Garlic exosome-like nanoparticles reverse high-fat diet induced obesity via the gut/brain axis

Authors
K Sundaram, J Mu, A Kumar et al


Lab
James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA

Journal
Theranostics

Abstract
Obesity is becoming a global epidemic and reversing the pathological processes underlying obesity and metabolic co-morbidities is challenging. Obesity induced chronic inflammation including brain inflammation is a hallmark of obesity via the gut-brain axis. The objective of this study was to develop garlic exosome-like nanoparticles (GaELNs) that inhibit systemic as well as brain inflammatory activity and reverse a HFD induced obesity in mice.

BIOSEB Instruments Used:
Grip strength test (BIO-GS3)

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