Publications

Dernière publication 29/05/2022

Conservative analysis of Synaptopodin-2 intron sense-overlapping lncRNA reveals

Dissection of the regulatory pathways that control skeletal muscle development and atrophy is important for the treatment of muscle wasting. Long...

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    [title] => Conservative analysis of Synaptopodin-2 intron sense-overlapping lncRNA reveals 
    [paragraph] => Conservative analysis of Synaptopodin-2 intron sense-overlapping lncRNA reveals its novel function inpromoting muscle atrophy
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Authors
J Jin, M Du, J Wang, Y Guo et al

 Lab
Huazhong Agricultural University, Wuhan, China
Journal
Journal of Cachexia, Sarcopenia and Muscle
Abstract
Dissection of the regulatory pathways that control skeletal muscle development and atrophy is important for the treatment of muscle wasting. Long noncoding RNA (lncRNA) play important roles in various stages of muscle development. We previously reported that Synaptopodin-2 (SYNPO2) intron sense-overlapping lncRNA (SYISL) regu lates myogenesis through an interaction with enhancer of zeste homologue 2 (EZH2). However, it remains unclear whether SYISL homologues exist in humans and pigs, and whether the functions and mechanisms of these homologues are conserved among species.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
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