Subarachnoid-Subarachnoid Bypass Surgery Treats Syringomyelia Through Indirect Drainage via Perivascular Spaces and Ependymal Repair: Evidence from Rat Models and Clinical Application

Authors
Can Zhang, Chenghua Yuan, Jun Bai, Shengyu Cui, Jinze Li, Sumei Liu, Nanding Li, Kang Li, Fan Yuan, Xiaoli Sun, Honglei Liu, Jian Guan, Fengzeng Jian


Lab
Help Center

Journal

Abstract
A modified rat model of syringomyelia was created using polystyrene microspheres to obstruct the SAS. Syrinx volume was assessed by 7.0T MRI, alongside behavioral, electrophysiological, and immunofluorescence analyses comparing subarachnoid–subarachnoid (S-S) bypass with decompression. CSF tracer studies evaluated postoperative dynamics, and confocal imaging quantified tight junction proteins (ZO-1, Claudin-5) and ciliary markers (Arl13b, γ-Tubulin). CSF proteomics explored underlying mechanisms. Clinically, seventeen patients with syringomyelia secondary to arachnoid adhesions underwent S-S bypass as a preliminary feasibility and safety evaluation, with MRI and neurological evaluation pre- and postoperatively.

Keywords/Topics
rat models; postoperative dynamics; thermal sensation; indirect drainage; perivascular spaces; ependymal repair; evidence; clinical application; syringomyelia; polystyrene microspheres

Source :

https://www.researchsquare.com/article/rs-9263061/latest

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