Autres pathologies - page 3 - Publications Scientifiques

Dernière publication 17/02/2025

Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect

A study was conducted to evaluate the three-dimensional clinostat simulated microgravity effect on mouse models, focusing on the central nervous...

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    [title] => Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect
    [paragraph] => Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect in mice focusing on the central nervous system
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Authors
Zhou, Li, Song, Chenchen, Yang, Hu, Zhao, Lianlian, Li, Xianglei, Sun, Xiuping, Gao, Kai, Guo, Jianguo

 Lab

Journal
Scientific Reports
Abstract
A study was conducted to evaluate the three-dimensional clinostat simulated microgravity effect on mouse models, focusing on the central nervous system. Eighteen mice were divided into three groups: control, survival box, and clinostat + survival box. Behavioral tests, femur micro-CT, brain transcriptomics, serum metabolomics, and fecal microbiomics were performed. Results showed decreased activity, altered gait, enhanced fear memory, bone loss, immune/endocrine changes in brain transcriptome, and altered metabolic pathways in serum and gut microbiota in clinostat-treated mice. The model closely mimics spaceflight-induced transcriptome changes, suggesting its value in studying microgravity-related neurological alterations and highlighting the need for attention to emotional changes in space.
Keywords/Topics
Microgravity; Three-dimensional clinostat; Brain; Transcriptomics; Microbiomics; Serum metabolomics; Animal model; Environmental impact; Neuroscience; Physiology; Risk factors; Zoology
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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