Publications

Dernière publication 01/02/2015

A three-dimensional self-opening intraneural peripheral interface -SELINE-

Objective. In this study we present the development and testing in a rat model of the self-opening neural interface (SELINE), a novel flexible...

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    [title] => A three-dimensional self-opening intraneural peripheral interface -SELINE-
    [paragraph] => A three-dimensional self-opening intraneural peripheral interface (SELINE)
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Authors
Cutrone A, Valle JD, Santos D, Badia J, Filippeschi C, Micera S, Navarro X, Bossi S.

 Lab
The Biorobotics Institute, Scuola Superiore Sant'Anna, Pontedera (PI), Italy.
Journal
J Neural Eng.
Abstract
Objective. In this study we present the development and testing in a rat model of the self-opening neural interface (SELINE), a novel flexible peripheral neural interface. Approach. This polyimide-based electrode has a three-dimensional structure that provides an anchorage system to the nerve and confers stability after implant. This geometry has been achieved by means of the plastic deformation of polyimide. Mechanical and electrochemical characterizations have been performed to prove the integrity of the electrode with very good results. Functionality of SELINEs for fascicular stimulation has been tested during in vivo acute experiments in the rat. Chronic implants were made to test the biocompatibility of the device. Main results. Results showed that SELINEs significantly improve mechanical anchorage to the nerve. Stimulation stability is considerably enhanced compared to common planar transversal electrodes and stimulation selectivity is increased for some motor fascicles. Chronic experimental results showed that SELINEs neither produce changes in the fascicular organization of sciatic nerves nor signs of nerve degeneration. Significance. The presented three-dimensional electrode provides an effective anchorage system to the nervous tissue that can improve the stability of the implant for acute and chronic studies.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
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Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

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L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

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