Publications

Dernière publication 27/11/2021

Alverine citrate promotes myogenic differentiation and ameliorates muscle atroph

Sarcopenia is the age-related loss of muscle mass and function and no pharmacological medication has been approved for its treatment. We...

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    [date] => 2021-11-27 00:00:00
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    [title] => Alverine citrate promotes myogenic differentiation and ameliorates muscle atroph
    [paragraph] => Alverine citrate promotes myogenic differentiation and ameliorates muscle atrophy
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Authors
JH Yoon, SM Lee, Y Lee et al

 Lab
Aging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 1Yuseong-gu, Daejeon, Republic of Korea.
Journal
Biochemical and Biophysical Research Communications
Abstract
Sarcopenia is the age-related loss of muscle mass and function and no pharmacological medication has been approved for its treatment. We established an atrogin-1/MAFbx promoter assay to find drug candidates that inhibit myotube atrophy. Alverine citrate (AC) was identified using high-throughput screening of an existing drug library. AC is an established medicine for stomach and intestinal spasms. AC treatment increased myotube diameter and inhibited atrophy signals induced by either C26-conditioned medium or dexamethasone in cultured C2C12 myoblasts. AC also enhanced myoblast fusion through the upregulation of fusion-related genes during C2C12 myoblast differentiation. Oral administration of AC improves muscle mass and physical performance in aged mice, as well as hindlimb-disused mice. Taken together, our data suggest that AC may be a novel therapeutic candidate for improving muscle weakness, including sarcopenia.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Atrophie musculaire
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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