Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality

Authors
Y_C Chang, Y_T Chen, H_W Liu, Y_C Chan et al

Lab
Department of Life Sciences, National Cheng Kung University, 701 Tainan, Taiwan

Journal
Molecular Nutrition & Food Research

Abstract
Oligonol has been shown to moderate mitochondrial biogenesis, protein synthesis, and protein degradation in diabetic mice in a previous study. It is therefore hypothesized that oligonol alleviated sarcopenia by regulating pathways involved in protein turnover and mitochondrial quality. Regulating pathways involved in protein synthesis and degradation, mitochondrial biogenesis, mitochondrial fusion/fission, autophagy, and mitochondria_dependent apoptosis by oligonol contribute to positive protein turnover and mitochondrial quality, thus increasing muscle mass and strength in SAMP8 mice.

BIOSEB Instruments Used:
Grip strength test (BIO-GS3)