The Influence of Experimental Hypercalcemia on the Organization of Circadian Rhythms of Rectal Temperature- Some Metabolites and Red Blood Indices

Authors
Areshidze, DA, Kozlova, MA, Kuznetsova, IA, Makartseva, LA

Lab
Moscow State Regional University, Moscow, Russia

Journal
Journal of Pharmaceutical Sciences and Research

Abstract
The results of the study indicate a very significant effect of experimental hypercalcemia on the organization of circadian rhythmicity of the studied metabolites, rectal temperature and red blood indices. The greatest influence of experimental hypercalcemia is manifested in the circadian rhythmicity of albumin, as the animals of the experimental group do not show a reliable rhythm of this substance according to the results of cosinor analysis. The circadian rhythm of blood glucose also undergoes significant changes, and the rhythm of creatinine is the least variable, as does the circadian rhythm of rectal temperature, although in both cases the acrophase of rhythms is shifting. The circadian rhythmicity of the studied blood parameters was also affected by the increased level of Ca in animals. The acrophases of the rhythms of most of the studied hematological parameters in the control group occur at night and early morning hours. In contrast to the control parameters, in the animals of the experimental group the acrophases shift for the light time of day and the beginning of the dark period. Experimental hypercalcemia, in addition to disturbingof circadian rhythmicity as such, leads to desynchronosis of the studied rhythms. Thus, a violation of the normal level of calcium, one of the important homeostatic parameters of an organism, entails significant changes in the circadian rhythms of various body parameters.