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VON FREY FILAMENTS
(Model: Bio-VF-M)
A set of 20 monofilaments based on the Semmes Weinstein monofilament set - featuring retractable filaments to protect the filament and allow the investigator to carry a few around in a pocket

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  • NIH Bethesda, Etats-Unis
  • DUKE UNIVERSITY MEDICAL CENTER Durham, Etats-Unis
  • KB SCIENCE CORP Bellebue, Etats-unis
  • MICROBIA, INC Cambridge, Etats-unis
  • PRODUCT SAFETY LABS Dayton, Etats-unis
  • UNIVERSITY OF MICHIGAN Ann Arbor, Etats-unis
  • UNIVERSITY OF PENNSYLVANIA Philadelphia, Etats-unis
  • UNIVERSITY OF WASHINGTON Seatle, Etats-unis
  • WASHINGTON UNIVERSITY St Louis, Etats-unis
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! NEW RESEARCH WORK ! A recent publication by Danize Aparecida Rizzetti, Francisca Fernandez, Silvia Moreno et al in "Brain Research" highlights the merits of using Bioseb's Von Frey Filaments: EGG WHITE HYDROLYSATE PROMOTES NEUROPROTECTION FOR NEUROPATHIC DISORDERS INDUCED BY CHRONIC EXPOSURE TO LOW CONCENTRATIONS OF MERCURY

EGG WHITE HYDROLYSATE PROMOTES NEUROPROTECTION FOR NEUROPATHIC DISORDERS INDUCED BY CHRONIC EXPOSURE TO LOW CONCENTRATIONS OF MERCURY
Danize Aparecida Rizzetti, Francisca Fernandez, Silvia Moreno et al
Cardiovascular Physiology Laboratory, Universidade Federal do Pampa, BR 472, Km 592, Uruguaiana, Rio Grande do Sul, Brazil
Published in "Brain Research" (2016-06-24)


This study aims to investigate whether the egg white hydrolysate (EWH) acts on the neuropathic disorders associated with long-term Mercury (Hg) exposure in rats. 8- week-old male Wistar rats were treated for 60 days with: a) Control - saline solution (i.m.); b) Mercury - HgCl2 (1st dose 4.6 ?g/kg, subsequent doses 0.07 ?g/kg/day, i.m.); c) Hydrolysate - EWH (1 g/kg/day, gavage); d) Mercury and Hydrolysate. Mechanical allodynia was assessed using Von Frey Hairs test; heat hyperalgesia by the plantar test; catalepsy by a modification of the “ring test” and spontaneous locomotor activity by a photocell activity chambers. Analyses were performed at 0, 30 and 60 days of treatment. Brain and plasma MDA, plasma NPSH and TNF-? determination and skin immunohistochemistry were performed at 60 days. Hg induced a reduction in mechanical sensitivity threshold at 30 and 60 days and in thermal sensitivity threshold at 60 days. At the end of treatment catalepsy was developed, but there was not significant alteration in spontaneous locomotor activity. Hg also increased brain and plasma MDA, plasma NPSH and TNF- ? levels and the number of Merkel cell–neurite complex in the skin. EWH prevented the development of mechanical allodynia, thermal hyperalgesia and catalepsy induced by Hg and the increase in MDA concentration in brain and plasma and in the number of Merkel cell–neurite complex in the skin. In conclusion, EWH promotes neuroprotection against the toxic effects caused by Hg, demonstrating a beneficial therapeutic potential.
This set of 20 monofilaments is based on the Semmes Weinstein monofilament set, but now features retractable filaments to protect the filament and allow the investigator to carry a few around in a pocket.

The Semmes Weinstein set of monofilaments provide an approximately logarithmic scale of actual force, and a linear scale of perceived intensity. They have a long history of effective use in clinical settings, and can be used to diagnose pathologies of hyper- or hypo-aesthesia. Subsets within the set of 20 probes distinguish pathologies on different parts of the body (foot, hand, lip, cheek, etc.).

The operating principle remains the same: when the tip of a fiber of given length and diameter is pressed against the skin at right angles, the force of application increases as long as the researcher continues to advance the probe, until the fiber bends. After the fiber bends, continued advance creates more bend, but not more force of application. This principle makes it possible for the researcher using a hand held probe to apply a reproducible force, within a wide tolerance, to the skin surface.

Size 1,652,362,442,833,223,613,844,08 4,174,314,564,744,935,075,185,46 5,886,16,456,65
Force (g) 0,0080,020,040,070,160,40,61 1,42468101526 60100180300

Rodents exhibit a paw withdrawal reflex when the paw is unexpectedly touched. The Touch Test™ Sensory Evaluator can be used on the Plantar surfaces of the foot of a rat or mouse, and the animal will indicate sensation by pulling back its paw. Replacement filaments available.

Attention : Because of the physical properties of the material making up the filaments it's recommended to work at temperature between 18°C an 24°C and hygrometry between 60 and 80 %, for a better reliability of the results.

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Model:
Bio-VF-M
Von Frey Filaments (Modif.)
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