Transcranial direct current stimulation enhances recovery from motor deficits following hypoxia-ischemia in neonatal rats

Authors
C. L. Anderson, B. J. Tessler , T. B. DeMarse, M. Douglas-Escobar, C. Rossignol, R. Nelson, A. K. Kasinadhuni, M. King, P. Bose, M. D. Weiss, P. R. Carney


Lab
University of Florida, Crayton Pruitt Family Department of Biomedical Engineering, , Gainesville, Florida

Journal
Opne Access Text

Abstract
Prenatal cerebrovascular stroke can cause permanent damage to the brain followed by deficits in neuro-muscular functioning. We hypothesize that recovery can be enhanced by transcranial direct current stimulation (tDCS) through changes in cortical plasticity. Unilateral hypoxia-ischemia (HI) was produced in rats on postnatal day 7 (P7). At P21, anodal tDCS was given to HI pups for 7 days. tDCS treated HI pups showed improved weight, grip strength, gait, motor function, and concentrations of brain-derived neurotropic factor cortex ratios compared to non-treated HI animal controls. These findings support tDCS following HI as an effective therapeutic for neonatal stroke.

BIOSEB Instruments Used:
Grip strength test (BIO-GS3)

Produits associés

Test d'agrippement

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