Douleurs neuropathiques - page 11 - Publications Scientifiques

Dernière publication 15/12/2005

Assessment of nociception in acrylamide-induced neuropathy in rats-

Acrylamide was intraperitoneally administered to male Sprague-Dawley rats at four different doses (5, 10, 20 and 30 mg/kg) three times a week for 5...

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    [title] => Assessment of nociception in acrylamide-induced neuropathy in rats-
    [paragraph] => Assessment of nociception in acrylamide-induced neuropathy in rats.
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Authors
B. Ling, N. Authier, D. Balayssac, A. Eschalier, F. Coudore.

 Lab
Laboratoire de Pharmacologie-Toxicologie, CHU Gabriel-Montpied, Clermont-Ferrand, France.
Journal
Pain
Abstract
Acrylamide was intraperitoneally administered to male Sprague-Dawley rats at four different doses (5, 10, 20 and 30 mg/kg) three times a week for 5 consecutive weeks. Because of motor dysfunction, the 30 mg/kg dose was not used for behavioral pain tests. Clinical status remained good throughout the experiment and no motor deficit was observed at the other doses. We showed that acrylamide administration at low doses and cumulative dose (CD) range of 35–140 mg/kg produced mechanical allodynia and rapid, marked heat (42 °C) and cold (10 °C) allodynia after tail immersion test. Mechanical and thermal hyperalgesia appeared after higher cumulative doses (70–280 mg/kg), except for cold (4 °C) hyperalgesia (20–80 mg/kg). All the modifications persisted throughout all study, except the mechanical hyperalgia. All the cumulative doses tested were lower than those generally reported to induce motor dysfunction (CD>250 mg/kg), confirming that CD may be considered to be a suitable index in assessing neurological signs and suggesting that early detection of acrylamide neurotoxicity would be possible using the sensory tests, especially those for detecting allodynia thresholds.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Douleurs neuropathiques; Douleur
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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