Douleurs neuropathiques - page 3 - Publications Scientifiques

Dernière publication 06/03/2021

The Roles of Superoxide on At-Level Spinal Cord Injury Pain in Rat

: Background: In the present study, we examined superoxide-mediated excitatory nociceptive transmission on at-level neuropathic pain following...

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    [title] => The Roles of Superoxide on At-Level Spinal Cord Injury Pain in Rat 
    [paragraph] => The Roles of Superoxide on At-Level Spinal Cord Injury Pain in Rat 
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Authors
BH Lee, J Kang, HY Kim et al

 Lab
Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea
Journal
International Journal of Molecular Sciences
Abstract
Abstract: Background: In the present study, we examined superoxide-mediated excitatory nociceptive transmission on at-level neuropathic pain following spinal thoracic 10 contusion injury (SCI) in male Sprague Dawley rats. Methods: Mechanical sensitivity at body trunk, neuronal firing activity, and expression of superoxide marker/ionotropic glutamate receptors (iGluRs)/CamKII were mea sured in the T7/8 dorsal horn, respectively. Results: Topical treatment of superoxide donor t-BOOH (0.4 mg/kg) increased neuronal firing rates and pCamKII expression in the naïve group, whereas superoxide scavenger Tempol (1 mg/kg) and non-specific ROS scavenger PBN (3 mg/kg) decreased firing rates in the SCI group (* p < 0.05). SCI showed increases of iGluRs-mediated neuronal firing rates and pCamKII expression (* p < 0.05); however, t-BOOH treatment did not show significant changes in the naïve group. The mechanical sensitivity at the body trunk in the SCI group (6.2 ± 0.5) was attenuated by CamKII inhibitor KN-93 (50 microg, 3.9 ± 0.4) or Tempol (1 mg, 4 ± 0.4) treatment (* p < 0.05). In addition, the level of superoxide marker Dhet showed significant increase in SCI rats compared to the sham group (11.7 ± 1.7 vs. 6.6 ± 1.5, * p < 0.05). Conclusions: Superoxide and the pCamKII pathway contribute to chronic at-level neuropathic pain without involvement of iGluRs following SCI. 
BIOSEB Instruments Used
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Keywords/Topics
Douleurs neuropathiques
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