Régénération nerveuse - page 3 - Publications Scientifiques

Dernière publication 08/04/2011

Passive and active exercise improve regeneration and muscle reinnervation after

INTRODUCTION: Lesions of peripheral nerves cause loss of motor and sensory function and also lead to hyperreflexia and hyperalgesia....

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    [paragraph] => Passive and active exercise improve regeneration and muscle reinnervation after peripheral nerve injury in the rat. 
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Authors
E. Udina, A. Puigdemasa, X. Navarro.


Lab
Universitat Autònoma de Barcelona, Institute of Neurosciences and Department of Cell Biology, Group of Neuroplasticity and Regeneration, Bellaterra, Spain.

Journal
Muscle and Nerve

Abstract
INTRODUCTION: Lesions of peripheral nerves cause loss of motor and sensory function and also lead to hyperreflexia and hyperalgesia. Activity-dependent therapies promote axonal regeneration and functional recovery and may improve sensory-motor coordination and restoration of adequate circuitry at the spinal level. METHODS: We compared the effects of passive (bicycle) and active (treadmill) exercise on nerve regeneration and modulation of the spinal H reflex after transection and repair of the rat sciatic nerve. Animals were evaluated during 2 months using electrophysiological, functional, and histological methods. RESULTS: Moderate exercise for 1 hour/day, either active treadmill walking or passive cycling, improved muscle reinnervation, increased the number of regenerated axons in the distal nerve, and reduced the increased excitability of spinal reflexes after nerve lesion. DISCUSSION: Maintenance of denervated muscle activity and afferent input, by active or passive exercise, may increase trophic factor release to act on regenerating axons and to modulate central neuronal plasticity.

BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)

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Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

Instrument for ratsInstrument for mice

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En tant que version électronique du classique esthésiomètre à filaments de Von Frey, la dernière évolution de l’instrument électronique Von Frey de Bioseb, conçu pour déterminer le seuil de sensibilité mécanique chez les rongeurs (rats et souris) par stimulation sous la patte, est un outil indispensable pour vos recherches sur l’hyperalgésie et l’allodynie. En mesurant et en enregistrant la force à laquelle l’animal présente un réflexe de retrait de la patte, il est possible d’étudier les pathologies liées à la réponse sensorielle ainsi qu’à l’hyper- ou l’hypoesthésie.

L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

Instrument for ratsInstrument for mice

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