Douleurs neuropathiques - page 3 - Publications Scientifiques

Dernière publication 24/02/2022

A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueduc

The hypothalamic neuropeptide, oxytocin (OT), exerts prominent analgesic effects via central and peripheral action. Here we discovered a novel...

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    [title] => A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueduc
    [paragraph] => A novel analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray
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Authors
M Iwasaki, A Lefevre, F Althammer et al

 Lab
Centre National de la Recherche Scientifique and University of Strasbourg, Institute of Cellular and Integrative Neuroscience, Strasbourg, France
Journal
bioRxiv
Abstract
The hypothalamic neuropeptide, oxytocin (OT), exerts prominent analgesic effects via central and peripheral action. Here we discovered a novel subset of OT neurons whose projections preferentially terminate on OT receptor (OTR)-expressing neurons in the ventrolateral periaqueductal gray (vlPAG). Using a newly generated line of transgenic rats (OTR-IRES-Cre), we determined that most of the vlPAG OTR expressing cells being targeted by OT projections are GABAergic in nature. Both optogenetically-evoked axonal OT release in the vlPAG as well as chemogenetic activation of OTR vlPAG neurons results in a long-lasting overall increase of vlPAG neuronal activity. This then leads to an indirect suppression of sensory neuron activity in the spinal cord and strong analgesia. Finally, we describe a novel OT_vlPAG_spinal cord circuit that seems critical for analgesia in the context of both inflammatory and neuropathic pain.
BIOSEB Instruments Used
Rodent pincher - analgesia meter (BIO-RP-M)
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Un algomètre rapide et précis, basé sur une pince instrumentée: une alternative au test de Randall-Selitto. Ce nouvel algésimètre développé par Bioseb selon Luis-Delgado et al. (2005) permet des tests nociceptifs précis et la mesure du seuil de douleur mécanique sur pattes de rats ou de souris, avec une contrainte minimale. Maintenant en version sans-fil, pour être libéré des câbles!

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