Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-methyl-D-aspartate Receptors

Authors
CAN Ismail, R Suppian, CBA Aziz, K Haris, I Long


Lab
School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu, Malaysia

Journal
Diabetes and Metabolism Journal

Abstract
DM rats showed a significant reduction in pain threshold in response to the tactile and thermal stimuli and higher nociceptive response during the formalin test accompanied by the higher expression of phosphorylated spinal NR2B in both sides of the spinal cord. Ifenprodil treatment for both doses showed anti-allodynic and anti-nociceptive effects with lower expression of phosphorylated and total spinal NR2B. Conclusion: We suggest that the pain process in the streptozotocin-induced diabetic rat that has been modulated is associated with the higher phosphorylation of the spinal NR2B expression in the development of PDN, which is similar to other models of neuropathic rats.

BIOSEB Instruments Used:
Cold Hot Plate Test (BIO-CHP),Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)

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