Increased peritoneal B1-like cells during acute phase of human septic peritonitis

Authors
Christian von Loeffelholz, Ren Winkler, Cynthia Weigel, Eva-Maria Piskor, Wolfgang Vivas, Falk Rauchfuss, Utz Settmacher, Ignacio Rubio, Sebastian Weis, Markus H. Grler, Michael Bauer, Christian Kosan


Lab

Journal
iScience

Abstract

Summary

Sepsis is a life-threatening condition caused by dysregulated host responses to infection. Myeloid cell accumulation and lymphocyte decline are widely recognized phenomena in septic patients. However, the fate of specific immune cells remains unclear. Here, we report the results of a human explorative study of patients with septic peritonitis and patients undergoing abdominal surgery without sepsis. We analyzed pairwise peritoneal fluid and peripheral blood taken 24h after surgery to characterize immediate immune cell changes. Our results show that myeloid cell expansion and lymphocyte loss occur in all patients undergoing open abdominal surgery, indicating that these changes are not specific to sepsis. However, B1-like lymphocytes were specifically increased in the peritoneal fluid of septic patients, correlating positively with sequential organ failure assessment (SOFA) and acute physiology and chronic health evaluation II (APACHE-II) clinical severity scores. In support of this notion, we identified an accumulation of peritoneal B1b lymphocytes in septic mice.

Keywords/Topics
increased;peritoneal;cells;during;acute;phase;human;septic;peritonitis;summary

Source :

https://www.cell.com/iscience/fulltext/S2589-0042(24)01358-0

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