Publications

Dernière publication 28/02/2005

CB1 Receptor Knockout Mice Display Reduced Ethanol-Induced Conditioned Place Pre

Cannabinoids and ethanol activate the same reward pathways, and recent advances in the understanding of the neurobiological basis of alcoholism...

Array
(
    [id_prestablog_news] => 41
    [id_shop] => 1
    [date] => 2005-02-28 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 82
    [id_lang] => 2
    [title] => CB1 Receptor Knockout Mice Display Reduced Ethanol-Induced Conditioned Place Pre
    [paragraph] => CB1 Receptor Knockout Mice Display Reduced Ethanol-Induced Conditioned Place Preference and Increased Striatal Dopamine D2 Receptors.
    [content] => 
Authors
H. Houchi, D. Babovic, O. Pierrefiche, C. Ledent, M. Daoust et al.

 Lab
Université de Picardie Jules Verne, Groupe de Recherche sur l’Alcool et les Pharmacodépendances (GRAP), Amiens, France.
Journal
Neuropsychopharmacology
Abstract
Cannabinoids and ethanol activate the same reward pathways, and recent advances in the understanding of the neurobiological basis of alcoholism suggest that the CB1 receptor system may play a key role in the reinforcing effects of ethanol and in modulating ethanol intake. In the present study, male CB1 receptors knockout mice generated on a CD1 background displayed decreased ethanol-induced conditioned place preference (CPP) compared to wild-type (CB1_/_) mice. Ethanol (0.5, 1.0, 1.5, and 2.0 g/kg) induced significant CPP in CB1_/_ mice at all doses tested, whereas it induced significant CPP only at the highest dose of ethanol (2.0 g/kg) in CB1 /  mice. However, there was no genotypic difference in cocaine (20 mg/kg)-induced CPP. There was also no genotypic difference, neither in cocaine (10–50 mg/kg) nor in D-amphetamine (1.2–5 mg/kg)-induced locomotor effects. In addition, mutant and wild-type mice did not differ in sensitivity to the anxiolytic effects of ethanol (1.5 g/kg) when tested using the elevated plus maze. Interestingly, this decrease in ethanol efficacy to induce CPP in CB1 /  mice was correlated with an increase in D2/D3 receptors, as determined by [3H]raclopride binding, whereas there was no difference in D1-like receptors, as determined by [3H]SCH23390 binding, measured in the striatum from drug-na?¨ve mice. This increase in D2/D3 binding sites observed in CB1 knockout mice was associated with an altered locomotor response to the D2/D3 agonist quinpirole (low doses 0.02–0.1 mg/kg) but not to an alteration of quinpirole (0.1–1.0 mg/kg)-induced CPP compared to wild-type mice. Altogether, the present results indicate that lifelong deletion of CB1 receptors reduced ethanol-induced CPP and that these reduced rewarding effects of ethanol are correlated to an overexpression of striatal dopamine D2 receptors.
BIOSEB Instruments Used
Place Preference Cage (BX-CPP),Spatial place preference Test (BX-SPP)
    [meta_description] => 
    [meta_keywords] => http://www.nature.com/npp/journal/v30/n2/pdf/1300568a.pdf
    [meta_title] => 
    [link_rewrite] => cb1-receptor-knockout-mice-display-reduced-ethanol-induced-conditioned-place-preference-and-increased-striatal-dopamine-d2-receptors-
    [actif_langue] => 1
    [read] => 871
    [count_comments] => 0
    [id] => 41
    [categories] => Array
        (
            [26] => Array
                (
                    [id_prestablog_categorie] => 26
                    [title] => Domaines de recherche divers
                    [link_rewrite] => Domaines-de-recherche-divers
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => CB1 Receptor Knockout Mice Display Reduced Ethanol-Induced Conditioned Place Preference and [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [10] => Array
                (
                    [name] => Cage de préférence de place
                    [description_short] => 
Une chambre expérimentale standard pour l'évaluation automatisée ou manuelle de la préférence de place conditionnée et de l'aversion chez les rongeurs (rats ou souris), deux tests largement utilisés pour le criblage des effets appétitifs de médicaments ou de stimuli naturels, ainsi que les systèmes neuro-biologiques du cerveau impliqués dans les mécanismes de récompense et d'addiction.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/apprentissagememoire-attention-addiction/10-place-preference-cage.html
                )

            [43] => Array
                (
                    [name] => Test de préférence de place spatiale
                    [description_short] => 
Une chambre expérimentale développée dans le but d'optimiser la préférence de place et les études d'aversion chez le petit animal de laboratoire, et en particulier la souris, en incluant une innovation exclusive: la possibilité de combiner une nouvelle dimension spatiale afin d'autoriser l'animal à différencier les différents compartiments d'une manière plus discriminante.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/apprentissagememoire-attention-addiction/43-spatial-place-preference-test.html
                )

        )

)
1