Behavioral Thermoceptive Responses and Morphologic Correlates in Mouse Models of CMT1A- HNPP- and Aging

Authors
Vaibhav Oberoi, James O. Campbell, Nelson Akpabli-Tsigbe, Fatima Imran, Silvano Bond, Sara Ngo Tenlep, Charles D. Brennan, Meifang Wang, Smita Saxena, Kathryn R. Moss, De-Pei Li, W. David Arnold, Ryan Castoro


Lab

Journal
Journal of the Peripheral Nervous System

Abstract
Thermal gradient testing revealed preserved temperature preference in CMT1A and HNPP mice but significantly altered behavior in aged animals, which spent less time in warmer zones. Hot plate testing showed prolonged times to nocifensive behavior in aged and CMT1A mice, whereas HNPP mice exhibited variable responses. IENFD was markedly reduced in aged mice but preserved in CMT1A and HNPP. DRG analysis revealed smaller soma diameters and reduced proportions of TRPV1-positive Aδ neurons in aged mice, while CMT1A animals maintained normal morphology.

Keywords/Topics
aging; charcot–marie–tooth disease; hereditary neuropathy with liability to pressure palsies; thermoception

BIOSEB Instruments Used:
Cold Hot Plate Test (BIO-CHP),Thermal Gradient Test 2.0 (BIO-GRADIENT2)

Source :

https://onlinelibrary.wiley.com/doi/abs/10.1111/jns.70113

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