Activité, Système Moteur & Coordination
Douleur - Allodynie/Hyperalgésie Thermique
Douleur - Spontanée - Déficit de Posture
Douleur - Allodynie/Hyperalgésie Mécanique
Anxiété & Dépression
Apprentissage/Mémoire - Attention - Addiction
Physiologie & Recherche Respiratoire
Métabolisme & Prise Alimentaire
Douleur
Système Nerveux Central (SNC) 
Neurodégénérescence
Système sensoriel
Système moteur
Troubles de l'humeur
Autres pathologies
Système musculaire
Articulations
Métabolisme
Thématiques transversales
Congrès & Meetings Authors
K. Ängeby Möller, P. Forsell, G. Nordvall, J. Sandin, C.I. Svensson
Lab
Karolinska Institute, Stockholm, Sweden
Journal
Osteoarthritis and Cartilage
Abstract
Chronic joint pain with pain at walking as major complaint affects a large portion of an aging population. Treatment options for this pain are insufficient, with side effects and less than full efficacy. Lack of predictive power for drug effects has been a major criticism against animal pain models and readouts. Using gait analysis and weight bearing in rats with monoarthritis induced by Freund's complete adjuvant (CFA), we have previously shown effects when interfering with the cyclooxygenase (COX) and nerve growth factor (NGF) pathways, whereas a TRPV1 inhibitor was ineffective.
BIOSEB Instruments Used:
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)
