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Dernière publication 11/10/2012

Stress-induced increase in skeletal muscle force requires PKA phosphorylation of

Enhancement of contractile force (inotropy) occurs in skeletal muscle following neuro-endocrine release of catecholamines and activation of muscle...

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    [title] => Stress-induced increase in skeletal muscle force requires PKA phosphorylation of
    [paragraph] => Stress-induced increase in skeletal muscle force requires PKA phosphorylation of the ryanodine receptor
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Authors
Daniel C. Andersson, Matthew J. Betzenhauser, Steven Reiken, Alisa Umanskaya, Takayuki Shiomi, Andrew R. Marks

 Lab
College of Physicians and Surgeons of Columbia University, New York, USA
Journal
The Journal of Physiology
Abstract
Enhancement of contractile force (inotropy) occurs in skeletal muscle following neuro-endocrine release of catecholamines and activation of muscle ?-adrenergic receptors. Despite extensive study, the molecular mechanism underlying the inotropic response in skeletal muscle is not well understood. Here we show that phosphorylation of a single serine residue (S2844) in the sarcoplasmic reticulum (SR) Ca2+ release channel/ryanodine receptor type 1 (RyR1) by cAMP-dependent protein kinase A (PKA) is critical for skeletal muscle inotropy. Treating fast-twitch skeletal muscle from wild type mice with the ?-receptor agonist isoproterenol (ISO) increased RyR1 PKA phosphorylation, twitch Ca2+ and force generation. In contrast, the enhanced muscle Ca2+, force and in vivo muscle strength responses following ISO stimulation were abrogated in RyR1-S2844A mice in which the Serine in the PKA site in RyR1 was replaced with alanine. These data suggest that the molecular mechanism underlying skeletal muscle inotropy requires enhanced SR Ca2+ release due to PKA phosphorylation of Serine 2844 in RyR1.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
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