Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced neuropathy in rat-

Authors
F. Marchand, A. Alloui, T. Pelissier, A. Hernández, N. Authier et al.


Lab
Faculté de Médecine, Laboratoire de Pharmacologie Médicale, E 9904 INSERM/UdA, Clermont-Ferrand, France.

Journal
Brain Research

Abstract
Venlafaxine, a new antidepressant with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment. In the present study, we demonstrated that venlafaxine inhibits hyperalgesia in a new rat model of neuropathy induced by the antineoplasic drug vincristine, and exerts its effect preferentially via supraspinal and spinal mechanisms.

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