Publications

Dernière publication 01/06/2025

Extensive Periosteal Injury During Fracture Induces Long-Term Pain in Mice

Bone fractures pose a significant public health challenge, often necessitating surgical interventions to facilitate bone healing and functional...

Array
(
    [id_prestablog_news] => 2008
    [id_shop] => 1
    [date] => 2025-06-01 00:00:00
    [date_modification] => 2025-06-01 00:00:00
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 3946
    [id_lang] => 2
    [title] => Extensive Periosteal Injury During Fracture Induces Long-Term Pain in Mice
    [paragraph] => Extensive Periosteal Injury During Fracture Induces Long-Term Pain in Mice
    [content] => 
Authors
Jiaoni Li, Yu-Ru Vernon Shih, Huchen Tao, Mitchell Negus, Jeffrey Bohrer Guerra, Shyni Varghese

 Lab

Journal
Journal of Orthopaedic Research®
Abstract
Bone fractures pose a significant public health challenge, often necessitating surgical interventions to facilitate bone healing and functional recovery. Sensory nerve fibers innervate various compartments of the bone tissue, with the periosteum exhibiting the most extensive innervation that is susceptible to injury during trauma. Despite its importance, the effect of injured periosteum on fracture pain remains unknown. This study examines the impact of extensive periosteal injury on fracture pain by using a mouse model. Periosteal injury is induced by mechanical resection during unilateral transverse fracture and compared to transverse fractures with no periosteal injury. Our results demonstrate that extensive periosteal injury induces severe and long-term pain, as assessed by von Frey and BIO-DWB-DUAL measurements, for up to 12 weeks postfracture. Immunofluorescence staining revealed an increase in local neurofilament heavy polypeptide (NF200 +) nerve innervation and an elevated number of calcitonin gene-related peptide (CGRP +) expressing neurons in the dorsal root ganglion (DRG). Additionally, flow cytometric analyses revealed increased presence of myeloid immune cells in the DRG. Furthermore, bone healing in fractures with extensive periosteal injury exhibited reduced callus size at all time points as assessed by Faxitron X-ray imaging. This study describes a previously unknown effect of extensive periosteal injury in exacerbating fracture pain and establishes a potential model to study long-term orthopedic fracture pain.
Keywords/Topics
bone; fracture; pain; periosteum; trauma
BIOSEB Instruments Used:
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)
    [meta_description] => 
    [meta_keywords] => https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.26067
    [meta_title] => 
    [link_rewrite] => Extensive-Periosteal-Injury-During-Fracture-Induces-Long-Term-Pain-in-Mice
    [actif_langue] => 1
    [read] => 1
    [count_comments] => 0
    [id] => 2008
    [categories] => Array
        (
            [75] => Array
                (
                    [id_prestablog_categorie] => 75
                    [title] => Fractures
                    [link_rewrite] => Fractures
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Extensive Periosteal Injury During Fracture Induces Long-Term Pain in Mice
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1216] => Array
                (
                    [name] => Distribution Pondérale Dynamique 2.0
                    [description_short] => 
Un système permettant l'analyse de la posture des animaux par la répartition du poids sur chacune des 4 pattes. Le DWB est un test unique dans l'étude de nombreux modèles de douleurs, principalement non évoquée , neuropathique ou encore inflammatoire ainsi que pour les études sur l'osthéoarthrite et divers affections du SNC. 

Le nouvelle version DWB2 intègre une nouvelle interface logiciel plus simple avec gestion des listes d'animaux ainsi que de nouveaux algorithmes d'analyse automatique de la posture.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-spontanee-deficit-de-posture/1216-dynamic-weight-bearing-20.html
                )

        )

)
1