Alterations of the endocannabinoid system and circulating and peripheral tissue levels of endocannabinoids in sarcopenic ratscirculating and peripheral tissue levels ofendocannabinoids in sarcopenic rat

Authors
O Le Bacquer, J Salles, F Piscitelli, et al


Lab
INRAE, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne, Clermont-Ferrand, France.

Journal
Journal of Cachexia, Sarcopenia and Muscle

Abstract
Activation of the endocannabinoid system (ECS) is associated with the development of obesity and insulin resistance, and with perturbed skeletal muscle development. Age-related sarcopenia is a progressive and generalized skeletal muscle disorder involving an accelerated loss of muscle mass and function, with changes in skeletal muscle protein homeostasis due to lipid accumulation and anabolic resistance. Hence, both obesity and sarcopenia share a common set of pathophysiological alterations leading to skeletal muscle impairment. The aim of this study was to characterize how sarcopenia impacts the ECS and if these modifications were related to the loss of muscle mass and function associated with aging in rats.

BIOSEB Instruments Used:
Rotarod (BX-ROD),Aron Test or Four Plates Test (LE830)

DEMANDE DE PUBLICATION

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