Autres pathologies - Publications Scientifiques

Dernière publication 19/12/2025

Exosomes derived from platelet-rich plasma alleviate synovial inflammation by en

Synovial inflammation is a pivotal factor in the pathogenesis of osteoarthritis (OA). Platelet-rich plasma-derived Exosomes (PRP-Exos), known for...

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    [title] => Exosomes derived from platelet-rich plasma alleviate synovial inflammation by en
    [paragraph] => Exosomes derived from platelet-rich plasma alleviate synovial inflammation by enhancing synovial lymphatic function
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Authors
Liao, Bo, Tian, Yu, Guan, Mengtong, Han, Wang, Yi, Weiwei, Li, Kaiting, Yang, Xiaoliang, Niu, Yajuan, Zhang, Bin, Teng, Peiyu, Bai, Dingqun, Kuang, Liang, Zhu, Ying, Han, Xiaoyu

 Lab

Journal
Journal of Nanobiotechnology
Abstract
Synovial inflammation is a pivotal factor in the pathogenesis of osteoarthritis (OA). Platelet-rich plasma-derived Exosomes (PRP-Exos), known for their low immunogenicity, have demonstrated efficacy in modulating chondrocyte function. However, the specific effects and mechanisms of PRP-Exos in synovial inflammation remain unclear. This study aimed to investigate the therapeutic effects and mechanisms of PRP-Exos in synovial inflammation induced by destabilization of the medial meniscus (DMM) in mice. PRP-Exos were extracted via ultracentrifugation. In vivo experiments revealed that PRP-Exos alleviated pain behaviors and synovial inflammation in DMM mice. Furthermore, it was discovered that PRP-Exos enhanced the synovial lymphatic function in DMM mice and promoted lymphangiogenesis. Meanwhile, the therapeutic effect of PRP-Exos on synovial inflammation was attenuated after inhibition of lymphatic function. In vitro studies demonstrated that PRP-Exos enhanced the proliferation, migration, and tube formation ability of lymphatic endothelial cells (LECs), via regulating the PI3K/Akt signaling pathway. Conclusions: This research is the first to reveal that PRP-Exos alleviate pain behaviors and synovial inflammation in DMM mice through activation of the PI3K/Akt signaling pathway in LECs, thereby enhancing synovial lymphatic function and promoting the clearance of inflammatory cells and associated cytokines. These findings offer a novel theoretical foundation for the treatment of synovial inflammation and other inflammation-associated disorders.
Keywords/Topics
Platelet-rich plasma-derived exosome; Synovial inflammation; Lymphatic vessel
BIOSEB Instruments Used:
Electronic Von Frey - Wireless (BIO-EVF-WRS),Electronic Von Frey 5 with embedded camera (BIO-EVF5),Static Weight Bearing Touch: Incapacitance Test (BIO-SWB-TOUCH-M)
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Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

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L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

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