Inhibition of SARM1 Reduces Neuropathic Pain in a Spared Nerve Injury Rodent Model

Authors
Christopher G. Herbosa, Ronald Perez, Alexandra Jaeger, Christopher J. Dy, David M. Brogan


Lab

Journal
Muscle & Nerve

Abstract
WT Injury rats were more sensitive to pain than WT Sham at all postoperative time points, validating the pain model. Injured SARM1 KO rats only demonstrated a difference in mechanical or cold nociception from KO Sham at Week 3. Injured KO rats demonstrated a clear trend of decreased sensitivity compared to WT Injury nociception, reaching significance at Week 4 (p= 0.044). Injured KO rats showed attenuated sensitivity to cold allodynia relative to WT at Week 2 (p= 0.019). IHC revealed decreased macrophages in spared sural nerves of injured KO animals at 2 and 4 weeks, and the proximal portion of tibial/peroneal nerves at Week 2.

Keywords/Topics
inflammation; macrophages; nerve injury; neuropathic pain; SARM1

BIOSEB Instruments Used:
Electronic Von Frey - Wireless (BIO-EVF-WRS),Electronic Von Frey 5 with embedded camera (BIO-EVF5)

Source :

https://onlinelibrary.wiley.com/doi/abs/10.1002/mus.28367

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