Activité, Système Moteur & Coordination
Douleur - Allodynie/Hyperalgésie Thermique
Douleur - Spontanée - Déficit de Posture
Douleur - Allodynie/Hyperalgésie Mécanique
Anxiété & Dépression
Apprentissage/Mémoire - Attention - Addiction
Physiologie & Recherche Respiratoire
Métabolisme & Prise Alimentaire
Douleur
Système Nerveux Central (SNC) 
Neurodégénérescence
Système sensoriel
Système moteur
Troubles de l'humeur
Autres pathologies
Système musculaire
Articulations
Métabolisme
Thématiques transversales
Bioseb on booth #14 at OARSI 2024 in Vienna Authors
N. Authier, J.-P. Gillet, J. Fialip, A. Eschalier, F. Coudore.
Lab
Université d’ Auvergne (INSERM EMI 9904), Laboratoire de Toxicologie, Equipe NeuroPsychoPharmacologie, Clermont-Ferrand, France.
Journal
Neurotoxicity Research
Abstract
As the mixture cremophor/ethanol is known to have side-effects affecting the peripheral nervous system, we have assessed its behavioural and morphological neurotoxicity after repeated intraperitoneal injections in male Sprague Dawley rats. Clinical status of the animals was good throughout the experiment and no motor deficits were observed. Nevertheless, sensory testing demonstrated an hyperalgesia and an allodynia to mechanical stimuli, associated to peripheral axon degeneration.
BIOSEB Instruments Used:
Grip strength test (BIO-GS3)
