Douleurs neuropathiques - page 11 - Publications Scientifiques

Dernière publication 01/02/2011

Longitudinal study of wind-up responses after graded spinal cord injuries in the

PURPOSE: The main objectives of this work were to evaluate the development of neuropathic pain after spinal cord injuries of different severities,...

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    [title] => Longitudinal study of wind-up responses after graded spinal cord injuries in the
    [paragraph] => Longitudinal study of wind-up responses after graded spinal cord injuries in the adult rat. 
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Authors
E. Redondo Castro, E. Udina, E. Verdú, X. Navarro. 

 Lab
 Institute of Neurosciences and Department of Cell Biology, Group of Neuroplasticity and Regeneration, Bellaterra, Spain.
Journal
Restorative neurology and Neuroscience
Abstract
PURPOSE: The main objectives of this work were to evaluate the development of neuropathic pain after spinal cord injuries of different severities, and to assess changes in central excitability and plasticity by means of wind-up responses and withdrawal reflexes. METHODS: Two groups of rats were subjected to spinal cord contusion with forces of 100 or 200 kdyn applied at T8. Measurements of thermal and mechanical pain thresholds as well as wind-up measurements were performed weekly during two months after injury. Withdrawal reflexes were also assessed electrophysiologically. RESULTS: We found that animals with contusion of different severities showed a similar reduction in nociceptive thresholds. All contused animals showed increased wind-up responses compared to intact animals during the first 2 to 6 weeks post injury. The mean increase of wind-up was higher in rats with stronger spinal cord contusion. Results from the withdrawal reflexes did not correlate with nociceptive behaviors nor wind-up responses, highlighting the plasticity of spinal circuits modulation after SCI. CONCLUSION: These results indicate that the graded-force spinal cord contusion model is suitable for studying central neuropathic pain, and for assessing changes in wind-up responses. Wind-up measurements can be used as a non-invasive technique to detect changes in central excitability after SCI of different severities.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

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L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

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