Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect in mice focusing on the central nervous system

Authors
Zhou, Li, Song, Chenchen, Yang, Hu, Zhao, Lianlian, Li, Xianglei, Sun, Xiuping, Gao, Kai, Guo, Jianguo


Lab

Journal
Scientific Reports

Abstract
A study was conducted to evaluate the three-dimensional clinostat simulated microgravity effect on mouse models, focusing on the central nervous system. Eighteen mice were divided into three groups: control, survival box, and clinostat + survival box. Behavioral tests, femur micro-CT, brain transcriptomics, serum metabolomics, and fecal microbiomics were performed. Results showed decreased activity, altered gait, enhanced fear memory, bone loss, immune/endocrine changes in brain transcriptome, and altered metabolic pathways in serum and gut microbiota in clinostat-treated mice. The model closely mimics spaceflight-induced transcriptome changes, suggesting its value in studying microgravity-related neurological alterations and highlighting the need for attention to emotional changes in space.

Keywords/Topics
Microgravity; Three-dimensional clinostat; Brain; Transcriptomics; Microbiomics; Serum metabolomics; Animal model; Environmental impact; Neuroscience; Physiology; Risk factors; Zoology

BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

Source :

https://www.nature.com/articles/s41598-025-90212-y

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