Codonopsis lanceolata and Its Active Component Tangshenoside I Ameliorate Skeletal Muscle Atrophy via Regulating the PI3K and Akt and SIRT1 and PGC-1alpha Pathways

TY Kim, KT Park, SY Choung

Kyung Hee University, Seoul, Republic of Korea.


Skeletal muscle atrophy is caused by aging, disuse, malnutrition, and several diseases. However, there are still no effective drugs or treatments for muscle atrophy. Codonopsis lanceolata (CL), a traditional medicinal plant and food, has been reported to have anti-oxidative, anti-inflammatory, anti-tumor, and anti-obesity effects. This study aimed to investigate the efficacy and active component of CL on muscle atrophy in vitro and to confirm the effect of CL and its active component on muscle atrophy and the underlying molecular mechanisms in vivo.

BIOSEB Instruments Used:
Grip strength test (BIO-GS3)

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