Candesartan restores pressure-induced vasodilation and prevents skin pressure ulcer formation in diabetic mice

Authors
Aurore Danigo, Mohamad Nasser, Flavien Bessaguet, James Javellaud, Nicole Oudart, Jean-Michel Achard, and Claire Demiotcorresponding author


Lab
EA6309, School of Medecine and Pharmacy, University of Limoges, Limoges, France

Journal
Cardiovasc Diabetol

Abstract
Angiotensin II type 1 receptor (AT1R) blockers have beneficial effects on neurovascular complications in diabetes and in organ’s protection against ischemic episodes. The present study examines whether the AT1R blocker candesartan (1) has a beneficial effect on diabetes-induced alteration of pressure-induced vasodilation (PIV, a cutaneous physiological neurovascular mechanism which could delay the occurrence of tissue ischemia), and (2) could be protective against skin pressure ulcer formation.

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