Authors
F. Marchand, A. Alloui, T. Pelissier, A. Hernández, N. Authier et al.
Lab
Faculté de Médecine, Laboratoire de Pharmacologie Médicale, E 9904 INSERM/UdA, Clermont-Ferrand, France.
Journal
Brain Research
Abstract
Venlafaxine, a new antidepressant with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment. In the present study, we demonstrated that venlafaxine inhibits hyperalgesia in a new rat model of neuropathy induced by the antineoplasic drug vincristine, and exerts its effect preferentially via supraspinal and spinal mechanisms.