Allodynie mécanique & Hyperalgésie - page 2 - Publications Scientifiques

Dernière publication 14/03/2020

GABAergic modulation of secondary hyperalgesia- A randomized controlled 4_way cr

The antihyperalgesic and sedative effects of the _2_subunit preferring GABAA positive allosteric modulator (GAM), N_desmethyl_clobazam (NDMC), 20...

Array
(
    [id_prestablog_news] => 1247
    [id_shop] => 1
    [date] => 2020-03-14 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2452
    [id_lang] => 2
    [title] => GABAergic modulation of secondary hyperalgesia- A randomized controlled 4_way cr
    [paragraph] => GABAergic modulation of secondary hyperalgesia: A randomized controlled 4_way crossover trial with the alpha2_subunit preferring GABA positive allosteric modulator, N_desmethyl_clobazam in healthy volunteers 
    [content] => 
Authors
A Matthey, Y Daali, F Curtin, et al

 Lab
Division of Clinical Pharmacology and Toxicology, University Hospital of Geneva, Geneva, Switzerland.
Journal
European Journal of Pain
Abstract
The antihyperalgesic and sedative effects of the _2_subunit preferring GABAA positive allosteric modulator (GAM), N_desmethyl_clobazam (NDMC), 20 and 60 mg, were assessed in a randomized, placebo and active_controlled (clonazepam 1,5 mg), 4_way crossover study, in healthy volunteers, using the ultraviolet B_induced experimental pain model. Single (20, 40, 60 mg) and repeated doses (20 mg over 15 days) of NDMC pharmacokinetics were evaluated. Thirty_two subjects participated in the study. Primary outcome parameter was maximal change in the area of cutaneous UVB irradiation_induced secondary hyperalgesia (ASH). ASH decreased under all treatments. Mean (SD) relative change was 79 (22)%, 83 (24)%, 77 (30)% and 92 (16)% for placebo, NDMC20, NDMC60 and clonazepam, respectively. Neither absolute change nor relative change in ASH was significantly different between NDMC60 and placebo (mean difference = 2.3 cm2 [95% CI 4.0–8.5], p = .462 and 0.4% [_11.9 to 12.6], p = .952, respectively). An overall treatment effect was found on level of sedation. Compared to placebo, sedation was higher under clonazepam (mean difference = 39 mm [30–49] on a visual analogue scale, p < .001) while NDMC was free of sedative effect. NDMC pharmacokinetics after single doses showed poor absorption, but was linear. Steady_state plasma concentrations of NDMC20 were attained within 14 days, with low between_subjects variability. Mean steady_state concentration (CS_S, SD) reached 209 (22) ng/ml. NDMC absence of sedative effect and its overall well_characterized safety coming from years of utilization as a metabolite from clobazam, raise the prospect of dose escalating trials in patients to quantify its clinical utility.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
    [meta_description] => 
    [meta_keywords] => https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.1554
    [meta_title] => 
    [link_rewrite] => gabaergic-modulation-of-secondary-hyperalgesia--a-randomized-controlled-4way-crossover-trial-with-the-alpha2subunit-preferring-gaba-positive-allosteric-modulator--ndesmethylclobazam-in-healthy-volunteers-
    [actif_langue] => 1
    [read] => 1225
    [count_comments] => 0
    [id] => 1247
    [categories] => Array
        (
            [36] => Array
                (
                    [id_prestablog_categorie] => 36
                    [title] => Allodynie mécanique & Hyperalgésie
                    [link_rewrite] => Allodynie-mecanique-Hyperalgesie
                )

            [10] => Array
                (
                    [id_prestablog_categorie] => 10
                    [title] => Douleur
                    [link_rewrite] => Douleur
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => GABAergic modulation of secondary hyperalgesia: A randomized controlled 4_way crossover trial [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1859] => Array
                (
                    [name] => Von Frey Électronique - Sans Fil
                    [description_short] => 
Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1859-electronic-von-frey-4.html
                )

            [1860] => Array
                (
                    [name] => Von Frey Électronique 5 avec caméra intégrée
                    [description_short] => 

En tant que version électronique du classique esthésiomètre à filaments de Von Frey, la dernière évolution de l’instrument électronique Von Frey de Bioseb, conçu pour déterminer le seuil de sensibilité mécanique chez les rongeurs (rats et souris) par stimulation sous la patte, est un outil indispensable pour vos recherches sur l’hyperalgésie et l’allodynie. En mesurant et en enregistrant la force à laquelle l’animal présente un réflexe de retrait de la patte, il est possible d’étudier les pathologies liées à la réponse sensorielle ainsi qu’à l’hyper- ou l’hypoesthésie.
L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1860-electronic-von-frey-5-with-embedded-camera.html
                )

        )

)
1