Maladie d'Alzheimer - Publications Scientifiques

Dernière publication 01/03/2025

Social and contextual memory impairments induced by Amyloid-β oligomers are r

Sigma-1 receptors (S1Rs) are widely expressed throughout the central nervous system and modulate neuron intracellular calcium levels, leading to...

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    [title] => Social and contextual memory impairments induced by Amyloid-β oligomers are r
    [paragraph] => Social and contextual memory impairments induced by Amyloid-β oligomers are rescued by Sigma-1 receptor activation
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Authors
Souhail Djebari, Raquel Jiménez-Herrera, Guillermo Iborra-Lázaro, Lydia Jiménez-Díaz, Juan D. Navarro-López



 Lab


Journal
Biomedicine & Pharmacotherapy


Abstract
Sigma-1 receptors (S1Rs) are widely expressed throughout the central nervous system and modulate neuron intracellular calcium levels, leading to chang…


Keywords/Topics
Alzheimer’s disease;Amyloid-β oligomers;Social memory;Spatial memory;Hippocampus;Sigma-1;PRE-084;LTP
BIOSEB Instruments Used:
Tail Suspension Test - Wireless (BIO-TST5)

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La version 5 du Test de Suspension Caudale de Bioseb, basée sur des capteurs de force ainsi que sur de l'acquisition vidéo, est la seule et unique solution totalement automatisée au monde pour effectuer un test de désespoir comportemental simple et objectif sur souris. Il s'agit d'une méthode rapide, fiable et sans douleur pour tester les effets psychotropes de drogues et substances comme les antidépresseurs et les sédatifs. Ce test classique et indolore pour la recherche sur l'anxiété et la dépression est désormais présenté avec un nouveau logiciel puissant et moderne, dans une version sans-fil BlueTooth.


Instrument for mice

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