Publications

Dernière publication 14/12/2023

BACH1 changes microglial metabolism and affects astrogenesis during mouse brain

Summary Microglia are highly heterogeneous as resident immune cells in the central nervous system. Although the proinflammatory phenotype of...

Array
(
    [id_prestablog_news] => 2346
    [id_shop] => 1
    [date] => 2023-12-14 00:00:00
    [date_modification] => 2023-12-14 00:00:00
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 4538
    [id_lang] => 2
    [title] => BACH1 changes microglial metabolism and affects astrogenesis during mouse brain 
    [paragraph] => BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development
    [content] => 
Authors
Yanyan Wang, Wenwen Wang, Libo Su, Fen Ji, Mengtian Zhang, Yanzhen Xie, Tianyu Zhang, Jianwei Jiao

 Lab

Journal
Developmental Cell
Abstract
Summary
Microglia are highly heterogeneous as resident immune cells in the central nervous system. Although the proinflammatory phenotype of microglia is driven by the metabolic transformation in the disease state, the mechanism of metabolic reprogramming in microglia and whether it affects surrounding astrocyte progenitors have not been well elucidated. Here, we illustrate the communication between microglial metabolism and astrogenesis during embryonic development. The transcription factor BTB and CNC homology 1 (Bach1) reduces lactate production by inhibiting two key enzymes, HK2 and GAPDH, during glycolysis. Metabolic perturbation of microglia reduces lactate-dependent histone modification enrichment at the Lrrc15 promoter.The microglia-derived LRRC15 interacts with CD248 to participate in the JAK/STAT pathway and influence astrogenesis. In addition, Bach1cKO-Cx3 mice exhibit abnormal neuronal differentiation and anxiety-like behaviors. Altogether, this work suggests that the maintenance of microglia metabolic homeostasis during early brain development is closely related to astrogenesis, providing insights into astrogenesis and related diseases.

Keywords/Topics
BACH1 ;microglia; metabolism ;astrogenesis; histone; lactylation; LRRC15 I
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
    [meta_description] => 
    [meta_keywords] => https://www.cell.com/developmental-cell/fulltext/S1534-5807(23)00616-0
    [meta_title] => 
    [link_rewrite] => BACH1-changes-microglial-metabolism-and-affects-astrogenesis-during-mouse-brain-development
    [actif_langue] => 1
    [read] => 82
    [count_comments] => 0
    [id] => 2346
    [categories] => Array
        (
            [77] => Array
                (
                    [id_prestablog_categorie] => 77
                    [title] => Métabolisme général
                    [link_rewrite] => Metabolisme-general
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Test d'agrippement
                    [description_short] => 
Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/activite-systeme-moteur-coordination/48-grip-strength-test.html
                )

        )

)
1