Ageing-Related Macrophage Polarisation in the Trigeminal Ganglion Enhances Incisional Intraoral Pain

Authors
Kentaro Urata, Tatsuki Oto, Yoshinori Hayashi, Suzuro Hitomi, Takayuki Ikeda, Koichi Iwata, Toshimitsu Iinuma, Masamichi Shinoda


Lab

Journal
Oral Diseases

Abstract
Mechanical head-withdrawal reflex threshold (MHWRT) of the palatal mucosa was measured for 21 days after palatal mucosal incision. On days 3 and 14, the abundance of Iba-1-immunoreactive (IR) cells, CD11c-IR cells (pro-inflammatory macrophages (M1)), C-C motif chemokine ligand 2 (CCL2)-IR M1-macrophages, CD206-IR cells (anti-inflammatory macrophages (M2)) and transforming growth factor-β (TGF-β)-IR M2-macrophages in the TG was analysed. The effect of continuous intra-TG administration of CCL2-neutralising antibody or recombinant-CCL2 on MHWRT was examined.

Keywords/Topics
ageing; CCL2; intraoral mucosa; macrophage; mechanical pain hypersensitivity; trigeminal ganglion

BIOSEB Instruments Used:
Electronic Von Frey - Wireless (BIO-EVF-WRS),Electronic Von Frey 5 with embedded camera (BIO-EVF5)

Source :

https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.15165

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