Perioperative intravenous low_dose ketamine for neuropathic pain after major lower back surgery- A randomized- placebo_controlled study

Authors
C Czarnetzki, J Desmeules, E Tessitore, A Faundez et al


Lab
Division of Anaesthesiology, Department of Anaesthesiology, Intensive Care and Emergency Medicine, Ospedale Regionale di Lugano, Via Tesserete 46, 6900 Lugano, Switzerland.

Journal
European Journal of Pain

Abstract
Chronic pain after major lower back surgery is frequent. We investigated in adults the effect of perioperative low_dose ketamine on neuropathic lower back pain, assessed by the DN4 questionnaire, 6 and 12Êmonths after major lower back surgery. In this single_centre randomized trial, 80 patients received intravenous ketamine 0.25Êmg/kg preoperatively, followed by 0.25ÊmgÊkg_1Êhr_1 intraoperatively, and 0.1ÊmgÊkg_1Êhr_1 from 1Êhr before the end of surgery until the end of recovery room stay; 80 controls received placebo. In this patient population with a high prevalence of neuropathic lower back pain undergoing major lower back surgery, a perioperative intravenous low_dose ketamine infusion did not have an effect on the prevalence of neuropathic lower back pain at 6 or 12Êmonths postoperatively.

BIOSEB Instruments Used:
Electronic Von Frey 4 (BIO-EVF4)

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