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APRIL 2019 - CONTENTS:

SPECIAL ISSUE - OARSI 2019
- The goal in developing Outcome Measures for Osteoarthritis on live rodents is to evaluate multiple parts of the pain experience including reflexive hyperalgesia measures, sensory and affective dimensions of pain and impact of pain on function and quality of life.
- Visit Bioseb at OARSI 2019 on booths 15 & 16: see how we innovated rodent outcome measures for osteoarthritis research

Foot Misplacement Apparatus
- Operator-independent scoring
- Flexible: remove bars to create difficulties
- Accurate: sensors above/below the ladder
- Automatic: differentiation fore/hind paws

Advanced Dynamic Weight Bearing
- Operator-independent
- No animal restraint - no stress
- New : software interface completely redesigned for a user-friendly browsing

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MARCH 2019 - CONTENTS:

SPECIAL ISSUE - All-in-One Algesimeter
- Bioseb makes measuring rodent nociception easy with a single software application and diverse stimulation probes

BIO-CIS Software
- Real-time curve tracing of the applied force
- Peak force determination
- Allows the definition of a theoretical ramp with up-down limits to be followed and displayed during the measurement – Great for Training!
- Curves of group of measures displayed simultaneously – Great for Figures!
- Export results to an Excel file or txt format

All-in-one Analgesimeter
- Electronic Von Frey, Rodent Pincher and Small animal Algometer is now available as a compact device!
- Economical solution
- Compact device for small bench footprint
- Flexible instrument when a quantitative sensory testing (QST) is needed

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FEBRUARY 2019 - CONTENTS:

SPECIAL ISSUE - Cambridge and Paris
- Bioseb is present at the XVth symposium of the Réseau Français de Recherche sur la Douleur in Paris, France, and at the Challenge of Chronic Pain, Cambridge, UK,

Dynamic Weight Bearing - REINVENTED
- Measures changes in postural equilibrium in freely moving rodents
- Operator-independent
- No animal restraint - no stress
- New : software interface completely redesigned for a user-friendly browsing

All-in-one Analgesimeter
- Electronic Von Frey, Rodent Pincher and Small animal Algometer is now available as a compact device!
- Economical solution
- Compact device for small bench footprint
- Flexible instrument when a quantitative sensory testing (QST) is needed

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JANUARY 2019 - CONTENTS:

BIOSEB'S WISHES FOR 2019!
- Success comes from great teamwork: our resolution for 2019 is to support you!
- Together, let's make this year the best in discovery yet!

Focus: Automated Ladder Test

- Allows qualitative & quantitative measure of rodent motor-coordination
- Automated recognition and anatomical assignment of paw misplacement
- Learning can be assayed with complex ladder configurations.
- Assure every FOOT FAULT is real and not a manual scoring misstep

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OCTOBER 2018 - CONTENTS:

SFN 2018 - SAN DIEGO, USA
Visit Bioseb’s exhibit at Neuroscience 2018 in San Diego, California, November 3-7th, Booth numbers 3932 & 3933.

Get a demonstration of our latest instruments, including:

- Advanced Dynamic Weight Bearing: Only operator-independent, spontaneous pain test not requiring animal restraint.
- Forced Swimming Test - Dual Sensor: Combining a double input from vibrations and video for more operator-independence
- Automated Ladder Test: Allows qualitative & quantitative measure of rodent motor-coordination

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SEPTEMBER 2018 - CONTENTS:

IASP 2018 - BOSTON, USA
Visit Bioseb on Booth #401 to learn more about: - How to conduct spontaneous pain test not requiring animal restraint
- How to conduct operator-independent pain assessment

Get a demonstration of the new version of our Dynamic Weight Bearing:

- Measures the weight borne on all 4 paws, tail, and other body parts
- Release animal-stress bias, thanks to its use on unrestrained subjects
- New : improved algorithms and higher acquisition frequency, for an enhanced accuracy in the results
- New : additional postures are now available for analysis
- New : software interface completely redesigned for a user-friendly browsing
- New : now 100% compatible with Guinea Pig study!

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JULY 2018 - CONTENTS:

FENS 2018 - BERLIN, GERMANY
Visit Bioseb on Booth #26 to learn more about: - How postural evaluation is strongly correlated to vestibular brain damage on rat.
- The validity of Bioseb's Dynamic Weight Bearing in the assessment of vestibular disease
- The poster "Use of the dynamic weight bearing as a sensible parameter for the diagnose of postural deficit following a vestibular injury in rodent", honored by the AFSTAL committee with the C.Authissier Prize

Get a demonstration of the new version of our Dynamic Weight Bearing:

- Measures the weight borne on all 4 paws, tail, and other body parts
- Release animal-stress bias, thanks to its use on unrestrained subjects
- New : improved algorithms and higher acquisition frequency, for an enhanced accuracy in the results
- New : additional postures are now available for analysis
- New : software interface completely redesigned for a user-friendly browsing
- New : now 100% compatible with Guinea Pig study!

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APRIL 2018 - CONTENTS:

OARSI 2018 - LIVERPOOL, UK
Visit Bioseb on booth #C1 and find the answers to your questions:
- How can I make my animals tell me about their pain sensation ?
- What instrument is the best on the market to explore rodents' joint pain & knee stability ?
- How to be sure about the accuracy and relevancy of the experimental results ?

Dynamic Weight Bearing - New version!

- Measures the weight borne on all 4 paws, tail, and other body parts
- Release animal-stress bias, thanks to its use on unrestrained subjects
- New : improved algorithms and higher acquisition frequency, for an enhanced accuracy in the results
- New : additional postures are now available for analysis
- New : software interface completely redesigned for a user-friendly browsing
- New : now 100% compatible with Guinea Pig study!

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FEBRUARY 2018 - CONTENTS:

BIOSEBLAB - NEW BRAINTREE CATALOGUE 2018
- New version of the BRAINTREE CATALOGUE 2018
- Free, downloadable PDF file to help you prepare your orders of Lab equipment
- BiosebLab: exclusive distributor in Europe for more than 13 years.
- Also available: a full range of equipment for the study of pain and behavior

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DECEMBER 2017 - CONTENTS:

SPECIAL EDITION - OUR HOLIDAY GREETINGS
- Merry Christmas and a happy new year 2018!

Our latest developments, which will help your research in 2018!
- Advanced Dynamic Weight Bearing: Automated analysis of weight distribution in freely moving rodents
- Automated Ladder Test: Qualitative and quantitative measures of rodent motor-coordination
- 3D Novel Object Recognition: Automatically track exploration patterns with 3D camera

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NOVEMBER 2017 - CONTENTS:

SPECIAL EDITION - SFN NEUROSCIENCE 2017 MEETING IN WASHINGTON, DC
- Bioseb's world-class portfolio of behavior instruments will be on display at the SFN Neuroscience 2017 meeting in Washington, DC, from the 11th to the 15th of November
- World's Only Automated Ladder Test! Discover a premier tool for Movement Disorder and Stroke Research during its first world-wide presentation at Neuroscience 2017

Our latest developments presented at SFN 2017:
- Advanced Dynamic Weight Bearing: Automated analysis of weight distribution in freely moving rodents
- Automated Ladder Test: Qualitative and quantitative measures of rodent motor-coordination
- 3D Novel Object Recognition: Automatically track exploration patterns with 3D camera

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OCTOBER 2017 - CONTENTS:

SPECIAL EDITION - TRAINING ON ANIMAL MODELS
- A solution for your needs for training on animal models
- A wide array of instruments allow you to train without using live animals, thus decreasing operator's stress as well as the number of animals used.

Contention, intubation, prélèvements sanguins - autant de techniques que vous pourrez acquérir avec nos 3 modèles de rat :
- BIO-RAT: Articulated model, anus & rectum allowing to practice temperature measurements, ears allow the placement of identification tags
- BIO-KOK: Posture identical to that of a living rat ;pharynx, larynx, trachea, stomach, and tail vein anatomically correct ; partially transparent abdomen allowing visual dosages
- MIMOLETTE: Allows blood sampling by cardiac punctures, and verification of intubations by swelling of the lungs

Training in micro-surgery and sutures :
- MD-PVC-MODEL: dedicated to training in micro-surgery: anastomoses, cannulations and transplantations of blood vessels and organs...
- ALT-SKINPADS: for the practice of incision, suture and autoclip closures, we offer artificial skin pads of 2 different sizes.

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SEPTEMBER 2017 - CONTENTS:

SPECIAL EDITION - HURRICANE HARVEY AND HURRICANE IRMA
- For those in the heavily impacted areas of Hurricane Harvey and Hurricane Irma, we are offering a 15% discount on purchases made through November 30, 2017.

Team North America: New recruit
- In an effort to STAY ON TOP of our game, Bioseb recruited our newest North American team member, Jessica Banko, PhD. Dr Banko joins Bioseb in the role of Business Development Director and Senior Scientific Liaison and brings to the post almost 20 years of experience working with animal models of human disease.

Bioseb USA Now on Linkedin!
- STAY ON TOP of interesting research and new product launches; access a collection of publications using our most current technology to aid you in protocol development and application; and find announcements of equipment funding opportunities among other resources.

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SEPTEMBER 2017 - CONTENTS:

Special Issue - European Orthopedic Research Society (EORS) Meeting 2017 - Munich
- Difficulties of analyzing motor-function in general, and gait deficit in particular: Bioseb's expertise
- 25th Annual and Anniversary Meeting of the European Orthopaedic Research Society (EORS): held 13-15 September 2017 in Munich, Germany - Meet Bioseb on booth #6

In terms of rodent gain measurement, how can we help you?
- Kinetic Weight Bearing (KWB): able to characterize natural gait parameters of freely walking rodents
- New Automated Ladder Test: a standard task where the rat/mouse is expected to cross a corridor, placing its paw on each ladder's rod

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JUNE 2017 - CONTENTS:

Special Issue - Mediterranean Neuroscience Society 2017 - Malta
- Do you have the right tool for your Neuroscience Research?
- Bioseb at the 6th Conference of MNS in Malta, June 12-15th, 2017

Perfect devices for pre-clinical studies
- PARKINSON / Grip Strength Test: An easy way to objectively quantify the muscular strength of rodents: ideal for studying myopathy & neurodegenerative diseases
- NEURODEGENERATIVE DISEASES & ALZHEIMER / Novel Object Recognition - 3D: An innovative setup for the automation of the Novel Object Recognition Test, based on 3D-camera based technology
- COGNITIVE DISORDERS & NEUROSURGERY / Stereotaxic frames: Electronic set-up and compact LCD: ideal for Neurosurgery and experiments on the Spinal Cord!

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APRIL 2017 - CONTENTS:

Special issue: 2017 Osteoarthritis Research Society International World Congress in Las Vegas
- Bioseb present on booth 6 for demonstration of ground-breaking instruments

Measuring devices for pain and weight bearing evaluation:
- Advanced Dynamic Weight Bearing Instrument: now available for guinea pigs! Ideal for your work on Joint destabilization.
- Electronic Von Frey instrument with embedbed camera! A new tool for limb withdrawal threashold, useful after meniscus surgery
- KWB: "New tool to assess walking patterns in the development of OA pain : Kinetic Weight Bearing", presented by K. Starowicz

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JANUARY 2017 - CONTENTS:

Happy new year 2017!
- Looking forward to a new year on your side, helping you by developing the tools you need for your ground-breaking research work!

Highlights of 2016:
- NORT3D: A brand new innovative setup for the automation of the Novel Object Recognition Test: set up our software in 3 clicks!
- EVF5: A quick and easy solution to determine the mechanical sensitivity threshold in rodents - now with embedded video!
- ACTIVWHEELS: High-res instrumented wheel with digital display or software to record 20 different variables pertaining to voluntary exercise

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NOVEMBER 2016 - CONTENTS:

Special Issue - SfN Meeting 2016 in San Diego
- Bioseb is attending the 46th annual Society for Neuroscience conference in San Diego

Demonstration of Bioseb's innovative instruments:
- Activity Meter and Wheel - Extended monitoring of spontaneous activity of rodents in home cage environment
- Kinetic Weight Bearing - Automated analysis of gait and weight distribution during spontaneous locomotion
- Advanced Dynamic Weight Bearing - Accurate and efficient video based incapacitance test in freely moving rodents
- NEW! Electronic Von Frey 5 - Powerful and still user friendly electronic device to determine mechanical sensitivity threshold in one trial. Now with embedded video!
- 3D Novel Object Recognition - Innovative design to automatically track exploration patterns with 3D camera for more discriminative analysis
- Two Temperature and Thermal Gradient Choice Test - Operator independent instrument to study thermal pain thresholds and temperature preference

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JUNE 2016 - CONTENTS:

Special Issue - FENS Meeting 2016 in Copenhagen
- Visit us at the FENS Meeting in Copenhagen, July 2nd - 6th, at booth #129

Novel Object Test
- Real-time scoring based on user-defined criteria
- Video Tracking with replay mode

Forced Swimming Test
- Monitor 4 animals simultaneously
- Automatic detection of 3-behavior states: climbing, swimming, floating

Gait analysis test
- Gait & Force assessment in one unique device !
- Automatic run detection and scoring

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MARCH 2016 - CONTENTS:

Special Issue - OARSI Meeting in Amsterdam
- OsteoArthritis Research Society International (OARSI) World Congress in Amsterdam, Netherland from 31st of March to 3rd of April

Evoked pain
- Electronic Von Frey: For sensibility threshold of rodent's plantar area
- Smalgo: With its specific stimulator for joint-application, extremely useful in OA-research
- Rodent Pincher: For the mechanical threshold in limbs and tail

Spontaneous pain
- Static Weight Bearing (SWB) is a simple device, and allows a basic measure of instability in the hind paws
- Dynamic Weight Bearing (DWB) allows pain assessment on all 4 paws, during a non-restrained exploration of the cage
- Kinetic Weight Bearing (KWB) give the results of the gait efforts applied by a rat or a mice, during a walking sequence

Pain-related behavior
- Activity monitoring for 24hr or more, with its Activmeter, an innovative way to quantify rodent's activity in its home-cage
- Spontaneous exercise observation, thanks to Running Wheels equipped with counter and software

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OCTOBER 2015 - CONTENTS:

Special Issue - How To Get Your Work Published
- 1. Use An Operator-independent Assay For Objective Data Collection
- 2. Use State-of-the-art Technology
- 3. Stand On The Shoulders Of Giants
- 4. Meet Us In Chicago And Discover How We Can Help You

Sfn Meeting 2015
- Meet Bioseb In Chicago On Booth 2055

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SEPTEMBER 2015 - CONTENTS:

Special Issue - Tip of the Month - Kinetic Weigt Bearing (KWB)
- Dual technology: video + sensors that yield information curves on the distribution of force over time for each paw
- Automated recognition of valid runs: saves valuable lab man hours and makes data acquisition more consistent
- Ground-breaking: Allows new research - phenotyping of CNS disorders such as stroke, neurodegenerative diseases, spinal cord injuries, trauma models (nerve crush, SNI, etc.)

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SEPTEMBER 2015 - CONTENTS:

QTK: Automated QUIETEK CO2 induction system s
- Follow ethical rules largely admitted by the scientific community (2013 AVMA guidelines)
- Manages different levels of concentration and thus to switch from unconsciousness to death in repeatable manner
- Reduces stress and pain experienced by the animal but also ensures the safety of the staff responsible for the procedure

RAPID-ID: Ear tags with QR Codes Millions of IDs
- A proprietary combination of alphanumeric digits providing millions of unique identification numbers
- Available in 5 colors
- Compatible with most available industry scanners

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AUGUST 2015 - CONTENTS:

TIP OF THE MONTH - DYNAMIC WEIGHT BEARING TEST
- Faster and more accurate paw identification: an efficient and advanced alternative to traditional incapacitance or static weight bearing test
- No over-stressing of the amimal: it is allowed to move freely and without restraint in the chamber
- Speed of operation and operator independence factor owing to the cutting-edge video and computer tracking software

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JUNE 2015 - CONTENTS:

TIP OF THE MONTH - AUTOMATED FORCED SWIMMING TEST
- TYC (Teach Your Computer) algorithm: train the software to use custom scored parameters
- Comparison of scoring protocols: eliminates time-consuming training for students and provides consistency across multiple studies
- Improve speed and accuracy: Bioseb's Forced Swim Test and software module are the premiere products in their class on the market today

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MAY 2015 - CONTENTS:

NEUPSIG and SfN Meetings 2015 in Nice and Monptellier: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2014 and 2015

Kinetic Weight Bearing: Automated analyzis of gait parameters
- Automatically analyze the weight borne on each paw.
- Unique technology: the floor is made of 3 sensor-mats that directly provide the true peak force in grams.
- Complementary synchronized gait parameters are also computed.

Activity Wheels: Anxiety-like and sex-dependent behaviors
- Provides information regarding troubles of circadian rhythms.
- Study the effect of voluntary exercise on anxiety-related behavior.
- Ideal for long-term studies and the acquisition can be paused or started anytime.

Dynamic Weight bearing: New applications
- A powerful and non-invasive method to phenotype variety of models.
- Our customer have now focused on PELVIC/ABDOMINAL pain with potential applications such as endometriosis diseases.

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NOVEMBER 2014 - CONTENTS:

SFN Meeting 2014 in Washington, DC: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2014

Novel Object Recognition Test: 3D sensor improves the test further!
- Adds discriminating parameters to the object exploration of rodents within an Open field test.
- Muzzle position, body orientation, time spent can now be combined with sniffing or rearing behaviors
- For studies on memory of objects and the associated brain structures and systems

Electronic Von Frey: now with embedded video!
- A quick and easy solution to determine the mechanical sensitivity threshold in rodents
- A new, integrated camera allows you to aim at the force application spot by looking at the screen
- Making the Electronic Von Frey even more convenient to use: more precise movement and better control!

Thermal Place Preference Version 2: Fully automatic!
- Ready for the next generation of computers and tablets and is much easier to use
- New algorithm for tracking activity and detecting zone transitions
- New improved electronics are more stable and result in faster temperature transitions

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OCTOBER 2014 - CONTENTS:

IASP Meeting 2014 in Buenos Aires: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2014

Activity wheel:A new innovative model for measuring non-reflexive pain
- 1 LCD display per wheel showing CW and CCW distances
- Fully compatible with chronobiology software
- Monitor up to 64 wheels linked on a bench or on a rack

Electronic Von Frey: now with embedded video!
- A quick and easy solution to determine the mechanical sensitivity threshold in rodents
- A new, integrated camera allows you to aim at the force application spot by looking at the screen
- Making the Electronic Von Frey even more convenient to use: more precise movement and better control!

Thermal Place Preference Version 2: Fully automatic!
- Ready for the next generation of computers and tablets and is much easier to use
- New algorithm for tracking activity and detecting zone transitions
- New improved electronics are more stable and result in faster temperature transitions

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July 2014 - CONTENTS:

FENS Meeting 2014 in Milan: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2014

Novel Object Recognition Test: Exclusive new 3D technology
- Adds discriminating parameters to the object exploration of rodents within an Open field test.
- Muzzle position, body orientation, time spent can now be combined with sniffing or rearing behaviors
- For studies on memory of objects and the associated brain structures and systems

Electronic Von Frey: now with embedded video!
- A quick and easy solution to determine the mechanical sensitivity threshold in rodents
- A new, integrated camera allows you to aim at the force application spot by looking at the screen
- Making the Electronic Von Frey even more convenient to use: more precise movement and better control!

Thermal Place Preference Version 2: Fully automatic!
- Ready for the next generation of computers and tablets and is much easier to use
- New algorithm for tracking activity and detecting zone transitions
- New improved electronics are more stable and result in faster temperature transitions

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April 2014 - CONTENTS:

American Pain Society (APS) Meeting 2014 in Tampa: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2013 and 2014

Dynamic Weight Bearing: phenotyping & pain severity in rodents
- The latest innovation from BIOSEB R&D team to evaluate non-evoked pain severity scale
- A clear correlation of pain level and weight bearing allows accurate pain assessment
- A useful pain severity scale that sensitively differentiates between various pain models

Thermal Place Preference: an exclusive automatic solution by Bioseb
- Allows researchers to work on unrestrained animals (mice and rats)
- Providing pure, objective data using a camera
- Operator-independent and highly accurate thanks to powerful new software!

Last minute: Camera-based electronic Von Frey prototype!
- A quick and easy solution to determine the mechanical sensitivity threshold in rodents
- A new, integrated camera allows you to aim at the force application spot by looking at the screen
- Making the Electronic Von Frey even more convenient to use!

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NOVEMBER 2013 - CONTENTS:

Society for Neuroscience Meeting 2013 in San Diego: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2013

Open Field: New 3D sensor to detect rearing & sniffing during exploration!
- 100% detection of allrearing, even the very short ones, thanks to exclusive sensor!
- No more extrapolation from the tracking detection - only true height measurement!
- Only three clicks arenecessary to run a test.

FST: Dual Sensor expertise for the automation of the Porsolt test in rats!
- An original setup that automatically detects 3 states during Porsolt's test
- States detected: Resting/Floating,Swimming, and Climbing/Struggling
- Teach the softwarehow to automatically differentiate the different states

KWB : Measures propulsive forces using gait analysis system
- A unique and very easy-to-use technology.
- Now available as a release version, featuring up to 6000 pressure sensors
- A powerful tool to evaluate models on spinal cord injuries
- Also useful for arthritis by Hemisection orinjection, brain trauma, neurodegenerative models and motor deficiencies

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MAY 2013 - CONTENTS:

Canadian Neuroscience Meeting 2013 in Toronto: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2012 and 2013

Forced Swimming: Reinvention of the Automated Dualsens Porsolt Test for rats!
- Physically measured, tracked and recorded are both the vibrations caused by a swimming animal as well as the video record of that same animal swimming or climbing.
- Multiple animals can be tested in batches of four for very high throughput!

KWB: Kinetic Weight Bearing Instrument
- A major breakthrough in the evaluation of weight distribution during a spontaneous walking session
- Kinetic analysis of the weight applied by each paw/ comparison between steps

Jump Test: Dynamic Cold/Hot Plate Test
- An entirely new set-up for the evaluation of escape behavior of mice experiencing a rise in temperature on an aluminum plate upon which the mice are in motion.
- Detect the jumps of the mouse within its cage and in total darkness!

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OCTOBER 2012 - CONTENTS:

Society for Neuroscience meeting 2012 in New Orleans: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2012

KWB: Kinetic Weight Bearing Instrument
- A major breakthrough in the evaluation of weight distribution during a spontaneous walking session
- Kinetic analysis of the weight applied by each paw/ comparison between steps

EPM3C: New '3­CLICKS' software for the elevated + maze and zero maze
- The new EPM­3C software from BIOSEB features unprecedented simplicity to run ELEVATED + MAZE or ZERO MAZE protocols
- User interface includes pre­defined zones with easy­-to-­adjust reporting of in/out times, speed of motion, time spent in each arms (open/closed), automatically !

Dynamic Weight Bearing: Non-evoked pain studies to avoid overdosing?
- New publication: Comparison of evoked and non­evoked endpoints in a rodent pain model and potential relevance to non­ evoked human pain, by Dr. Dominick Li, Eli Lilly

Automated Foot Misplacement: A unique tool to assess psychomotor skills
- A unique instrument on the market for the detailed modeling of walking and its disorders in mice and/or rats, with respect to motor and psychomotor skills and cognition.
- NOW available! Parallel digital video recording tool to enrich results and separate the left and right side.

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AUGUST 2012 - CONTENTS:

IASP Meeting 2012 in Milan: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2012

Thermal nociception: Bioseb's flexible range of cold/hot instruments
- 1. The Cold/Hot Plate, which is opening new investigation fields for your research on analgesia and nociception.
- 2. By combining 2 Cold/Hot plates in our Thermal Place Preference Test, you have the possibility to assess temperature preference by determining the preferred temperature of the animal
- 3. By adding a special designed corridor between the two plates you can demonstrate thermal place preference and assess temperature comfort threshold on rodents (mouse and rat) in a fully operator­-independent manner on freely moving rodents.

KWB: Kinetic Weight Bearing Instrument
- A major breakthrough in the evaluation of weight distribution during a spontaneous walking session
- Kinetic analysis of the weight applied by each paw/ comparison between steps

Other instruments: more innovation from Bioseb presented at FENS meeting 2012
- Automatic Forced Swimming Test, Rodent Pincher, Dynamic Weight Bearing, Fully automatic Tail Suspension Test...
- Come and visit Bioseb on FENS meeting 2012 to get a demonstration!

Last minute: new scientific posters mentioning Bioseb's instruments
- Bioseb team presents its respectful thanks to all research teams who used our In­Vivo research instruments during their recent studies, and mentioned our systems in numerous posters.

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JULY 2012 - CONTENTS:

FENS Meeting 2012: Come and meet Bioseb!
- Our technical and sales team will be very pleased to demonstrate the whole range of exclusive instruments developed by our R&D teams in 2012


KWB: Kinetic Weight Bearing Instrument
- A major breakthrough in the evaluation of weight distribution during a spontaneous walking session
- Kinetic analysis of the weight applied by each paw/ comparison between steps

Other instruments: more innovation from Bioseb presented at FENS meeting 2012
- Automatic Forced Swimming Test, Rodent Pincher, Dynamic Weight Bearing, Fully automatic Tail Suspension Test...
- Come and visit Bioseb on FENS meeting 2012 to get a demonstration!

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JUNE 2012 - CONTENTS:

Activity wheels:
- A new innovative model for measuring non-evoked pain !
- New publication in Boston Children?s Hospital: highlights the use of Bioseb's wheel as a non-reflexive measure of pain levels

Dynamic Weight Bearing : New automated upgrade available !
- New development: save valuable time in evaluating the weight borne by each individual paw of a rodent subject.
- Ask Bioseb to upgrade your Dynamic Weight Bearing System

Grip Strength Test in ALS Research
- New publication by Garbuzova-Davis of the University of South Florida.
- Grip Test can be used as quantitative measure to demonstrate the progression of the disease.

Bioseb.com: Software Versions and Updates
- Find information about our software, including the latest version available and the OS compatibility.
- Interact with our R&D team: get information, updates and support.

Upcoming meetings: meet Bioseb's team on following congresses
- FENS Barcelona - July 14-18, 2012 - Centre Convencions Internacional Barcelona (CCIB) - Spain
- IASP Milan - August 27-31, 2012 - Milano Convention Centre - Italy
- SFN New Orleans - October 13-17 - Ernest N. Morial Convention Center - USA

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NOVEMBER 2011 - CONTENTS:

Scientific Congress
- Neuroscience meeting 2011: our latest instruments in Washington

New developments:
1. DWB-Video: The new automated version of our popular Dynamic Weight Bearing Systems
2. Smalgo-GT: A modified version of our SMall animal ALGOmeter, for big animals (cats, dogs, pigs, horses?)
3. Operand Escaping Test: unique set of cages for our Thermal Place Preference Test, to explore pain modulation mechanisms
4. Thermal Place Preference Test: New design : a single casing for both plates, with independant and advanced temperature control

Anxiety & Depression
- FST X'PERT: track combined sensor based Forced Swimming Test for Mice
- Tail Suspension Test: high-throughput systen, up to 6 mice, entirely automated

Nociception & Analgesia
- Algometer family: for rodents and bigger animals, mechanical pain threshold for OA models, low back pain, tendon related pain etc.
- Cold + Hot Plate: large range of temperatures (?3 to +65°C), can ramp to a defined temperature and run in temperature cycles
- Coming soon: video based software to count jumps distribution over time, please visit us to be the first to test !
- Gradient Thermal Test: automated instrument offering a 1,25m long thermal gradient to assess temperature of comfort.

Activity & Behavior
- Activmeter: dedicated to home cage activity evaluation, especially designed for long term experiments.

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MAY 2011 - CONTENTS:

Scientific Congress
- Canadian Neuroscience Meeting 2011 in Quebec City from May 29th to June 1st

Anxiety & Depression
- Automated Force Swimming Test: combining a vibratory signal with a synchronized video, with Expert scoring feature.
- Automated Tail Suspension Test: load cell based system, records and quantifies Immobility time, Energy value and Power in motion.

Nociception & Analgesia
- Dynamic Weight Bearing: measures the weight bearing over the four paws of a freely moving animal.
- Small Animal Algometer: developed to be used in models of low back pain and joint pain related to OA, can get a pain threshold on any region of the animal.
- Two Temperatures Choice Test: operator-independent test, automatic recording by video tracking system.
- Gradient Thermal Test: automated instrument offering a 1,25m long thermal gradient to assess temperature of comfort.

Activity & Locomotion
- Activmeter: dedicated to home cage activity evaluation, especially designed for long term experiments.
- Grip Strength Meter : a well known and referenced instrument that can be used both in rats and mice .

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JULY 2010 - CONTENTS:

Scientific Congress
- 7th Forum of European Neurosciences (FENS) is opening in Amsterdam

Anxiety & Depression
- Automated Force Swimming Test in mice: our sensor-based FST has a unique Expert comparative scoring analysis option.

Nociception & Analgesia
- Bioseb's SMALGO (SMall animal ALGOmeter) fits on your finger and allows to apply a force or pressure on the desired location
- Dynamical Weight Bearing Test: allowing to measure independantly the weight bore by each limb of a free moving rodent

Thermal stimulation
- Thermal Place Preference: the new ?2 Temperature Choice Test?, totally operator independant
- Cold + Hot Plate: large range of temperatures (?3 to +65°C), can ramp to a defined temperature and run in temperature cycles
- Gradient Thermal Test: an automated instrument offering a temperature gradient to assess thermal place preference and comfort threshold.

Activity & Behaviour:
- Activmeter: New instrument from our R&D, allows continuous monitoring of the activity and movements of mice or rats in their ?home cage?

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MARCH 2010 - CONTENTS:

Pain & Nociception
- Dynamic Weight Bearing (DWB) - Coming soon: automatic paw position detection
- Rodent pincher: new design available! New branches and a more heavy body for a more stable handling.

Promotional offer
- Free home cage for our ActivMeter !

Scientific congresses and meetings
- IASP Montreal 29 August- 02 september 2010
- FENS Amsterdam July 03-07 2010
- SFN 2010 November 13-17 2010

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Bioseb - In Vivo Research Instruments
Phone worldwide : +33 442 344 360 - USA/Canada : (727) 521-1808
e-Mail : Worldwide: info@bioseb.com - USA/Canada: sales@eb-instruments.com