Mouse Models for Studying Depression-Like States and Antidepressant Drugs

Authors
Bergner CL, Smolinsky AN, Hart PC, Dufour BD, Egan RJ, Laporte JL, Kalueff AV.


Lab
Department of Physiology, Georgetown University Medical School, Washington, DC, USA.

Journal
Methods Mol Biol.

Abstract
Depression is a common psychiatric disorder, with diverse symptoms and high comorbidity with other brain dysfunctions. Due to this complexity, little is known about the neural and genetic mechanisms involved in depression pathogenesis. In a large proportion of patients, current antidepressant treatments are often ineffective and/or have undesirable side effects, fueling the search for more effective drugs. Animal models mimicking various symptoms of depression are indispensable in studying the biological mechanisms of this disease. Here, we summarize several popular methods for assessing depression-like symptoms in mice and their utility in screening antidepressant drugs.

BIOSEB Instruments Used
Smart 3.0 - Video Tracking System (SMART30)

Source :

http://www.ncbi.nlm.nih.gov/pubmed/20012404

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