• Distance travelled (SMART)
• And more... (SMART)


Key features

• Allows a multiple combination between the visual, tactile and spatial cues defining each compartment
• Optimize the differentiation between compartments
• Minimize initial place preference during pre-test phase
• Transparent walls to minimize time spent in the corridor
• Optimize subject detection using a video-tracking system


Supplied with

• Spatial Place Preference Box
• 2 reversible floors (one colored dark grey, the other light grey)
• 4 parallelepiped triangles (two colored in stripes, the other two in dots)
• 2 three sides pyramids (one colored in stripes, the other in dots)
• 2 sliding doors (one colored in stripes, the other in dots)


Options

• Smart Video Tracking System


Publications (Click on an article to show details and read the abstract)


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Reversible Floor's texture One side rough, one side smooth
Total Dimensions 440 (W) x 250 (D) x 250 (H) mm
Compartment Dimensions 200 (W) x 180 (D) x 250 (H) mm
Aisle Dimensions 200 (W) x 70 (D) x 250 (H) mm

Model:
LE895
Spatial place preference Test (Modif.)
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Accessories :
SMART
SMART Video Tracking System (Modif.)
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PPCWIN
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