NEWS & EVENTS Tell a friend
Meet Bioseb at incoming Pain Events/Conferences

The International Association of Study of Pain (IASP) defines Pain as follows : "An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage."
Pain is therefore a neurological, physiological, psychological, global event presenting both a sensory and emotional dimension. It is difficult to quantify objectively, since it depends on the subjective perception of each individual.

Nevertheless, over 80% of the world population suffers from pain, and 30% of the world population suffers from chronic pain. When chronic, pain is not considered as a symptom anymore, but as an illness in its own right. Research aiming at appropriate pain treatments is consequently one of the major challenges of the scientific community.

Bioseb brings a unique expertise to this field : we offer reliable and objective solutions for quantifying pain levels in rodents within the framework of your pre-clinical study. As such, we will naturally be present for all the major events of the French and International Pain research community – and will introduce numerous instruments for pain measurement in inflammatory, nociceptive and dysfunctional models.

You will be able to meet our technical teams for live product demonstrations on following events :

The Challenge of Chronic Pain
1st-3rd of March, 2017
Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom

Meet Bioseb @ The Challenge of Chronic Pain, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom, 2017
Click here to get more information about this event


13eme Symposium National du Réseau de Recherche sur la Douleur
17th-18th of March, 2017
Campus Saint-Charles, Marseille, France

Meet Bioseb @ 13eme Symposium National du Réseau de Recherche sur la Douleur, Marseille, France, 2017
Click here to get more information about this event

Osteoarthritis: Dynamic Weight Bearing & Guinea pig
To date, there is no validated tool available for the evaluation of weight bearing and gait in Guinea pig. To address this issue, Bioseb and Artialis have initiated a collaboration to validate Dynamic Weight Bearing platform in Guinea pig model of spontaneous osteoarthritis.

WEIGHT BEARING

Weight bearing in rodents, also named "incapacitance" test, is well known in nociceptive and analgesia research works, and used for studying osteoarthritis (OA) among others disorders.

Traditional static type instruments have been used in the last years in rodents. In particular, it is well documented for some species such as rat and mouse.

However, static incapacitance instruments are highly dependent on the animal’s position inside a stressful restrainer. This makes these systems time-consuming and difficult to use, particularly when large number of rodents are considered.

To address this issue, Bioseb developed the Dynamic Weight Bearing (DWB), a test to assess spontaneous pain in freely moving rodents. This device is based on an instrumented-floor cage and in combination with a video acquisition system.

In its latest version, the Advanced Dynamic Weight Bearing, is a semi-automatic, operator-independent instrument.

The Advanced DWB system offers the possibility of conducting experiments without an operator. It thus reduces the stress on the animal and the need for habituation period. The analysis of 1 animal will take 1 to 2 minutes.

With exclusive features, the Advanced DWB opens the way to improved generation of instruments for drugs screening and optimization of preclinical models.

Dynamic Weight Bearing set up. The animal is place in a Plexiglas chamber where he can move freely. The chamber is doted of a video acquisition system and the floor is made of sensors.

SPONTANEOUS MODEL OF OA IN GUINEA PIG

The spontaneous model of OA in Dunkin Hartley Guinea pig presents a strong translational value for its similarities with human disease.

Artialis developed a solid expertise using this model to evaluate potential OA treatment (drug, medical device, or dietary supplement). Several parameters of analysis were validated, from gold-standard end-points as histology to differentiating information as biomarkers or biomechanics of articular cartilage.

A complete solution including animal housing facilities and trained experimenters is available at Artialis’ facilities in Novalis Science Park in collaboration with CER group. These facilities offer a high quality level to customers, in an environment meeting the highest certification criteria.

Screenshot of one of the first acquisitions with guinea pigs from the DWB interface
Screenshot of one of the first acquisitions with guinea pigs from the DWB interface. The camera allows to monitor animal moves. Each move is recorded by the sensors and translated into pixels on the screen. These records are further processed to analyze animal gait and motion.
THE VALIDATION STUDY

The study is held in the preclinical facilities of Artialis at the Novalis Science Park in collaboration with CER group.

A 3-month follow-up during the spontaneous development of OA will determine the relevance of using DWB in guinea pigs. It provides the opportunity for new adaptation and new development of the system to the Guinea Pig model. This is thus a true interaction between respective expertise of the parties that will allow the development of the application for the guinea pig and its validation. The results will be correlated to histological data to confirm the relevance of the measurements.

First acquisitions are well encouraging with excellent scoring abilities of the system. All data and study results will be published in an official scientific communication early 2017.

Bioseb: Annual Congress of the Society for Neuroendocrinolog

The University of Corsica and its president, Pr. Paul Marie ROMANI, partnered with the Society for Neuroendocrinology (Société de Neuroendocrinologie - SNE) and organized their 41st Annual Congress in Corte from the 5th until the 8th of October 2016, along with Quebec (5th common congress). Bioseb sponsored this event.

Neuroendocrinology is an important discipline at the interface between neuroscience and endocrinology (hormone studies). The 300 members of the Society for Endocrinology are not only French, but from the entire scientific francophone community of several countries: Belgium, Switzerland, Spain, Canada, Italy, Maghreb and Quebec. All these nationalities were represented in Corte. The aim of this annual colloquium was to allow young researchers to present original research works from their university or independent labs at the CNRS, INSERM, INRA, FRQ in Québec and Quebec or French universities.

The Bioseb Team is proud to have actively participated to this meeting, and to have been able to help value the work of young PhD by sponsoring prizes for two posters presenting high-quality work!


Katharina STOBBE :
"Effect of lipids nature on the establishment and maintenance of a Diet-Induced Obesity in mice"

Miled BOUROUROU :
"Omega-3 alpha linolenic acid as disease modifier in stroke: effect on functional recovery and inflammation”

Congratulations to both laureates! Bioseb’s Team was impressed by the quality of their work, and is proud to have been able to offer these prizes.

SFN Meeting 2016 in San Diego - Thank you!

We would like to thank all of you who came to visit us on the SFN Meeting 2016 in San Diego, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in San Diego.

We maintain a spirit of curiosity, innovation and close collaboration with the field researchers to design and develop new and improved solutions. It has been a pleasure exchanging viewpoints and experience with you regarding in-vivo testing in neuroscience during the SFN meeting in San Diego.

We are looking forward to seeing you at the next meeting!
SfN Meeting 2016 in San Diego

OUR LATEST DEVELOPMENTS
WILL BE PRESENTED IN SAN DIEGO ON BOOTH nº534

Bioseb is looking forward to meeting you at the SfN Meeting 2016 held in San Diego, Nov 12-16, 2016. It will be a great opportunity to discuss your latest research projects with us, as well as your current equipment needs! A whole range of neuroscience instruments will be presented and available for real demonstrations.

Our technical and sales teams will be very happy to introduce a variety of instruments focusing on neuroscience, including the latest developments of our R&D.

Looking forward to meeting you at the SfN Meeting 2016 in San Diego, on booth nº534!
IASP Meeting 2016 in Yokohama - Thank you!

Thanks to all our visitors
at the IASP Meeting 2016 in Yokohama!

We would like to thank all of you who came to visit us on the IASP Meeting 2016 in Yokohama, especially the Pain Lab team of the Departement of Pharmacology of Pain, Institute of Pharmacology of Cracow : Natalia Malek, Jakub Mlost, Magdalena Kostrzewa, Katarzyna Starowicz for their poster on Bioseb's KWB : "Kinetic Weight Bearing, a unique and innovation instrument for Osteoarthritis research". The poster had a great audience, thanks to Natalia and Katarzyna.

Click here for more info about the Painlab and their poster involving Bioseb's Kinetic Weight bearing!


It was a pleasure for us to exchange viewpoints and experience on in-vivo testing in neuroscience.

Last but not least, we would like to thanks our sales representatives from Physio-Tech and BIoresearch who supported our technical team during the meeting and facilitated our discussions with our Japanese customers.

We are looking forward to seeing you at the next meeting!
GDR Vertige Meeting, Marseille, Sept. 23-24

WE WILL BE PRESENT
AT THE GDR VERTIGE MEETING 2016 IN MARSEILLES

Bioseb is looking forward to meeting you at the GDR Vertige Meeting 2016 held in Marseille, September 23 - 24th. It will be a great opportunity to discuss your latest research projects with us, as well your current equipment needs!

Our technical and sales teams will be very happy to discuss the latest developments of our R&D.

Looking forward to meeting you at the GDR Vertige Meeting 2016 in Marseille!
Bioseb at the IASP Meeting 2016 in Yokohama, Japan

Bioseb is proud to renew its partnership with the International Association for the Study of Pain (IASP) this year, from the 26th to 30th of September. Bioseb's latest innovations will be presented at the 16th World Congress of Pain in Yokohama, and ready for demonstration at booth nº662.

As a special service to our Japanese customers, sales representatives from the Japanese companies, Physio-Tech and Bioresearch, will be supporting our technical team for the duration of the meeting, and facilitate open discussions. We are all excited to meet you and discuss your research projects.

Looking forward to meeting you at the 16th World Congress on Pain in Yokohama, Japan, on booth nº662!

Probecare Scientific's visit at Bioseb's Headquarter

THANK YOU TO PROBECARE SCIENTIFIC, Inc.
FOR THEIR VISIT TO OUR HEADQUARTERS


Beginning of May, Bioseb was honoured by the visit of the estimated Chinese company Probecare Scientific, Inc. at Bioseb's Headquarters.

The visit has been the occasion of high-quality exchanges of information regarding Bioseb's full range of products. Among the highlights, the Probecare team has been trained to the Kinetic Weight Bearing, an innovative instrument from Bioseb that allows the measure of rodents gait parameters combined with dynamical force application during a walking sequence.

We wish to Probecare a lot of success promoting Bioseb's solutions for Pain and Activity monitoring in China, through their HQ in Wuhan and several sales offices all over China.

Many thanks to Probecare for the fruitful visit and hope for a win-win partnership in the future !

FENS Meeting 2016 in Copenhagen - Thank you!

Thanks to all our visitors
at the FENS Meeting 2016 in Copenhagen!

We would like to thank all of you who came to visit us on the FENS Meeting 2016 in Copenhagen, especially Mrs Aurélie Amadio et M. Daniel Voisin, from the Magendie Neurocentre in Bordeaux, France, for presenting the results of their research work based on our DWB (Dynamic Weight Bearing) for the study of formaline: "Evaluation Of Dynamic Weight Bearing For Measuring Paw Formalin-induced Pain In Rats"

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing in neuroscience.

We are looking forward to seeing you at the next meeting!
FENS Meeting 2016 in Copenhagen

OUR LATEST DEVELOPMENTS
WILL BE PRESENTED IN COPENHAGEN ON BOOTH nº129

Bioseb is looking forward to meeting you at the FENS Meeting 2016 held in Copenhagen, July 2nd - 6th. It will be a great opportunity to discuss your latest research projects with us, as well your current equipment needs! A whole range of neuroscience instruments will be presented and available for real demonstrations.

Our technical and sales teams will be very happy to introduce a variety of instruments focusing on neuroscience, including the latest developments of our R&D.

Looking forward to meeting you at the FENS Meeting 2016 in Copenhagen, on booth nº129!
SdN Meeting 2016 in Tours - Thank you!

We would like to thank all of you who came to visit us on the SdN Meeting 2016 in Tours, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in Tours.

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing in neuroscience.

We especially would like to thank Mr. Yves Tillet and his team for organizing the meeting and welcoming us in such a warm manner.

We are looking forward to seeing you at the next meeting!
OARSI Meeting 2016 in Amsterdam - Thank you!

We would like to thank all of you who came to visit us on the OARSI Meeting 2016 in Amsterdam, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in Amsterdam.

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing in neuroscience.

We are looking forward to seeing you at the next meeting!
Upcoming meetings in 2016
Bioseb is proud to be present at all major upcoming scientific meetings in 2016, and looking forward to meeting you there!

Our sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2015 and 2016. Please visit Bioseb's booth on following scientific meetings:

SdN Tours (Société des Neurosciences) - May 24/25 - Tours - France
FENS Copenhagen (Fed. or Europ. Neuroscience Societies) - July 2/6 - Copenhagen, Danemark
IASP Yokohama (International Association for the Study of Pain) - Sept. 26/30
SFN San Diego (Society for Neuroscience) - Nov. 12/16 - San Diego - USA


Our latest Neuroscience In Vivo Testing instruments will be presented there and ready to use. Please ask for a demonstration!
OARSI Meeting 2016 in Amsterdam

OUR LATEST DEVELOPMENTS
WILL BE PRESENTED IN AMSTERDAM ON BOOTH nº13

Bioseb is looking forward to meeting you at the OARSI Meeting 2016 held in Amsterdam, from March 31st until April 1st, 2016. It will be a great opportunity to discuss your latest research projects with us, as well your current equipment needs! A whole range of pain-related instruments will be presented and available for real demonstrations.

Our technical and sales teams will be very happy to introduce a variety of instruments focusing on osteoarthritis, including the latest developments of our R&D.

Looking forward to meeting you at the OARSI Meeting 2016 in Amsterdam, on booth nº13!
Allodynia & Cold/Hot Plate test: Transpharmation's research

Bioseb is happy and proud to present the latest research from Transpharmation and The Royal Veterinary College, London, UK, by Ran Magnusdottir, Amy Fisher and Neil Upton, who used Bioseb's Cold/Hot Plate test for their research:

Reversal of cold and mechanical allodynia with pregabalin
in a rodent model of chemotherapy induced peripheral neuropathy

Background: Chemotherapy- induced peripheral neuropathy (CIPN) is a dose limiting side effect in the use of the platinum-based antineoplastic drug oxaliplatin. Currently there is no treatment available to reverse the neurotoxicity which presents as pain, sensory loss and cold allodynia in up to 80% of patients.

Bioseb's Cold Hot Plate Test - Transpharmation's Study - Alloynia curves
Click to see
Transpharmation's curves
Results: CIPN was induced in 10 male C57BL/6 mice (6 weeks) with a single intraperitoneal injection of oxaliplatin (15mg/kg i.p.). Signs of cold and mechanical allodynia were assessed by Cold/Hot plate (Bioseb, France) at 20°C and hand-held von Frey (vF) hairs from baseline to 20 days after injection. Mechanical and cold allodynia were established 3 days post Oxaliplatin injection and remained stable for 14 days. At day 15, pregabalin (3mg/kg p.o.) reversed mechanical allodynia to baseline scores at 2 hours (H) post dosing, and cold allodynia at 1H and 2H post dosing. Following a 2 day wash out where scores returned to neuropathic baseline, pregabalin (10 mg/kg p.o.) returned scores for mechanical and cold allodynia to baseline scores at both 1H and 2H. Cold testing was performed either immediately after vF or alone with the same results, showing no iatrogenic effects of vF on cold sensitivity. Correlation analysis of the responses to cold and mechanical stimuli showed no clear trend, indicating that oxaliplatin induced peripheral neuropathy affects the two modalities in different ways.

Conclusions: Oxaliplatin induced peripheral neuropathy as measured by cold and mechanical allodynia is reversible by a single dose of pregabalin.

For more information, please contact:
Amy S. Fisher, PhD - Principal Scientist, Transpharmation Ltd
amy.fisher@transpharmation.co.uk - Tel: +44 (0)17 0764 2162
Web: www.transpharmation.co.uk

Bioseb's Hot/Cold plate is becoming a must when studying rodent's Cold hyperalgesia/allodynia. Focussing on Oxaliplatin-induced Thermal Hypersensitivity, it has been proven to be a valid Behavioural test in numerous papers, such as :

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. (2011)
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors.
J. Descoeur, V. Pereira, A. Pizzoccaro, A. Francois, B. Ling et al. (Team of Dr Bourinet)
Institut de Génomique Fonctionnelle, CNRS, UMR-5203, Département de Physiologie, Montpellier, France.
Published in "EMBO Molecular Medicine" (2011-05-24)


Cold hypersensitivity is the hallmark of oxaliplatin-induced neuropathy, which develops in nearly all patients under this chemotherapy. To date, pain management strategies have failed to alleviate these symptoms, hence development of adapted analgesics is needed. Here, we report that oxaliplatin exaggerates cold perception in mice as well as in patients. These symptoms are mediated by primary afferent sensory neurons expressing the thermoreceptor TRPM8. Mechanistically, oxaliplatin promotes over-excitability by drastically lowering the expression of distinct potassium channels (TREK1, TRAAK) and by increasing the expression of pro-excitatory channels such as the hyperpolarization-activated channels (HCNs). These findings are corroborated by the analysis of TREK1-TRAAK null mice and use of the specific HCN inhibitor ivabradine, which abolishes the oxaliplatin-induced cold hypersensibility. These results suggest that oxaliplatin exacerbates cold perception by modulating the transcription of distinct ionic conductances that together shape sensory neuron responses to cold. The translational and clinical implication of these findings would be that ivabradine may represent a tailored treatment for oxaliplatin-induced neuropathy.

Anticancer Activity of Methyl-substituted Oxaliplatin Analog. (2012)
Anticancer Activity of Methyl-substituted Oxaliplatin Analog.
U. Jungwirth, D. Xanthos, J. Gojo, A. Bytzek, W. Korner et al.
Medical University of Vienna, Institute of Cancer Research, Vienna, Austria.
Published in "Molecular pharmacology" (2012-05-30)


Oxaliplatin is successfully used in systemic cancer therapy. However, resistance development and severe adverse effects are limiting factors for curative cancer treatment with oxaliplatin. The purpose of this study was to comparatively investigate in vitro and in vivo anticancer properties as well as the adverse effects of two methyl-substituted enantiomerically pure oxaliplatin analogs [[(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine] oxalatoplatinum(II) (KP1537), and [(1R,2R,4S)-4-methyl-1,2-cyclohexanediamine]oxalatoplatinum(II) (KP1691)] and to evaluate the impact of stereoisomerism. Although the novel oxaliplatin analogs demonstrated in multiple aspects activities comparable with those of the parental compound, several key differences were discovered. The analogs were characterized by reduced vulnerability to resistance mechanisms such as p53 mutations, reduced dependence on immunogenic cell death induction, and distinctly attenuated adverse effects including weight loss and cold hyperalgesia. Stereoisomerism of the substituted methyl group had a complex and in some aspects even contradictory impact on drug accumulation and anticancer activity both in vitro and in vivo. To summarize, methyl-substituted oxaliplatin analogs harbor improved therapeutic characteristics including significantly reduced adverse effects. Hence, they might be promising metal-based anticancer drug candidates for further (pre)clinical evaluation.

P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach (2013)
P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach
F. Massicot, G. Hache, L. David, D. Chen, C. Leuxe et al.
Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Paris, France
Published in "PLOS One" (2013-06-27)


Limited information is available regarding the cellular mechanisms of oxaliplatin-induced painful neuropathy during exposure of patients to this drug. We therefore determined oxidative stress in cultured cells and evaluated its occurrence in C57BL/6 mice. Using both cultured neuroblastoma (SH-SY5Y) and macrophage (RAW 264.7) cell lines and also brain tissues of oxaliplatin-treated mice, we investigated whether oxaliplatin (OXA) induces oxidative stress and apoptosis. Cultured cells were treated with 2–200 µM OXA for 24 h. The effects of pharmacological inhibitors of oxidative stress or inflammation (N-acetyl cysteine, ibuprofen, acetaminophen) were also tested. Inhibitors were added 30 min before OXA treatment and then in combination with OXA for 24 h. In SH-SY5Y cells, OXA caused a significant dose-dependent decrease in viability, a large increase in ROS and NO production, lipid peroxidation and mitochondrial impairment as assessed by a drop in mitochondrial membrane potential, which are deleterious for the cell. An increase in levels of negatively charged phospholipids such as cardiolipin but also phosphatidylserine and phosphatidylinositol, was also observed. Additionally, OXA caused concentration-dependent P2X7 receptor activation, increased chromatin condensation and caspase-3 activation associated with TNF-α and IL-6 release. The majority of these toxic effects were equally observed in Raw 264.7 which also presented high levels of PGE2. Pretreatment of SH-SY5Y cells with pharmacological inhibitors significantly reduced or blocked all the neurotoxic OXA effects. In OXA-treated mice (28 mg/kg cumulated dose) significant cold hyperalgesia and oxidative stress in the tested brain areas were shown. Our study suggests that targeting P2X7 receptor activation and mitochondrial impairment might be a potential therapeutic strategy against OXA-induced neuropathic pain.

The Nav1. 9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia (2015)
The Nav1. 9 Channel Is a Key Determinant of Cold Pain Sensation and Cold Allodynia
Lolignier S, Bonnet C, Gaudioso C, Noël J, Ruel J et al.
Pharmacologie Fondamentale et Clinique de la Douleur, Clermont Université, Université d'Auvergne, Clermont-Ferrand, France;
Published in "Cell Rep. " (2015-05-19)


Cold-triggered pain is essential to avoid prolonged exposure to harmfully low temperatures. However, the molecular basis of noxious cold sensing in mammals is still not completely understood. Here, we show that the voltage-gated Nav1.9 sodium channel is important for the perception of pain in response to noxious cold. Nav1.9 activity is upregulated in a subpopulation of damage-sensing sensory neurons responding to cooling, which allows the channel to amplify subthreshold depolarizations generated by the activation of cold transducers. Consequently, cold-triggered firing is impaired in Nav1.9(-/-) neurons, and Nav1.9 null mice and knockdown rats show increased cold pain thresholds. Disrupting Nav1.9 expression in rodents also alleviates cold pain hypersensitivity induced by the antineoplastic agent oxaliplatin. We conclude that Nav1.9 acts as a subthreshold amplifier in cold-sensitive nociceptive neurons and is required for the perception of cold pain under normal and pathological conditions.

A Polyamine-Deficient Diet Prevents Oxaliplatin-Induced Acute Cold and Mechanical Hypersensitivity in Rats (2013)
A Polyamine-Deficient Diet Prevents Oxaliplatin-Induced Acute Cold and Mechanical Hypersensitivity in Rats
J.Ferrier, M.Bayet-Robert, B.Pereira, L.Daulhac
FACULTE DE MEDECINE, CLERMONT FERRAND, FRANCE
Published in "PLOS ONE" (2013-11-30)


Background
Oxaliplatin is an anticancer drug used for the treatment of advanced colorectal cancer, but it can also cause painful peripheral neuropathies. The pathophysiology of these neuropathies has not been yet fully elucidated, but may involve spinal N-methyl-D-aspartate (NMDA) receptors, particularly the NR2B subunit. As polyamines are positive modulators of NMDA-NR2B receptors and mainly originate from dietary intake, the modulation of polyamines intake could represent an interesting way to prevent/modulate neuropathic pain symptoms by opposing glutamate neurotransmission.
Methods
The effect of a polyamine deficient diet was investigated in an animal model of oxaliplatin-induced acute pain hypersensitivity using behavioral tests (mechanical and cold hypersensitivity). The involvement of spinal glutamate neurotransmission was monitored by using a proton nuclear magnetic resonance spectroscopy based metabolomic approach and by assessing the expression and phosphorylation of the NR2B subunit of the NMDA receptor.
Results
A 7-day polyamine deficient diet totally prevented oxaliplatin-induced acute cold hypersensitivity and mechanical allodynia. Oxaliplatin-induced pain hypersensitivity was not associated with an increase in NR2B subunit expression or phosphorylation, but with an increase of glutamate level in the spinal dorsal horn which was completely prevented by a polyamine deficient diet. As a validation that the oxaliplatin-induced hypersensitivity could be due to an increased activity of the spinal glutamate system, an intrathecal administration of the specific NR2B antagonist, ifenprodil, totally reversed oxaliplatin-induced mechanical and cold hypersensitivity.
Conclusion
A polyamine deficient diet could represent a promising and valuable nutritional therapy to prevent oxaliplatin-induced acute pain hypersensitivity.

Assessment of thermal sensitivity in rats using the thermal place preference test: description and application in the study of oxaliplatin-induced acute thermal hypersensitivity and inflammatory pain models. (2014)
Assessment of thermal sensitivity in rats using the thermal place preference test: description and application in the study of oxaliplatin-induced acute thermal hypersensitivity and inflammatory pain models.
Balayssac D, Ling B, Ferrier J, Pereira B, Eschalier A, Authier N.
Faculties of Medicine and Pharmacy, Clermont Université, France
Published in "Behav Pharmacol." (2014-04-25)


Thermal sensitivity is an essential characteristic of some painful states, including oxaliplatin-induced neuropathy. The thermal place preference test (TPPT) was designed to finely assess thermal sensitivity in rodents. The TPPT monitors the time spent by unrestrained rodents on a test plate at fixed temperatures (5-50°C) compared with an adjacent reference plate at a neutral temperature (25°C). Here, we report the results of a study designed (i) to validate the optimal methodological parameters for measuring thermal sensitivity in rats, (ii) to assess the thermal sensitivity of healthy rats and animal models of pain and (iii) to explore the pharmacological effects of analgesic drugs. The most reproducible conditions occurred when the TPPT was performed in the morning and in the dark for 3 min with the reference plate set to 25°C. The temperature preferences of healthy rats were more than 17°C and less than 40°C. When compared with control animals, oxaliplatin-treated rats showed thermal hypersensitivity at 12, 20 and 35°C, and carrageenan-treated rats showed thermal hypersensitivity at 15 and 45°C. Duloxetine (2.5 mg/kg, intraperitoneal) reversed oxaliplatin-induced cold hypersensitivity (20°C) and morphine (1 mg/kg, intravenous) reversed carrageenan-induced heat hypersensitivity (45°C). We conclude that the TPPT enables a fine-grained assessment of thermal sensitivity that is relevant to the pathophysiological exploration of animal pain models and to the pharmacological assessment of analgesic drugs.



All the Bioseb team wishes you a Happy New year 2016 !
Not only our little mice are enjoying walking on Tchouri under the eyes of Philae, but also your research projects are going ahead step-by-step and we, at Bioseb, wish to be at your side for each bigger step, in order to help Scientific Research in its ambitious pathway.

All the Bioseb team wishes you a Happy New year 2016 !

SFN Meeting 2015 in Chicago - Thank you!

We would like to thank all of you who came to visit us on the SFN Meeting 2015 in Chicago, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in Chicago.

We've been present at each SFN meeting since 2008 - but you've been more and more numerous each year to drop by our stand to discuss your applications and our solutions! Thanks to all of you for your trust, your interest, and your visit.

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing in pain studies.

We particularly enjoyed the discussions regarding our operator-independent assays for objective data collection. Thermal Preference Test, Forced Swimming Test, Tail Suspension Test, Novel Object Recognition and many other instruments from Bioseb provide direct, reliable & consistent results independently of the operator.

You will of course always lead your investigation, but instrumentation is Bioseb's expertise. We are committed to give you accurate, consistent and validated data, only in IS units.

Bioseb is already looking forward to meeting you
at the next meetings!



SfN Meeting 2015 in Chicago

OUR LATEST DEVELOPMENTS
WILL BE PRESENTED IN CHICAGO ON BOOTH nº2055

Bioseb is looking forward to meeting you at the SfN Meeting 2015 held in Chicago, Oct 17-21, 2015. It will be a great opportunity to discuss your latest research projects with us, as well your current equipment needs! A whole range of neuroscience instruments will be presented and available for real demonstrations.

Our technical and sales teams will be very happy to introduce a variety of instruments focusing on neuroscience, including the latest developments of our R&D.

Looking forward to meeting you at the SfN Meeting 2015 in Chicago, on booth nº2055!
KWB: Thank You to the European Federation Krakow Pain School

The Pain Lab of the Institute of Pharmacology of Kracow, Poland, is as excited as we are about their upcoming research work using our ground-breaking Kinetic Weight Bearing instrument! Let them tell us more about it:

Pain Lab is one of the very few research laboratories possessing KWB. The KWB has been validated by Marseille (CNRS UMR 7286, Faculty of Medecine, Université de la Mediterranée, Marseille) and Florida’s labs (The Miami project to Cure Paralysis) that had the equipment on rent. In the coming month, Bioseb is going to install a KWB in dual-version (Rat+Mice) at Salk Institute for Biological Studies, La Jolla, California.

We do hope we’ll be able to gain much exciting kinetic data. KWB provides information on applied weight as well as the speed and acceleration of each paw as the animal moves toward the end point of the runaway platform. This additional data provides facts on coordination and gait comparison paw-to-paw and step-to-step.

Well, it looks like we are ready to perform the first development curve for OA animals.


Click here to read the whole story on their blog!...

The Bioseb team is certainly looking forward to the innovative research work that the PainLab of Cracaw will be able to perform using our Kinetic Weight Bearing instrument. We work very closely with laboratories all around the world to drive our Research & Development towards new developments that match the latest application needs - and our Kinetic Weight Bearing aims at providing a new tool for your research on analgesia, nociception and neuroscience, especially suited for work on Parkinson’s disease, Alzheimer’s disease, arthritis, brain or spinal cord injury.

Click here to know more about our Kinetic Weight Bearing Instrument
European Federation Krakow Pain School: a great meeting!

Bioseb would like to thank the European Federation Krakow Pain School for the professional, and always friendly, organisation of the first European Federation Krakow Pain School Meeting.

The Translation Pain Event : from Lab to Clinic, which happened from the 5th to th 9th of July in Krakow, Poland, gathered the highest Specialists on Pain and selected high-profile Pain students for lectures and practical workshops. One of the workshops involved the Dynamic Weight Bearing, a Bioseb innovation, which has become a gold-standard equipment for Pain evaluation!


This event was the occasion for us to demonstrate Bioseb's practical expertise in Pain research specifically on rodent, with the presentation of a wide range of instruments for basic and advanced research.

The European Federation Krakow Pain School was not only appreciated for the quality of the lectures and participants' discussions: Anne did also really enjoy the warm evening atmosphere of Krakow during the guided tour.

We wish the European Federation Krakow Pain School all the best, with the hope that this event will be the first of a long and successful story!


ISBS 2015 in Miami - 22-24 June 2015

Bioseb is happy and proud to be present at 5th International Regional "Stress and Behavior" Neuroscience and Biopsychiatry Conference (ISBS) in Miami, Florida, USA, from June 22nd until June 24th.

Our CEO scheduled an intervention in front of all delegates in order to present the latest innovations in stress and behavior measuring instruments, and especially our brand new 3D Open Field technology.

A big Thank You to all participants for the high quality exchanges on your research needs - Bioseb's innovation model is focusing on your applications, and meeting your teams during congresses like the ISBS is essential to develop the instruments you need.

Click here to see the detailed description of our OF3C - Automated 3D Open Field System

SFN Meeting 2014 in Washington, DC - Thank you!

We would like to thank all of you who came to visit us on the SFN Meeting 2014 in Washington, DC, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in Washington, DC.

We've been present at each SFN meeting since 2008 - but this year, thanks to you, we broke the record of visits! Thanks to all of you for your trust, your interest, and your visit.

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing in pain studies.

Bioseb is already looking forward to meeting you
at the next meetings!


Click here to see a larger version of Bioseb's stand in Washington, DC

IASP Meeting 2014 in Buenos Aires - Thank you!

We would like to thank all of you who came to visit us on the IASP Meeting 2014 in Buenos Aires, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in Buenos Aires.

Among them, our special thank goes to all research teams from Brazil, Chile, Argentina and Uruguay for their visit and their precious collaboration with Bioseb!

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing in pain studies.

Bioseb is already looking forward to meeting you
at the next meetings!


Click here to see a larger version of Bioseb's stand in Buenos Aires

IASP Meeting 2014 in Buenos Aires

OUR LATEST DEVELOPMENTS
WILL BE PRESENTED IN BUENOS AIRES, BOOTH nº425

Bioseb is looking forward to meeting you at the IASP Meeting 2014 held in San Diego, Oct 6-10, 2014. It will be a great opportunity to communicate with us about your research projects and your equipment needs. A whole range of neuroscience instruments will be presented and available for real demonstrations.

Our technical and sales teams will be very happy to introduce a variety of instruments focusing on neuroscience, including the latest developments of our R&D:

Activity wheels: new design for both rats and mice, with LCD display
Electronic Von Frey: our new version is the next standard for reflex testing on freely moving rodents.
2 Temperatures Choice Test: Operator-independent and highly accurate thanks to powerful new software!

FENS Meeting 2014 in Milan - Thank you!

We would like to thank all of you who came to visit us on the FENS Meeting 2014 in Milan, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in Milan.

Among them, our special thank goes to all research teams from Poland, Hungary, Czech Republic and Switzerland for their visit and their precious collaboration with Bioseb!

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing in neuroscience.

Bioseb is already looking forward to meeting you
at the next meetings!


Click here to see a larger version of Bioseb's stand in Milan

APS Meeting 2014 in Tampa - Thank you!

We would like to thank all of you who came to visit us on the American Pain Society (APS) Meeting 2014 in Tampa, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in Tampa.

Among them, our special thank goes to Dr. Durga Mohapatra, from the University of Iowa, and to Dr. Robert W. Gereau IV, from the Washington University Pain Center, for their precious collaboration with Bioseb!

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing, nociception and analgesia with you.

Bioseb is already looking forward to meeting you
at the next meetings!


Click here to see a larger version of Bioseb's stand in Tampa

Upcoming meetings in 2014
Bioseb is proud to be present at all major upcoming scientific meetings in 2014, and looking forward to meeting you there!

Our sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2013 and 2014. Please visit Bioseb's booth on following scientific meetings:

APS Tampa - April 30–May 3, 2014 - American Pain Society - USA
FENS Milan - July 5-9, 2014 - MiCo - Milano Congressi - Italy
IASP Buenos Aires - October 6 – 11, 2014 – Buenos Aires - Argentina
SFN Washington - Nov. 15-19 2014 - Washington, DC - USA


Our latest Neuroscience In Vivo Testing instruments will be presented there and ready to use. Please ask for a demonstration!
Bioseb Catalog 2014

The Bioseb catalog 2014 is available for download in PDF format on Bioseb.com! An extended range of exclusive and innovative in-vivo research instruments from our R&D is at your disposal for all your research needs, focusing on the neuroscience fields of behavior evaluation, analgesia measurement, anxiety studies, loco motor activities, and much more!

The PDF catalog can be easily and quickly downloaded as follows:

1. Click here to access the download page.
2. If needed, register on bioseb.com using the form.
3. Enter your e-mail address , and start downloading!

SfN Meeting 2013 in San Diego - Thank you!
We would like to thank all of you who came to visit us on the Society for Neuroscience (SfN) Meeting 2013 in San Diego, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in San Diego.

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing with you.

Bioseb is already looking forward to meeting you
at the next meetings!


Click here to see a larger version of Bioseb's stand in San Diego
Society For Neuroscience: Meeting 2013 in San Diego

OUR LATEST DEVELOPMENTS
WILL BE PRESENTED IN SAN DIEGO, BOOTH nº334

Bioseb is looking forward to meeting you at the Society for Neuroscience Meeting 2013 held in San Diego, Nov 9-13, 2013. It will be a great opportunity to communicate with us about your research projects and your equipment needs. A whole range of neuroscience instruments will be presented and available for real demonstrations.

Our technical and sales teams will be very happy to introduce a variety of instruments focusing on neuroscience, including the latest developments of our R&D:

FST X’PERT: Forced Swimming Test - Automatic Version 3, extension for rats
KWB - KINETIC WEIGHT BEARING: Instrumented walking corridor
Brand new JUMP TEST: Cold/Hot Dynamic Plate Test

Canadian Neuroscience Meeting 2013 - Thank you!
We would like to thank all of you who came to visit us on the Canadian Neuroscience Meeting 2013 in Toronto, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in Toronto.

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing with you.

Bioseb is already looking forward to meeting you at the next meetings in 2013!

Canadian Neuroscience: Meeting 2013 in Toronto

OUR LATEST DEVELOPMENTS
WILL BE PRESENTED IN TORONTO, BOOTH nº17!

Bioseb is looking forward to meeting you at the Canadian Association of Neuroscience Meeting 2013 held in Toronto, May 21-24, 2013. It will be a great opportunity to communicate with us about your research projects and your equipment needs. A whole range of neuroscience instruments will be presented and available for real demonstrations.

Our technical and sales teams will be very happy to introduce a variety of instruments focusing on neuroscience, including the latest developments of our R&D:

FST X’PERT: Forced Swimming Test - Automatic Version 3, extension for rats
KWB - KINETIC WEIGHT BEARING: Instrumented walking corridor
Brand new JUMP TEST: Cold/Hot Dynamic Plate Test

Bioseb Pain Scholarship
BIOSEB calls for innovative project proposals, which will be funded by a new scholarship for applied research in pre-clinical neuroscience. The aim of this scholarship is to support doctoral students or recent PhD graduates in obtaining a new international experience by doing a laboratory internship abroad for a minimum of 6 months.



In line with the objectives of our founder Jacques Desevré, BIOSEB wishes to increase the mobility of young French and/or European researchers while supporting research progress in life science and promoting intercultural and interdisciplinary exchanges.

For the 2013-2014 edition, Canada is the hosting country, and the total scholarship is 12000 € / 16000 $ CAN

WARNING: THE APPLICATION DEADLINE IS JUNE 30TH 2013!

Click here to read a detailed description
of Bioseb Pain Scholarship
.
SFN 2012 - New Orleans - Thank you!
We would like to thank all of you who came to visit us on the Society for Neuroscience (SFN) Meeting 2012 in New Orleans, especially the numerous researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in New Orleans.

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing with you.

Bioseb is already looking forward to meeting you at the next meetings in 2013!



Click here to enlarge the picture of our stand
Society for Neuroscience 2011 - Meet Bioseb in New Orleans!
The Bioseb and EBI team will present our latest developments in neuroscience in-vivo instruments at the Society for Neuroscience meeting 2012 in New Orleans, USA, the premier venue for neuroscientists from around the world to debut cutting-edge research on the brain and nervous system.


Our technical and sales team will be very pleased to demonstrate the whole range of exclusive pain-measurement instruments developed in 2012 - please drop by for a demonstration on booth nº541!

IASP 2012 - Milan - Thank you!
We would like to thank all of you who came to visit us on the International Association for the Study of Pain (IASP) Meeting 2012 in Milan, especially following researchers who used Bioseb's instruments in their recent studies and published their research results on the posters presented in Milan:

Isabelle Decosterd for her work with our Activmeter :

Study of the mice motor activity in pain conditions, by Isabelle Decosterd, Guylene Kirschmann et al., Department of Anesthesiology and DBCM, Centre Hospitalier Universitaire Vaudois and Lausanne University, Switzerland

Dimitris Xanthos for his work with our Thermal Place Preference Test:

Characterization of rodent behavioral nociceptive tests to assess the motivational-affective pain component, by Dimitris Xanthos et al., Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Austria

You were numerous to take the opportunity for discovering the latest innovations from Bioseb, like our Kinetic Weight Bearing Apparatus, our Automatic Dynamic Weight Bearing Test, our Small Animal Algometer (SMALGO) or our Thermal Place Preference Test.

It was a pleasure for us to exchange viewpoints and experience on in-vivo testing with you.

Bioseb is already looking forward to meeting you at the
Society For Neuroscience (SFN) meeting 2012 in New Orleans in October!




Click here to enlarge the picture of our stand
Bioseb's Instruments: New Scientific Posters at IASP 2012
Bioseb team presents its respectful thanks to following research teams who used our In-Vivo research instruments during their recent studies, and mentioned our systems in numerous posters. These posters will be presented on the IASP 2012 in Milan, and you'll be able to meet the scientists during the various sessions!

• [PW 209] : Altered glutamate homeostasis in descending circuitry correlates with the emergence of pain chronicity, by Wei Guo et al., Neural and Pain Sciences, University of Maryland School of Dentistry, USA - Instrument: Electronic Von Frey

• [PF 273] : Study of the mice motor activity in pain conditions, by Isabelle Decosterd, Guylene Kirschmann et al., Department of Anesthesiology and DBCM>, Centre Hospitalier Universitaire Vaudois and Lausanne University, Switzerland - Instrument: Activmeter

• [PT 324] : The two-pore domain potassium channel trek2 is involved in mechanical nociception and thermal perception, by Vanessa Pereira et al., Laboratoire de Pharmacologie Clinique et Fondamentale de la Douleur, Inserm U1107, France - Instruments: Von Frey filaments, Cold/Hot Plate Test, Thermal Place Preference Test

• [PF 274] : Non-evoked pain tests in neuropathic rats, by Camille Le Cudennec et al., Pain & Inflammation, PORSOLT SAS, France - Instruments: Electronic Von Frey, Activmeter, Rotarod

• [PF 204] : Spinal expression of reactive glial markers in two different chronic pain models: bone cancer and neuropathy, by Vincent R. R. Ducourneau et al., Magendie Neurocenter INSERM U862, Bordeaux University, France - Instruments: Von Frey filaments, Dynamic Weight Bearing, Cold/Hot Plate Test

• [PF 209] : Effect of d-serine upon pain symptoms after functional inactivation of spinal cord astrocytes in a neuropathic chronic pain model, by Yan Alfred Lefèvre et al., Neurocentre Magendie INSERM, Bordeaux University, France - Instruments: Von Frey filaments, Dynamic Weight Bearing

• [PF 327] : Adding a dopaminergic action to antidepressants in the treatment of neuropathic pain: potential therapeutic utility of triple reuptake inhibitors (tri), by Guillaume Hache et al., Faculté de Pharmacie - Tour D1/2e, EA3544 "Neuropharmacology", France - Instruments: Von Frey filaments, Cold/Hot Plate Test, Thermal Place Preference Test, Elevated-Plus-Maze, Tail Suspension Test

• [PF 305] : Modulation of dynorphin system activity under neuropathic pain in rats, by Ewelina Rojewska et al., Department of Pain Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Poland - Instrument: Dynamic Weight Bearing

• [PF 304] : Burrowing as a non-reflex behavioral readout for analgesic action in a rat model of knee joint arthritis, by Kris Rutten et al., Pharmacology Pain, Grünenthal, Germany - Instrument: Static Weight Bearing

• [PW 286] : Pain relief devoid of opioid side effects following central action of a new neurotensin analog, by Pascal Tétreault et al., Physiology and Biophysic, Université de Sherbrooke, Canada - Instruments: Cold/Hot Plate Test, Dynamic Weight Bearing

• [PT 264] : Characterization of rodent behavioral nociceptive tests to assess the motivational-affective pain component, by Dimitris Xanthos et al., Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Austria - Instruments: Cold/Hot Plate Test, Thermal Place Preference Test

• [PH 351] : Gender difference in cold sensitivity: the role of testosterone, by Jerome Busserolles, Inserm, France - Instrument: Cold/Hot Plate Test

• [PF 253] : Vincristine treatment induces mechanical hyperresponsiveness in rat aδ-fibers, by M. Rocío Girón Moreno et al., Farmacología y Nutrición, Universidad Rey Juan Carlos, Spain - Instruments: Von Frey filaments, Rodent pincher, Cold/Hot Plate Test
Upcoming meetings
Bioseb is proud to be present at all major upcoming scientific meetings, and looking forward to meeting you there!

Our sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2012. Please visit Bioseb's booth on following scientific meetings:

FENS Barcelona - July 14-18, 2012 - Centre Convencions Internacional Barcelona (CCIB) - Spain
IASP Milan - August 27-31, 2012 - Milano Convention Centre - Italy
SFN New Orleans - October 13-17 - Ernest N. Morial Convention Center - USA

Our last Neuroscience In Vivo Testing instruments will be presented there and ready to use. Please ask for a demonstration!
New "Quick Request" function on Bioseb.com: fast and simple
What is the new “Quick Request” function on Bioseb.com ?

The “Quick Request” function, available from each instrument page on Bioseb.com, allows you to quickly contact the Bioseb team in order to obtain more information about a product. All you need to do is to click on the “Quick Request” button, type in your e-mail address and select the type of information you would like to receive. Our team will then contact you by e-mail as soon as possible with the requested information. This new functionality does not require any registration, and your e-mail address won’t be used for any e-mailing or commercial purpose other than sending you the requested information.

A fast and simple way to get in touch and receive additional information on our instruments !

Please note that this function is different from the usual “Quote Request”: to ask for a quote, including all pricing information, options and conditions of sales, you need to be registered on Bioseb.com.

Don’t hesitate to give us feedback on this new functionality or other aspects of our website - we’re always happy to improve Bioseb.com in order to suit your needs !
Society for Neuroscience 2011 - Washington
We would like to thank all of you who came to visit us on the Society for Neuroscience Meeting 2011 in Washington, especially Dominic Li from Eli Lilly Pharmaceutical Company for his work with our Dynamic Wright Bearing, and the team of Dr. Sarret from the University of Sherbrooke - as well as all our customers who used Bioseb's instruments and published their research results on the posters presented in Washintgon.

You were numerous to take the opportunity for discovering the latest innovations from Bioseb, like our "Automatic Dynamic Weight Bearing Test", our "Small Animal Algometer (SMALGO)" or our "Thermal Place Preference Test" et son nouveau design, and it was a pleasure for us to exchange viewpoints and experience on in-vivo testing with you. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!

Click here to enlarge the picture of our stand
In Vivo Research Instruments: New Online Videos
Bioseb.com is now offering researchers a new exclusive content: online videos that can be played YouTube-style, directly from the web page of the research instruments for all your applications in nociception, behaviour, motor activity and anxiety.

This new feature on Bioseb's website allows researchers to instantaneously get a video demonstration of some of the most acclaimed instruments developed by Bioseb:
Grip Strength Test, Activity Wheel, ActiV_meter, Dynamic Weight Bearing - Incapacitance, Thermal Gradient Test, Infrared Thermometer, Automated Forced Swimming Test, 2 Temperatures Choice Test, Electronic Von Frey

Other instruments developed by our partners also feature the new video content:
Rotarod, Black & White Test, Forced Swimming Test for Rats (Porsolt), Startle Fear, Samba Pressure System, Smart Video Monitoring

Just click on the name of an instrument in the lists above, and use the "Video" button to play the demonstration directly from your browser. More videos are available for registered users - please register on Bioseb.com and contact us to obtain the download link to specific videos.

If you are interested in obtaining a video for an instrument but cannot find it on our website, please contact us and we will do our best to put a new demonstration online.
Dynamic Weight Bearing - Publication
Bioseb team presents its respectful thanks to following research teams who used the Dynamic Weight Bearing (New Incapacitance Test) during their recent studies:

• Team of Prof. Sarret (University of Sherbrooke, Sherbrooke, Québec, Canada)
Imaging, Behavioural and Neurochemical Characteristics of a Clinically Relevant Bone Cancer Pain Model, by Louis Doré-Savard, Valérie Otis, Luc Tremblay, Karine Belleville, Mélanie Archambault et al.
(Click here to send a download request for this research poster as a PDF file)

• Team of Prof. Sarret (University of Sherbrooke, Sherbrooke, Québec, Canada)
Improving Pain Assessment In A New Mouse Model Of Bone Cancer Pain, by G. Roussy, K. Belleville, N. Beaudet and P. Sarret
(Click here to send a download request for this research poster as a PDF file)

• Team of Prof. Sarret (University of Sherbrooke, Sherbrooke, Québec, Canada)
NTS2 receptor activation as an innovative target for the treatment of neuropathic pain, by P.G. Tétreault, A. Guillemette, K. Belleville, J. Martinez, N. Beaudet and P. Sarret
(Click here to send a download request for this research poster as a PDF file)


Click on a picture to send a download request for a research poster


• Team of Dr. Ungard (McMaster University and Juravinski Cancer Centre, Hamilton, Ontario, Canada)
Examination of the mechanisms of cancer-induced bone pain in animal models, by Robert Ungard, Eric Seidlitz, Paolo De Ciantis, Vikas Sridhar, Kiran Yashpal, James L. Henry and Gurmit Singh
(Click here to send a download request for this research poster as a PDF file)

• Team of Dr. Bagi (WWCM, Global Science and Technology, Pfizer Inc., Groton)
Effect of VEGF inhibitor PF-00337210 and FAK/Pyk2 inhibitor PF-562,271 on Intra-tibial Growth of Breast Cancer Cells in Nude Rats and Mice, by Cedo M. Bagi, Rich Pero, Edwin Berryman, Daniel Aupi, Dean Wilkie and Cathy J. Andresen
(Click here to send a download request for this research poster as a PDF file)


Click on a picture to send a download request for a research poster
Bioseb wishes you a happy new year 2011!
We wish you
a happy new year 2011!

We are looking forward to be working with you for another year of successful partnership!


Please click here to enlarge our greeting card.

You can also download
our calendar 2011 by clicking here.
Polish Neuroscience Society Congress 2009 in Warsaw
The Polish Neuroscience Society Congress 2009 in Warsaw University will open soon and BIOSEB is proud to be present at the exhibition.

The Meeting Poster can be downloaded on following link:
Neuroscience 2009 in Warsaw - Bioseb Poster

We would like to invite those of you attending the Neuroscience 2009 meeting from September 9th to 12th to visit us: the last Neuroscience In Vivo Testing instruments will be presented there and ready to use. We are looking forward to seeing you in Warsaw!

The Bioseb Team
Activ_Meter (Actimeter for Rodents) - Publication
Bioseb team presents its respectful thanks to research teams of Prof. David (Université Paris-Sud) and Prof. Samuels (Columbia University, New York), who used the Activ_Meter (Actimeter for Rodents) during their recent studies:

Behavioral Effects of Fluoxetine in an Animal Model of Anxiety/Depression Are Mediated by Both Neurogenesis-Dependent and -Independent Mechanisms, by DJ. David, BA. Samuels, Q. Rainer, JW. Wang et al., in Neuron, 62, 2009
(Click here to download this article as a PDF file)

Abstract
Using Bioseb's Activ_Meter (Actimeter for Rodents), DJ. David, BA. Samuels, Q. Rainer, JW. Wang et al could describe a mouse model of an anxiety/depressive-like state induced by chronic corticosterone treatment, and showed that chronic antidepressant treatment reversed the behavioral dysfunctions and the inhibition of hippocampal neurogenesis induced by corticosterone treatment. Home cage activity was quantified using the ActiV-Meter (Bioseb, France) over a 24 hours period. During the experiment, food and water were provided ad libitum. Various parameters such as activity time (sec), ambulatory distance (cm) and inactivity duration (calculated from the difference between immobility and motionless activity duration while the animal is eating or scratching) were recorded.

These results demonstrate the interest of Bioseb's Bioseb's ActiV_Meter (Actimeter for rodents) for monitoring activity and locomotion of rodents (mouse and rat) in the home cage.

Click here to know more about Bioseb's ActiV_Meter (Actimeter for rodents)
Thermal Place Preference - Publication
Bioseb team presents its respectful thanks to research teams of Prof. Lazdunski (Université de Nice-Sophia Antipolis, France) and Prof. Eschalier (Clermont Université, Clermont-Ferrand, France), who used the Two-Temperatures Choice Test during their recent studies:

The mechano-activated Kþ channels TRAAK and TREK-1 control both warm and cold perception, by J. Noe, K. Zimmermann, J. Busserolles, E. Deval, A. Alloui,S. Diochot, N. Guy, M. Borsotto,P. Reeh, A. Eschalier and M. Lazdunski, EMBO Journal, 2009
(Click here to download this article as a PDF file)

Abstract
The sensation of cold or heat depends on the activation of specific nerve endings in the skin. This involves heat- and cold-sensitive excitatory transient receptor potential (TRP) channels. Using Bioseb's Two Temperaturs Choice Test, the research team could show that the mechano-gated and highly temperature-sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated. TRAAK and TREK-1 channels control pain produced by mechanical stimulation and both heat and cold pain perception in mice. Together TREK-1 and TRAAK channels are important regulators of nociceptor activation by cold, particularly in the nociceptor population that is not activated by menthol.

These results demonstrate the interest of Bioseb's Thermal Place Preference (2 Temperatures Choice Nociception Test) to study thermal nociception, thus being a very valuable tool for your research on analgesia.

Click here to know more about Bioseb's Thermal Place Preference (2 Temperatures Choice Nociception Test)
Cold and Hot Plate Test - Publication
Bioseb team presents its respectful thanks to research team of Prof. Poisbeau (Institut des Neurosciences Cellulaires et Intégratives de Strasbourg), who used the Cold and Hot Plate Test during its recent studies:

Differentiating Thermal Allodynia and Hyperalgesia Using Dynamic Hot and Cold Plate in Rodents, by I. Yalcin, A. Charlet, MJ. Freund-Mercier, M. Barrot and P. Poisbeau, in The Journal of Pain, 2009
(Click here to download this article as a PDF file)

Abstract
Yalcin, Charlet, Freund-Mercier, Barrot and Poisbeau, using Bioseb's Hot and Cold Plate Test, could show that escape behavior (jumps) was the most appropriate parameter in C57Bl/6J mice, whereas nociceptive response was estimated by using the sum of paw lickings and withdrawals in Sprague-Dawley rats. They could also demonstrate that this procedure allows the detection of both thermal allodynia and hyperalgesia after peripheral pain sensitization with capsaicin in mice and in rats. In a condition of carrageenan-induced paw inflammation, they observed the previously described thermal hyperalgesia, but also revealed that rats exhibit a clear thermal allodynia to a cold or a hot stimulus.

These results demonstrate the interest of Bioseb's Dynamic Hot and Cold plate to study thermal nociception, and more particularly to study both thermal allodynia and hyperalgesia within a single paradigm in awake and freely moving rodents.

Click here to know more about Bioseb's Cold and Hot Plate Test
Neurosciences 2009 - Bordeaux
We would like to thank all of you who came to visit us on the Neurosciences 2009 in Bordeaux. You were numerous to take the opportunity for discovering the latest innovations from Bioseb, like our "Dynamic Weight Bearing System", our "Thermal Gradient Test" or our "Automated Forced Swimming Test" (Automated Porsolt Test), and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!

Click here to enlarge the picture of our stand
Dynamic weight bearing : New incapacitance test
Measuring the Postural Equilibrium (weight bearing) on freely moving Mice or Rats, Bioseb's Dynamic Weight Bearing is an efficient alternative to traditional incapacitance tests for your research on analgesia/nociception.

Allowing to measure independantly the weight bore by each limb of a free moving animal, this very accurate system provides you with raw datas and computed values for each paw, which are synchronized with the images from a video camera.

Click here to get more information about our brand new Dynamic Weight Bearing
Bioseb wishes you a happy new year 2009!
We're looking forward to be working with you for another year of successful partnership!

Please click here to enlarge our greeting card.
Neuroscience 2008 in Washington: Bioseb on booth 629
We would like to invite those of you attending the Neuroscience 2008 meeting of the Society for Neuroscience in Washington DC on November 15 - 19 to visit us on the booth N°629. The last Neurosciences In Vivo Testing instruments will be presented there and ready to use. We are looking forward to seeing you in Washington!
ACTIV-METER: An Innovative Actimeter
Bioseb ACTIV_METER: a new actimeter for a continuous monitoring of mice and rats in their Home Cage. Innovative and performant: The Bioseb ActiV_Meter (rodent actimeter) allows to economically quantify 3 major parameters of the rodent behaviour : Movement / Motionless Activity / Immobility.

The animal remaining in its familiar environment, his position and activity can be recorded continuously during short as well as very long actimetry experiences. Specifically developed to perform analysis in the Home Cage, Bioseb's new actimeter can be used in any other kind of environment (open field, etc...).Accuracy is guaranteed with a sampling rate of 100 Hz.

Unlike other actimetry techniques, no intervention is required on the animal (rat or mouse), and our new actimeter, Bioseb's Activ_Meter, is not disturbed by any change (like litter movements) in the cage environment.

For more information about Bioseb's new actimeter, please click here
Measuring Behavior 2008 - Maastricht
We would like to thank all of you who came to visit us on the Measuring Behavior 2008 in Maastricht. You were numerous to take the opportunity for discovering the latest innovations from Bioseb, and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!

IASP 2008 - Glasgow
We would like to thank all of you who came to visit us on the IASP 2008 in Glasgow. You were numerous to take the opportunity for discovering the latest innovations from Bioseb, and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!

Cold and Hot Plate: for your research on analgesic drugs
Recent research has shown different receptors responses to "cold" and "hot" stimulations. The new Bioseb Cold and Hot Plate provides a larger range of temperatures (from 0°C to 70°C in a standard 20 to 25°C ambient ) in order to determine pain responses to either hot or cold stimuli, allowing rapid screening of narcotic analgesic drugs, or studying new responses in both mouse and rat.

Offering very fast temperature regulation (from ambient to 4°C in 10 min, and to 65°C in 5 min), the plate is accurate and stable (max. +/-0,2°C) all over the measurement range and all over the container surface, with a resolution of 0,1°C and 0,1sec. The USB interface allows data transfer of temperature, time response, date and time of the test. Very easy to use, simple to set up, the Bioseb Cold and Hot plate may soon become a standard screening tool in your lab.

For more information about the Cold and Hot Plate, please click here
FENS 2008 - Geneva
We would like to thank all of you who came to visit us on the FENS 2008 in Geneva. You were numerous to take the opportunity for discovering the latest innovations from Bioseb, like our "Cold and Hot Plate" or our "Dynamic Weight Bearing System", and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!

Click here to enlarge the picture of our stand
Bioseb/Scisense/iWorx: New Pressure-Volume System
The Scisense Pressure-Volume system simultaneously measures LV pressure and volume, in small mouse hearts. The PV Loops software from Iworx allows all PV computations and graphs.

For more information about the pressure-volume systems from Scisense, or for downloading a PDF catalogue of this product range, please click here.

To download the new iWorx 2007-2008 catalogue, please see corresponding news below.
New iWorx-Bioseb Catalog 2007-2008 Catalog
The New iWorx-Bioseb catalog 2007-2008 (english version) is available for download on Bioseb.com! A large line of full systems and components for physiological research is at your disposal, which you may also consult online on our website (click here to access the online catalog)

An exclusivity for registred users, the PDF catalog can be easily and quickly downloaded as follows:

1. Click here to access the catalog request page..
2. If you are not registred on Bioseb website yet, please use the registration form - if you are already a registred user, please go directly to step 3..
3. Enter the e-mail address used for your registration.
4. You will receive a download link by e-mail for the iWorx-Bioseb catalog as soon as our team will have processed your request.
BIOSEB: distribution agreement with SCISENSE
BIOSEB France is pleased to announce a distribution agreement with SCISENSE INC in CANADA, who offers a complete range of pressure and pressure/volume catheters systems for intracardiac phenotyping studies in mice, rats and bigger animals.

Our customers will find a complete solution together with the powerful data acquisition systems from IWORX and its Labscribe software.

The Scisense Pressure-Volume system simultaneously measures LV pressure and volume. It is the smallest such catheter in the world and creates the least possible disruption in small mouse hearts.

Click here to know more...
Samba: measuring pressure in a beating mouse heart
A revolutionary system - the new Bioseb-Samba system is the ideal solution for all your requirements in terms of blood pressure measurement on mice, rats and bigger species.

Pressure can be measured with higher precision and in places that were previously not possible: click here to download a video of the Samba Preclin 420 tranducer measuring pressure during an MRI scanning of a beating mouse heart.

For more information about this new tool to facilitate your scientific work and improve your results, please click here and visit the detailed product page.
Cold+Hot Plate Test - Publication
Bioseb team presents its respectful thanks to research team of Prof. Poisbeau (Institut des Neurosciences Cellulaires et Intégratives de Strasbourg), who used its instruments during its recent studies:

Functional exploration by radiotelemetry of freely moving rats exhibiting pain symptoms following carrageenan intraplantar injection
(Poster presented during the Neurosciences Congress in Montpellier, France, May 2007)

Charlet, Rajalu, Rodeau, and Poisbeau, using BIOSEB Cold+Hot Plate Test, could demonstrate that pain symptoms observed after acarrageenan injection are associated with significant locomotor impairment, postural disquilibrium and hyperthermia. They could also show that radiotelemetry of physiological/autonomic functions, used as a complement to Bioseb Cold+Hot Plate Test, was a useful technique to study pain reactions in freely moving animals.

Click here to send a download request for this publication
Neurosciences 2007 - Montpellier
We would like to thank all of you who came to visit us on the Neurosciences Congress 2007 in Montpellier, between the 22nd and the 25th of May 2007. You were numerous to take the opportunity for discovering the latest innovations from Bioseb, like our "2 Temperatures Choice Test" or our "ActiV_Meter", and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!

Click here to enlarge the picture of our stand
Four-plate-test: Publications
Bioseb team presents its respectful thanks to the following research groups, who used its instruments during their recent studies:

Effects of benzodiazepinic and GABAergic ligands on the anxiolytic-like activity of antidepressants in the four-plate test in mice
(Poster presented at the Congrès P2T Physiology, Pharmacology and Thérapeutics in Toulouse, April 2007)
This work by Hascoet, Dubois et al. presents results obtained using the ARON 4 Plates Test from Bioseb during research on anxiety by mice. They could demonstrate the clear effect of GABAergic system on citalopram, paroxetine, venlafaxine and milnaciprane mechanisms of action.

Click here to send a download request for this publication

Triggering factors for the abolishment of benzodiazepines effects in the four-plate test-retest
(Poster presented at the Congrès P2T Physiology, Pharmacology and Thérapeutics in Toulouse, April 2007)
The research team of B. Petit-Demoulière, M. Hascoet, M. Bourin et al could show, using the Four-Plate Test from Bioseb, a one-trial tolerance phenomenon for benzodiazepine.

Click here to send a download request for this publication
P2T Congress in Toulouse
A lot of researchers came to visit usduring the P2T Congress in Toulouse from the 11th till the 13th of April. This congress was an outstanding opportunity to introduce some of our new products to you, like our Thermal place preference test, our new Acti-V-Meter or the Infrared thermometer for cutaneous measurement. Thanks to all of you for visiting us!
Congress: Congress of the Brain Metabolism and Circulation S
Thanks to all numerous researchers who visited BIOSEB's stand during the Congress of the Brain Metabolism and Circulation Society on the 25th of January 2007 in Paris. These meetings are not only allowing us to show you our last innovations - they are also a pleasant occasion to define with you our new development directions, in order to offer even better instruments matching YOUR research needs. Looking forward to meeting you on our next congress - our website Bioseb.com provides up-to-date information about meeting opportunities.
Braintree-Bioseb 2006 Catalog
The New Braintree-Bioseb 2006 catalog (english version) is available for download on Bioseb.com! A large line of general laboratory equipment is at your disposal, which you may also consult online on our website (click here to access the online catalog)

An exclusivity for registred users, the PDF catalog can be easily and quickly downloaded as follows:

1. Click here to access the catalog request page..
2. If you are not registred on Bioseb website yet, please use the registration form - if you are already a registred user, please go directly to step 3..
3. Enter the e-mail address used for your registration.
4. You will receive a download link by e-mail for the Braintree-Bioseb catalog 2006 as soon as our team will have processed your request.
FENS Neurosciences Forum 2006 in Vienna
We would like to thank all of you who came to visit us on the FENS Forum 2006 in Vienna, between the 8th and the 12th of July 2006. You were numerous to take the opportunity for discovering the latest innovations from Bioseb and Panlab, and for exchanging viewpoints and experience on in-vivo testing. We will inform you on this website about the next scientific congresses to which Bioseb will participate... and we are looking forward to meeting you there!
Nociceptive tests: Neuronal response / Signal Synchro.
For very sensitive applications, the Aesthesiometer (dynamic Von Frey) from Ugo Basile has been modified to be able to synchronise stimulation and neuronal response recording. A TTL signal can be issued, application force is settable from 0,1g up, response time is 0,2 seconds.

Click here to get more information about our Dynamic Von Frey


For applications where the force level only has to be reached but not maintained, the Bioseb Instrumented Forceps" provides the same type of TTL output if a preset force threshold is reached. The TTL allows to start the recording.
Click here to get more information about our instrumented forceps
Units Converter
Because there is no measurement without units and you’re needing more and more units conversions for your international research projects, Bioseb offers an Online Units Converter to allow the conversion of all main units to any system of your choice:

Force: kN, daN, N, kgf, gf, lbf, pdl, dyn, kips
Torque: Nm, Ncm, kgmm, lbinch
Weight: t, kg, g, mg, lb, oz, c
Length: km, m, cm, mm, um, in, ft, french gauge
Temperature: °C, °F, °K
Pressure: Pa, kPa, MPa, N/m2, N/mm2, mb, bar, mmHg, cmHg, inHg, mmH2O, cmH2O, ftH2O, psi, psf, atm
Flow: m3/s, m3/min, m3/h, l/s, cfs, cfm, cfh
Illuminance: lx, fc, mc, lm/cm2, lm/in2, lm/ft2, lm/m2, phot, W/m2
Luminance: alb, sb, cd/cm2, cd/in2, cd/ft2, cd/m2, lb, bl


The Units converter is available from any webpage on our site by clicking on the link in the main menu.

You do not find the unit you are looking for? Send us an e-Mail and we’ll immediately add it to our converter for you.
List of international congress BIOSEB'products were exposed.
France (Lille) NEUROSCIENCES FRANCAISE
France (Bordeaux) PHARMACOLOGIE FRANCAISE
France (La rochelle) AFSTAL

Click here to enlarge the picture of our stand.
BIOSEB has re-designed ....
All its electronics for Von Frey and grip test. Together with a large backlighted screen the units comes with a statistic menu that calculates average and standard deviation on settables trials.

Bioseb - In Vivo Research Instruments
Phone worldwide : +33 442 344 360 - USA/Canada : (727) 521-1808
e-Mail : Worldwide: info@bioseb.com - USA/Canada: sales@eb-instruments.com