Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-ß signaling in mice

Authors
RD Chavez, P Sohn, R Serra


Lab
Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Alabama, United States of America

Journal
PLOS One

Abstract
Objective Prg4, also known as Lubricin, acts as a joint/boundary lubricant. Prg4 has been used to prevent surgically induced osteoarthritis (OA) in mice. Surgically induced OA serves as a good model for post-traumatic OA but is not ideal for recapitulating age-related OA. Reduced expression of the TGF-_ type II receptor (TGF_R2) is associated with age-related OA in clinical samples, so we previously characterized a mouse model that exhibits OA due to expression of a mutated dominant-negative form of TGF_R2 (DNIIR). Prg4 expression was significantly reduced in DNIIR mice. Furthermore, we showed that Prg4 was a transcriptional target of TGF-

BIOSEB Instruments Used:
Automatic Foot misplacement apparatus (BIO-FMA)

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