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Von Frey Électronique 5 avec caméra intégrée
Référence : BIO-EVF5
Catégorie : Douleur - Allodynie/Hyperalgésie Mécanique
En tant que version électronique du classique esthésiomètre à filaments de Von Frey, la dernière évolution de l’instrument électronique Von Frey de Bioseb, conçu pour déterminer le seuil de sensibilité mécanique chez les rongeurs (rats et souris) par stimulation sous la patte, est un outil indispensable pour vos recherches sur l’hyperalgésie et l’allodynie. En mesurant et en enregistrant la force à laquelle l’animal présente un réflexe de retrait de la patte, il est possible d’étudier les pathologies liées à la réponse sensorielle ainsi qu’à l’hyper- ou l’hypoesthésie.
L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire
Présentation
Nouveau logiciel EVF avec vidéo integrée
16 ans après la création du premier Von Frey Electronique de Bioseb, nous révolutionnons l’utilisation de ce test standard pour la mesure du seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris).
Bien connu pour ses difficultés d’utilisation lorsque l’on veut stimuler sous la patte des rongeurs, le test de Von Frey Electronique est généralement critiqué par les opérateurs pour les troubles liés au fait de devoir se pencher et pour la position inconfortable à maintenir pour effectuer son geste. Malgré l’utilisation de postes de travails adaptés (sièges bas, stands surélevés...), la manipulation reste difficile, voire douloureuse lorsque répétée sur un grand nombre d’animaux.
Afin d’y remédier, nous avons intégré une caméra au niveau de la poignée d’utilisation de notre appareil pour pouvoir filmer directement par-dessous les pattes. Couplé à l’utilisation d’un logiciel dédié, nous avons repensé la manière dont l’opérateur peut se positionner pour effectuer le test.
Utilisé sur une tablette tactile, le logiciel EVF 5 permet ainsi de visionner le flux vidéo en temps réel sans que l’opérateur ait à se pencher. De plus, il intègre l’ensemble des fonctionnalités qui peuvent être recherchées pour ce test :
• La gestion des listes d’animaux.
• L’affichage en temps réel de la courbe de force en fonction du temps pour améliorer son geste et la reproductibilité des mesures.
• Un tableau permettant d’assigner une mesure à la patte correspondante, directement en cliquant sur l’écran tactile.
• Une relecture à la fois des vidéos et de la courbe de force pour chacune des mesures afin d’éliminer celles qui ne conviennent pas.
• Un export des résultats dans un tableau Excel.
Principes de fonctionnement
Composé d’une poignée de stimulation reliée à une tablette tactile intégrant un logiciel dédié, l’appareil est pensé pour que l’opérateur n’ait pas à se pencher et puisse avoir un environnement complet pour le Test de Von Frey.
L’opérateur crée une expérience sur le logiciel dédié et paramètre sa liste d’animaux ainsi que les différentes pattes qu’il souhaite stimuler (généralement pattes arrières). Il peut ensuite démarrer le test en prenant en main la poignée de stimulation et observe sous les pattes des rongeurs directement à travers le flux vidéo sur la tablette tactile et non en se penchant sous les pattes.
La stimulation est généralement effectuée sur les pattes arrières du rongeur. Le retrait de la patte causé par la stimulation mécanique est enregistré comme la réponse à ce stimulus. Lors de la mesure, l’opérateur peut suivre en direct et ainsi adapter la force appliquée en fonction du temps.
La force maximale appliquée avec l’appareil, correspondant à la valeur nécessaire pour le retrait de la patte, est sauvegardée par le système. L’opérateur peut directement décider de valider cette mesure en cliquant sur l’écran tactile (voir photo dans la partie logiciel ci-dessous) ou relancer la mesure avec une nouvelle stimulation. 
Livré avec
• 1 Mallette
• Une pédale à pied pour la mise à zéro au démarrage du test en gardant les 2 mains libres
• 10 Pointes de mesure jetables de 0,5 mm de diamètre
• Une pointe ressort pour seuils de 0-10 grammes
BIO-EVF5
Fiche technique
- Mémoire interne
- jusqu'à 100 valeurs
- Alimentation
- secteur 220-240V (autres voltages sur demande)
- Plage
- 0-500 grammes (5N
- Résolution
- 0.1 gramme
- Applications
- Arthrite & Arthrose
Cognitive performance
Douleur
Fonctions de motricité générale
Métabolisme
Neurodégénérescence
Système Nerveux Central (SNC)
Système sensoriel
Thématiques transversales
Troubles de l'humeur - Précision
- +/-0.25% de la plein échelle ( +/- 1,25g)
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[title] => CREB1 Facilitates GABAergic Neural Differentiation of Human Mesenchymal Stem Cells through BRN2 for Pain Alleviation and Locomotion Recovery after Spinal Cord Injury
[paragraph_crop] => CREB1 Facilitates GABAergic Neural Differentiation of Human Mesenchymal Stem Cells through [...]
[image_presente] =>
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[title] => Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced Peripheral Neuropathy- A Comparative Pilot Study with Oxaliplatin- Paclitaxel- Bortezomib- and Vincristine
[paragraph_crop] => Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced [...]
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[title] => Minimally Invasive Periarticular Injections Of Local Anesthetic Provides Prolonged Analgesia In A Rodent Osteoarthritis Model
[paragraph_crop] => Minimally Invasive Periarticular Injections Of Local Anesthetic Provides Prolonged Analgesia [...]
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[title] => Enhanced pain facilitation rather than impaired pain inhibition in burning mouth syndrome female patients
[paragraph_crop] => Enhanced pain facilitation rather than impaired pain inhibition in burning mouth syndrome [...]
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[title] => Targeting TRPV1 activity via high‐dose capsaicin in patients with sickle cell disease
[paragraph_crop] => Targeting TRPV1 activity via high‐dose capsaicin in patients with sickle cell disease
[image_presente] =>
[date] => 2022-06-27 00:00:00
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[title] => RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication- reducing pain and inflammation in gouty arthritis in mice
[paragraph_crop] => RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication- [...]
[image_presente] =>
[date] => 2022-06-18 00:00:00
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[title] => Sciatic nerve stimulation alleviates acute neuropathic pain via modulation of neuroinflammation and descending pain inhibition in a rodent model
[paragraph_crop] => Sciatic nerve stimulation alleviates acute neuropathic pain via modulation of [...]
[image_presente] =>
[date] => 2022-06-15 00:00:00
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[title] => The Overexpression of Insulin-Like Growth Factor-1 and Neurotrophin-3 Promote Functional Recovery and Alleviate Spasticity After Spinal Cord Injury
[paragraph_crop] => The Overexpression of Insulin-Like Growth Factor-1 and Neurotrophin-3 Promote Functional [...]
[image_presente] =>
[date] => 2022-04-29 00:00:00
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[title] => Moelle épinière
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[title] => Early life pain experience changes adult functional pain connectivity in the rat somatosensory and the medial prefrontal cortex
[paragraph_crop] => Early life pain experience changes adult functional pain connectivity in the rat somatosensory [...]
[image_presente] =>
[date] => 2022-03-04 00:00:00
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[title] => Painful Diabetic Neuropathy Is Associated with Compromised Microglial IGF-1 Signaling Which Can Be Rescued by Green Tea Polyphenol EGCG in Mice
[paragraph_crop] => Painful Diabetic Neuropathy Is Associated with Compromised Microglial IGF-1 Signaling Which [...]
[image_presente] =>
[date] => 2022-02-22 00:00:00
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[title] => Diabète, Insuline & Glucose
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[title] => The Therapeutic Effect of iMSC-Derived Small Extracellular Vesicles on Tendinopathy Related Pain Through Alleviating Inflammation- An in vivo and in vitro Study
[paragraph_crop] => The Therapeutic Effect of iMSC-Derived Small Extracellular Vesicles on Tendinopathy Related [...]
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[url] => https://bioseb.com/fr/news/probdnfp75ntr-promotes-rheumatoid-arthritis-and-inflammatory-response-by-activating-proinflammatory-cytokines-n1502
[title] => proBDNF/p75NTR promotes rheumatoid arthritis and inflammatory response by activating proinflammatory cytokines
[paragraph_crop] => proBDNF/p75NTR promotes rheumatoid arthritis and inflammatory response by activating proinflammatory
[image_presente] =>
[date] => 2022-01-05 00:00:00
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[title] => Alpha-Conotoxin RgIA and oligoarginine R8 in the mice model alleviate long-term oxaliplatin induced neuropathy
[paragraph_crop] => Alpha-Conotoxin RgIA and oligoarginine R8 in the mice model alleviate long-term oxaliplatin [...]
[image_presente] =>
[date] => 2022-01-01 00:00:00
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[title] => Small Extracellular Vesicles Derived From Human Ipsc-Derived MSC Ameliorate Tendinopathy-Related Acute Pain Through Inhibiting Mast Cells Activation
[paragraph_crop] => Small Extracellular Vesicles Derived From Human Ipsc-Derived MSC Ameliorate [...]
[image_presente] =>
[date] => 2021-12-06 00:00:00
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[url] => https://bioseb.com/fr/news/involvement-of-the-bdnftrkbkcc2-pathway-in-neuropathic-pain-after-brachial-plexus-avulsion-n1496
[title] => Involvement of the BDNFÐTrkBÐKCC2 pathway in neuropathic pain after brachial plexus avulsion
[paragraph_crop] => Involvement of the BDNFÐTrkBÐKCC2 pathway in neuropathic pain after brachial plexus avulsion
[image_presente] =>
[date] => 2021-11-21 00:00:00
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[url] => https://bioseb.com/fr/news/wntbeta-catenin-pathway-in-experimental-model-of-fibromyalgia-role-of-hidrox-n1479
[title] => Wnt/beta-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox
[paragraph_crop] => Wnt/beta-Catenin Pathway in Experimental Model of Fibromyalgia: Role of Hidrox
[image_presente] =>
[date] => 2021-11-13 00:00:00
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[url] => https://bioseb.com/fr/news/contribution-of-trem2-signaling-to-the-development-of-painful-diabetic-neuropathy-by-mediating-microglial-polarization-in-mice-n1443
[title] => Contribution of Trem2 Signaling to the Development of Painful Diabetic Neuropathy by Mediating Microglial Polarization in Mice
[paragraph_crop] => Contribution of Trem2 Signaling to the Development of Painful Diabetic Neuropathy by Mediating [...]
[image_presente] =>
[date] => 2021-10-26 00:00:00
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[title] => Reversing the surface charge of MSC-derived small extracellular vesicles by epsilonPL-PEG-DSPE for enhanced osteoarthritis treatment
[paragraph_crop] => Reversing the surface charge of MSC-derived small extracellular vesicles by epsilonPL-PEG-DSPE [...]
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[date] => 2021-10-04 00:00:00
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[title] => Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha and Beta-Hydrolase Domain 6 Knockout Rat
[paragraph_crop] => Phenotypic Characterization of the Endocannabinoid-Degrading Enzyme Alpha and Beta-Hydrolase [...]
[image_presente] =>
[date] => 2021-08-31 00:00:00
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[title] => Allodynie mécanique & Hyperalgésie
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[url] => https://bioseb.com/fr/news/behavioral-phenotyping-of-cancer-pain-in-domesticated-cats-with-naturally-occurring-squamous-cell-carcinoma-of-the-tongue--initial-validation-studies-provide-evidence-for-regional-and-widespread-algoplasticity-n1456
[title] => Behavioral phenotyping of cancer pain in domesticated cats with naturally occurring squamous cell carcinoma of the tongue- initial validation studies provide evidence for regional and widespread algoplasticity
[paragraph_crop] => Behavioral phenotyping of cancer pain in domesticated cats with naturally occurring squamous [...]
[image_presente] =>
[date] => 2021-08-16 00:00:00
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[url] => https://bioseb.com/fr/news/novel-functionalized-amino-acids-as-inhibitors-of-gaba-transporters-with-analgesic-activity-n1451
[title] => Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity
[paragraph_crop] => Novel Functionalized Amino Acids as Inhibitors of GABA Transporters with Analgesic Activity
[image_presente] =>
[date] => 2021-08-04 00:00:00
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[url] => https://bioseb.com/fr/news/modulatory-effect-of-probiotic-lactobacillus-rhamnosus-pb01-on-mechanical-sensitivity-in-a-female-diet-induced-obesity-model-n1424
[title] => Modulatory Effect of Probiotic Lactobacillus rhamnosus PB01 on Mechanical Sensitivity in a Female Diet-Induced Obesity Model
[paragraph_crop] => Modulatory Effect of Probiotic Lactobacillus rhamnosus PB01 on Mechanical Sensitivity in a [...]
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[date] => 2021-06-29 00:00:00
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[url] => https://bioseb.com/fr/news/genistein-reverses-the-effect-of-17betaestradiol-on-exacerbating-experimental-occlusal-interferenceinduced-chronic-masseter-hyperalgesia-in-ovariectomized-rats-n1422
[title] => Genistein reverses the effect of 17beta_estradiol on exacerbating experimental occlusal interference_induced chronic masseter hyperalgesia in ovariectomized rats
[paragraph_crop] => Genistein reverses the effect of 17beta_estradiol on exacerbating experimental occlusal [...]
[image_presente] =>
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[title] => Astrocytes in the rostral ventromedial medulla contribute to the maintenance of orofacial hyperalgesia induced by late removal of dental occlusal interference
[paragraph_crop] => Astrocytes in the rostral ventromedial medulla contribute to the maintenance of orofacial [...]
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[date] => 2021-05-27 00:00:00
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[url] => https://bioseb.com/fr/news/ferroptosis-is-involved-in-the-development-of-neuropathic-pain-and-allodynia-n1405
[title] => Ferroptosis is involved in the development of neuropathic pain and allodynia
[paragraph_crop] => Ferroptosis is involved in the development of neuropathic pain and allodynia
[image_presente] =>
[date] => 2021-04-17 00:00:00
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[url] => https://bioseb.com/fr/news/oral-supplementation-with-fish-cartilage-hydrolysate-accelerates-joint-function-recovery-in-rat-model-of-traumatic-knee-osteoarthritis-n1404
[title] => Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in rat model of traumatic knee osteoarthritis
[paragraph_crop] => Oral supplementation with fish cartilage hydrolysate accelerates joint function recovery in [...]
[image_presente] =>
[date] => 2021-04-10 00:00:00
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[title] => Extracellular vesicles released from hiPSC-derived MSCs attenuate chronic prostatitis and chronic pelvic pain syndrome in rats by immunoregulation
[paragraph_crop] => Extracellular vesicles released from hiPSC-derived MSCs attenuate chronic prostatitis and [...]
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[title] => Preemptive Stem Cells Ameliorate Neuropathic Pain in Rats- A Central Component of Preemptive Analgesia
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[title] => Anti-Inflammatory and Analgesic Effects of TRPV1 Polypeptide Modulator APHC3 in Models of Osteo-and Rheumatoid Arthritis
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[title] => Inhibiting cough by silencing large pore-expressing airway sensory neurons with a charged sodium channel blocker 2
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[title] => The adjuvant-induced rat model of monoarthritis- welfare implications and possible refinement strategies
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[title] => Albiflorin Attenuates Mood Disorders Under Neuropathic Pain State By Suppressing The Hippocampal NLRP3 Inflammasome Activation During Chronic Constriction Injury
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[title] => Repeated Intrathecal Administration of Ropivacaine Hydrochloride Induces Apoptosis Via Up-Regulating of Fas and FasL Expression in the Rat Spinal Cord
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[title] => Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of AlzheimerÕs disease
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[title] => Alterations of distributed neuronal network oscillations during acute pain in freely-moving mice
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[date] => 2020-08-11 00:00:00
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[title] => Ultrafast ultrasound imaging pattern analysis reveals distinctive dynamic brain states and potent sub-network alterations in arthritic animals
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[title] => The effect of pirfenidone on rat chronic prostatitis and chronic pelvic pain syndrome and its mechanisms
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[title] => The Role of Cashew -Anacardium occidentale L-- Nuts on an Experimental Model of Painful Degenerative Joint Disease
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[title] => NeuroHeal Treatment Alleviates Neuropathic Pain and Enhances Sensory Axon Regeneration
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[title] => Effect of Artesunate on Leishmania Amazonesis Induced Neuroinflammation and Nociceptive Behavior in Male Balb and C Mice
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[title] => Dim light at night exposure induces cold hyperalgesia and mechanical allodynia in male mice
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[title] => GABAergic modulation of secondary hyperalgesia- A randomized controlled 4_way crossover trial with the alpha2_subunit preferring GABA positive allosteric modulator- N_desmethyl_clobazam in healthy volunteers
[paragraph_crop] => GABAergic modulation of secondary hyperalgesia: A randomized controlled 4_way crossover trial [...]
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[title] => Disabling phosphorylation at the homer ligand of the metabotropic glutamate receptor 5 alleviates complete Freund's adjuvant-induced inflammatory pain
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[title] => N-acetyl-L-cysteine reduces Leishmania amazonensis-induced inflammation in BALB and c mice
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[url] => https://bioseb.com/fr/news/tanshinone-iia-contributes-to-the-pathogenesis-of-endometriosis-via-renin-angiotensin-system-by-regulating-the-dorsal-root-ganglion-axon-sprouting-n1184
[title] => Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system by regulating the dorsal root ganglion axon sprouting
[paragraph_crop] => Tanshinone IIA contributes to the pathogenesis of endometriosis via renin angiotensin system [...]
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[title] => Melatonin Plus Folic Acid Treatment Ameliorates Reserpine-Induced Fibromyalgia- An Evaluation of Pain- Oxidative Stress- and Inflammation
[paragraph_crop] => Melatonin Plus Folic Acid Treatment Ameliorates Reserpine-Induced Fibromyalgia: An Evaluation [...]
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[url] => https://bioseb.com/fr/news/minocycline-attenuates-the-development-of-diabetic-neuropathy-by-modulating-dream-and-bdnf-protein-expression-in-rat-spinal-cord-n1134
[title] => Minocycline attenuates the development of diabetic neuropathy by modulating DREAM and BDNF protein expression in rat spinal cord
[paragraph_crop] => Minocycline attenuates the development of diabetic neuropathy by modulating DREAM and BDNF [...]
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[title] => IPSE- a parasite-derived host immunomodulatory protein- is a potential therapeutic for hemorrhagic cystitis
[paragraph_crop] => IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for [...]
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[title] => Cholesterol Depletion Regulates Axonal Growth and Enhances Central and Peripheral Nerve Regeneration
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[title] => Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1
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[title] => Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-methyl-D-aspartate Receptors
[paragraph_crop] => Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related [...]
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[title] => May a sigma_1 antagonist improve neuropathic signs induced by cisplatin and vincristine in rats?
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[image_presente] =>
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[title] => Hydrogen-Rich Saline Activated Autophagy via HIF-1_ Pathways in Neuropathic Pain Model
[paragraph_crop] => Hydrogen-Rich Saline Activated Autophagy via HIF-1_ Pathways in Neuropathic Pain Model
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[title] => On the use of Parylene C polymer as substrate for peripheral nerve electrodes
[paragraph_crop] => On the use of Parylene C polymer as substrate for peripheral nerve electrodes
[image_presente] =>
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[title] => Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats
[paragraph_crop] => Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of [...]
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[title] => Role of medullary astroglial glutamine synthesis in tooth pulp hypersensitivity associated with frequent masseter muscle contraction
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[image_presente] =>
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[title] => Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve
[paragraph_crop] => Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and [...]
[image_presente] =>
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[title] => Monoaminergic descending pathways contribute to modulation of neuropathic pain by increasing-intensity treadmill exercise after peripheral nerve injury
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[image_presente] =>
[date] => 2018-01-01 00:00:00
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[url] => https://bioseb.com/fr/news/time-course-study-of-long-term-biocompatibility-and-foreign-body-reaction-to-intraneural-polyimide-based-implants-n942
[title] => Time course study of long-term biocompatibility and foreign body reaction to intraneural polyimide-based implants
[paragraph_crop] => Time course study of long-term biocompatibility and foreign body reaction to intraneural [...]
[image_presente] =>
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[title] => CXCR4 signaling contributes to alveolar bone resorption in Porphyromonas gingivalis-induced periodontitis in mice
[paragraph_crop] => CXCR4 signaling contributes to alveolar bone resorption in Porphyromonas gingivalis-induced [...]
[image_presente] =>
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[title] => Group I metabotropic glutamate receptor plasticity after peripheral inflammation alters nociceptive transmission in the dorsal horn of the spinal cord in adult rats
[paragraph_crop] => Group I metabotropic glutamate receptor plasticity after peripheral inflammation alters [...]
[image_presente] =>
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[url] => https://bioseb.com/fr/news/antinociceptive--antiallodynic-and-antihyperalgesic-effects-of-the-5-ht1a-receptor-selective-agonist--nlx-112-in-mouse-models-of-pain-n898
[title] => Antinociceptive- antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist- NLX-112 in mouse models of pain
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[title] => Maladie de Parkinson
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[url] => https://bioseb.com/fr/news/5ht-in-the-dorsal-raphe-nucleus-is-involved-in-the-effects-of-100hz-electroacupuncture-on-the-paindepression-dyad-in-rats-n1144
[title] => 5_HT in the dorsal raphe nucleus is involved in the effects of 100_Hz electro_acupuncture on the pain_depression dyad in rats
[paragraph_crop] => 5_HT in the dorsal raphe nucleus is involved in the effects of 100_Hz electro_acupuncture on [...]
[image_presente] =>
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[url] => https://bioseb.com/fr/news/cav1--2-and-cav1--3-ltype-calcium-channels-independently-control-shortand-longterm-sensitization-to-pain-n882
[title] => Cav1- 2 and Cav1- 3 l‐type calcium channels independently control short‐and long‐term sensitization to pain
[paragraph_crop] => Cav1. 2 and Cav1. 3 l‐type calcium channels independently control short‐and long‐term sensi [...]
[image_presente] =>
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[url] => https://bioseb.com/fr/news/inhibition-of-the-neuronal-nfb-pathway-attenuates-bortezomib-induced-neuropathy-in-a-mouse-model--n877
[title] => Inhibition of the neuronal NFκB pathway attenuates bortezomib-induced neuropathy in a mouse model-
[paragraph_crop] => Inhibition of the neuronal NFκB pathway attenuates bortezomib-induced neuropathy in a mouse model.
[image_presente] =>
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[url] => https://bioseb.com/fr/news/effect-of-dexmedetomidine-and-cold-stress-in-a-rat-model-of-neuropathic-pain--role-of-interleukin-6-and-tumor-necrosis-factor--n828
[title] => Effect of dexmedetomidine and cold stress in a rat model of neuropathic pain- Role of interleukin-6 and tumor necrosis factor-α
[paragraph_crop] => Effect of dexmedetomidine and cold stress in a rat model of neuropathic pain: Role of [...]
[image_presente] =>
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[title] => In vitro and non?invasive in vivo effects of the cannabinoid?1 receptor agonist AM841 on gastrointestinal motor function in the rat
[paragraph_crop] => In vitro and non?invasive in vivo effects of the cannabinoid?1 receptor agonist AM841 on [...]
[image_presente] =>
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[title] => Maladies auto-immunes
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[url] => https://bioseb.com/fr/news/3-4--3-trifluoromethyl-phenyl--piperazin-1-yl-dihydrofuran-2-one-and-pregabalin-attenuate-tactile-allodynia-in-the-mouse-model-of-chronic-constriction-injury-n775
[title] => 3-[4--3-Trifluoromethyl-phenyl--piperazin-1-yl]-dihydrofuran-2-one and pregabalin attenuate tactile allodynia in the mouse model of chronic constriction injury
[paragraph_crop] => 3-[4--3-Trifluoromethyl-phenyl--piperazin-1-yl]-dihydrofuran-2-one and pregabalin attenuate tactile
[image_presente] =>
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[title] => Early increasing-intensity treadmill exercise reduces neuropathic pain by preventing nociceptor collateral sprouting and disruption of chloride cotransporters homeostasis after peripheral nerve injury
[paragraph_crop] => Early increasing-intensity treadmill exercise reduces neuropathic pain by preventing [...]
[image_presente] =>
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[url] => https://bioseb.com/fr/news/changes-of-voltage-gated-sodium-channels-in-sensory-nerve-regeneration-and-neuropathic-pain-models-n808
[title] => Changes of voltage-gated sodium channels in sensory nerve regeneration and neuropathic pain models
[paragraph_crop] => Changes of voltage-gated sodium channels in sensory nerve regeneration and neuropathic pain models
[image_presente] =>
[date] => 2015-06-17 00:00:00
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[url] => https://bioseb.com/fr/news/inflammatory-pain-memory-facilitates-occlusal-interferenceinduced-masticatory-muscle-hyperalgesia-in-rats-n774
[title] => Inflammatory pain memory facilitates occlusal interference?induced masticatory muscle hyperalgesia in rats
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[image_presente] =>
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[title] => NKCC1 Activation Is Required for Myelinated Sensory Neurons Regeneration through JNK-Dependent Pathway
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[title] => Biocompatibility evaluation of parylene C and polyimide as substrates for peripheral nerve interfaces
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[title] => Antinociceptive activity of transient receptor potential channel TRPV1- TRPA1- and TRPM8 antagonists in neurogenic and neuropathic pain models in mice
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[title] => Effects of Electroacupuncture with Dominant Frequency at SP 6 and ST 36 Based on Meridian Theory on Pain-depression Dyad in Rats
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[title] => A three-dimensional self-opening intraneural peripheral interface -SELINE-
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[url] => https://bioseb.com/fr/news/involvement-of-trpv1-and-trpa1-in-incisional-intraoral-and-extraoral-pain-n658
[title] => Involvement of TRPV1 and TRPA1 in Incisional Intraoral and Extraoral Pain
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[title] => Nociceptive spinal cord neurons of laminae I-III exhibit oxidative stress damage during diabetic neuropathy which is prevented by early antioxidant treatment with epigallocatechin-gallate -EGCG-
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[title] => Tubulization with chitosan guides for the repair of long gap peripheral nerve injury in the rat
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[image_presente] =>
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[title] => BDNF-dependent plasticity induced by peripheral inflammation in the primary sensory and the cingulate cortex triggers cold allodynia and reveals a major role for endogenous BDNF as a tuner of the affective aspect of pain
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[title] => Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin
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[image_presente] =>
[date] => 2014-10-16 00:00:00
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[url] => https://bioseb.com/fr/news/buccal-acetaminophen-provides-fast-analgesia--two-randomized-clinical-trials-in-healthy-volunteers-n697
[title] => Buccal acetaminophen provides fast analgesia- two randomized clinical trials in healthy volunteers
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[image_presente] =>
[date] => 2014-09-26 00:00:00
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[url] => https://bioseb.com/fr/news/monoarthritis-induced-emotional-and-cognitive-impairments-in-rats-are-sensitive-to-low-systemic-doses-or-intra-amygdala-injections-of-morphine-n586
[title] => Monoarthritis-induced emotional and cognitive impairments in rats are sensitive to low systemic doses or intra-amygdala injections of morphine
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[image_presente] =>
[date] => 2014-04-18 00:00:00
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[title] => Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat- Analgesic activity of pregabalin- tramadol and duloxetine
[paragraph_crop] => Face-to-face comparison of the predictive validity of two models of neuropathic pain in the [...]
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[title] => Antiallodynic and antihyperalgesic activity of 3-[4--3-trifluoromethyl-phenyl--piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice
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[title] => Bone marrow mesenchymal stromal cells and olfactory ensheathing cells transplantation after spinal cord injury – a morphological and functional comparison in rats
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[title] => Molecular Mechanisms Underlying the Enhanced Analgesic Effect of Oxycodone Compared to Morphine in Chemotherapy-Induced Neuropathic Pain
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[title] => Assessment of sensory thresholds and nociceptive fiber growth after sciatic nerve injury reveals the differential contribution of collateral reinnervation and nerve regeneration to neuropathic pain
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[url] => https://bioseb.com/fr/news/therapeutic-effects-of-thymoquinone-in-a-model-of-neuropathic-pain--n602
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[date] => 2014-02-01 00:00:00
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[title] => A Polyamine-Deficient Diet Prevents Oxaliplatin-Induced Acute Cold and Mechanical Hypersensitivity in Rats
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[title] => Unexpected association of the “inhibitory” neuroligin 2 with excitatory PSD95 in neuropathic pain
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[title] => Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats
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[title] => Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signalregulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord
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[title] => Hydrogen-rich saline activated autophagy via HIF-1α pathways in neuropathic pain model
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[title] => Validation of the simplified UVB model to assess the pharmacodynamics of analgesics in healthy human volunteers
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[title] => Bidirectional integrative regulation of Cav1-2 calcium channel by microRNA miR-103- role in pain-
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[title] => Biocompatibility of Chronically Implanted Transverse Intrafascicular Multichannel Electrode -TIME- in the Rat Sciatic Nerve-
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[title] => Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat-
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[url] => https://bioseb.com/fr/news/electrical-stimulation-combined-with-exercise-increase-axonal-regeneration-after-peripheral-nerve-injury--n232
[title] => Electrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury-
[paragraph_crop] => Electrical stimulation combined with exercise increase axonal regeneration after peripheral [...]
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[url] => https://bioseb.com/fr/news/nociceptive-responses-and-spinal-plastic-changes-of-afferent-c-fibers-in-three-neuropathic-pain-models-induced-by-sciatic-nerve-injury-in-the-rat--n220
[title] => Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat-
[paragraph_crop] => Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic [...]
[image_presente] =>
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[url] => https://bioseb.com/fr/news/antinociceptive-and-anti-allodynic-effects-of-oral-pl37--a-complete-inhibitor-of-enkephalin-catabolizing-enzymes--in-a-rat-model-of-peripheral-neuropathic-pain-induced-by-vincristine--n192
[title] => Antinociceptive and anti-allodynic effects of oral PL37- a complete inhibitor of enkephalin-catabolizing enzymes- in a rat model of peripheral neuropathic pain induced by vincristine-
[paragraph_crop] => Antinociceptive and anti-allodynic effects of oral PL37, a complete inhibitor of [...]
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[date] => 2008-12-14 00:00:00
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[url] => https://bioseb.com/fr/news/motor-cortex-rtms-in-chronic-neuropathic-pain--pain-relief-is-associated-with-thermal-sensory-perception-improvement--n134
[title] => Motor cortex rTMS in chronic neuropathic pain- pain relief is associated with thermal sensory perception improvement-
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[url] => https://bioseb.com/fr/news/acetaminophen-reinforces-descending-inhibitory-pain-pathways--n167
[title] => Acetaminophen Reinforces Descending Inhibitory Pain Pathways-
[paragraph_crop] => Acetaminophen Reinforces Descending Inhibitory Pain Pathways.
[image_presente] =>
[date] => 2008-07-30 00:00:00
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[url] => https://bioseb.com/fr/news/immediate-electrical-stimulation-enhances-regeneration-and-reinnervation-and-modulates-spinal-plastic-changes-after-sciatic-nerve-injury-and-repair--n159
[title] => Immediate electrical stimulation enhances regeneration and reinnervation and modulates spinal plastic changes after sciatic nerve injury and repair-
[paragraph_crop] => Immediate electrical stimulation enhances regeneration and reinnervation and modulates spinal [...]
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[id] => 1368
[url] => https://bioseb.com/fr/news/cutaneous-amitriptyline-in-human-volunteers--differential-effects-on-the-components-of-sensory-information-n1368
[title] => Cutaneous Amitriptyline in Human Volunteers- Differential Effects on the Components of Sensory Information
[paragraph_crop] => Cutaneous Amitriptyline in Human Volunteers- Differential Effects on the Components of Sensory [...]
[image_presente] =>
[date] => 2008-04-01 00:00:00
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[id] => 76
[url] => https://bioseb.com/fr/news/hyperalgesia-induced-by-cutaneous-freeze-injury-for-testing-analgesics-in-healthy-volunteers--n76
[title] => Hyperalgesia induced by cutaneous freeze injury for testing analgesics in healthy volunteers-
[paragraph_crop] => Hyperalgesia induced by cutaneous freeze injury for testing analgesics in healthy volunteers.
[image_presente] =>
[date] => 2006-04-30 00:00:00
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[url] => https://bioseb.com/fr/news/the-novel-analgesic--f-13640--produces-intra--and-postoperative-analgesia-in-a-rat-model-of-surgical-pain--n58
[title] => The novel analgesic- F 13640- produces intra- and postoperative analgesia in a rat model of surgical pain-
[paragraph_crop] => The novel analgesic, F 13640, produces intra- and postoperative analgesia in a rat model of [...]
[image_presente] =>
[date] => 2005-10-31 00:00:00
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[20] => Array
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[id] => 20
[url] => https://bioseb.com/fr/news/up-regulation-of-fatty-acid-metabolizing-enzymes-mrna-in-rat-spinal-cord-during-persistent-peripheral-local-inflammation--n20
[title] => Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation-
[paragraph_crop] => Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent [...]
[image_presente] =>
[date] => 2003-10-30 00:00:00
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[title] => Douleurs inflammatoires
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[title] => Publications
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[url] => https://bioseb.com/fr/news/large-amplitude-5-ht1a-receptor-activation--a-new-mechanism-of-profound--central-analgesia--n9
[title] => Large-amplitude 5-HT1A receptor activation- a new mechanism of profound- central analgesia-
[paragraph_crop] => Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
[image_presente] =>
[date] => 2002-11-30 00:00:00
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