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Dernière publication 29/06/2018

Anti-inflammatory effects of Metformin improve the neuropathic pain and locomoto

Metformin is a safe drug for controlling blood sugar in diabetes. It has been shown that metformin improves locomotor recovery after spinal cord...

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    [date] => 2018-06-29 00:00:00
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    [title] => Anti-inflammatory effects of Metformin improve the neuropathic pain and locomoto
    [paragraph] => Anti-inflammatory effects of Metformin improve the neuropathic pain and locomotor activity in spinal cord injured rats: introduction of an alternative therapy
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Authors
K Afshari, A Dehdashtian, N-S Haddadi, A Haj-Mirzaian, A Iranmehr, M Ali Ebrahimi, SM Tavangar, H Faghir-Ghanesefat, F Mohammadi, N Rahimi, AN Javidan, A R Dehpou



 Lab
Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran


Journal
Spinal Chord


Abstract
Metformin is a safe drug for controlling blood sugar in diabetes. It has been shown that metformin improves locomotor recovery after spinal cord injury (SCI). Neuropathic pain is also a disturbing component of SCI. It is indicated that metformin has neuroprotective and anti-inflammatory effects, which attenuate neuropathic pain and hyperalgesia in injured nerves. Thus, we evaluated metformin’s therapeutic effects on SCI neuroinflammation and its sensory and locomotor complications. Meanwhile, results were compared to minocycline, an anti-neuroinflammation therapy in SCI.
BIOSEB Instruments Used
Von Frey Filaments (Bio-VF-M)

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Jeu de 20 filaments basé sur le jeu de monofilaments de Wemmes Weinstein - filament rétractable pour protéger celui-ci et faciliter le transport


Instrument for ratsInstrument for mice

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