Fonction cardiaque - page 2 - Publications Scientifiques

Dernière publication 30/10/2018

May a sigma_1 antagonist improve neuropathic signs induced by cisplatin and vinc

Rats treated with antitumourals developed tactile allodynia, while those treated with vincristine also developed mechanical hyperalgesia. These in...

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    [title] => May a sigma_1 antagonist improve neuropathic signs induced by cisplatin and vinc
    [paragraph] => May a sigma_1 antagonist improve neuropathic signs induced by cisplatin and vincristine in rats?
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Authors
N Paniagua, C Goicoechea, R Abalo

 Lab
Universidad Rey Juan Carlos, Alcorcón, Spain.
Journal
European Journal of Pain
Abstract
Rats treated with antitumourals developed tactile allodynia, while those treated with vincristine also developed mechanical hyperalgesia. These in vivo modifications correlated with electrophysiological hyperactivity (increased spontaneous activity and hyperresponsiveness to innocuous and noxious mechanical stimulation). Animals treated with cisplatin showed gastrointestinal impairment and those receiving vincristine showed cardiovascular toxicity. A single dose of MR_309 strongly reduced both nociceptive behaviour and electrophysiological changes. Moreover, its concomitant administration with the antitumourals blocked the development of neuropathic symptoms, thus restoring mechanical sensitivity, improving the impairment of feeding behaviour and gastrointestinal transit in the cisplatin_treated group along with ameliorating the altered vascular reactivity recorded in rats treated with vincristine.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

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L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

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