Système sensoriel - page 4 - Publications Scientifiques

Dernière publication 24/05/2011

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel e

Cold hypersensitivity is the hallmark of oxaliplatin-induced neuropathy, which develops in nearly all patients under this chemotherapy. To date,...

Array
(
    [id_prestablog_news] => 321
    [id_shop] => 1
    [date] => 2011-05-24 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 638
    [id_lang] => 2
    [title] => Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel e
    [paragraph] => Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. 
    [content] => 
Authors
J. Descoeur, V. Pereira, A. Pizzoccaro, A. Francois, B. Ling et al. (Team of Dr Bourinet) 

 Lab
Institut de Génomique Fonctionnelle, CNRS, UMR-5203, Département de Physiologie, Montpellier, France.
Journal
EMBO Molecular Medicine
Abstract
Cold hypersensitivity is the hallmark of oxaliplatin-induced neuropathy, which develops in nearly all patients under this chemotherapy. To date, pain management strategies have failed to alleviate these symptoms, hence development of adapted analgesics is needed. Here, we report that oxaliplatin exaggerates cold perception in mice as well as in patients. These symptoms are mediated by primary afferent sensory neurons expressing the thermoreceptor TRPM8. Mechanistically, oxaliplatin promotes over-excitability by drastically lowering the expression of distinct potassium channels (TREK1, TRAAK) and by increasing the expression of pro-excitatory channels such as the hyperpolarization-activated channels (HCNs). These findings are corroborated by the analysis of TREK1-TRAAK  mice and use of the specific HCN inhibitor ivabradine, which abolishes the oxaliplatin-induced cold hypersensibility. These results suggest that oxaliplatin exacerbates cold perception by modulating the transcription of distinct ionic conductances that together shape sensory neuron responses to cold. The translational and clinical implication of these findings would be that ivabradine may represent a tailored treatment for oxaliplatin-induced neuropathy.
BIOSEB Instruments Used
Cold Hot Plate Test (BIO-CHP),Thermal Gradient Test (BIO-GRADIENT),Thermal Place Preference, 2 Temperatures Choice Nociception Test (BIO-T2CT),Jump Test (BIO-JTET)
    [meta_description] => 
    [meta_keywords] => http://onlinelibrary.wiley.com/doi/10.1002/emmm.201100134/abstract
    [meta_title] => 
    [link_rewrite] => oxaliplatin-induced-cold-hypersensitivity-is-due-to-remodelling-of-ion-channel-expression-in-nociceptors--
    [actif_langue] => 1
    [read] => 1081
    [count_comments] => 0
    [id] => 321
    [categories] => Array
        (
            [90] => Array
                (
                    [id_prestablog_categorie] => 90
                    [title] => Cancer
                    [link_rewrite] => Cancer
                )

            [10] => Array
                (
                    [id_prestablog_categorie] => 10
                    [title] => Douleur
                    [link_rewrite] => Douleur
                )

            [29] => Array
                (
                    [id_prestablog_categorie] => 29
                    [title] => Douleurs neuropathiques
                    [link_rewrite] => Douleurs-neuropathiques
                )

            [48] => Array
                (
                    [id_prestablog_categorie] => 48
                    [title] => Perception du chaud et du froid
                    [link_rewrite] => Perception-du-chaud-et-du-froid
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [13] => Array
                (
                    [id_prestablog_categorie] => 13
                    [title] => Système sensoriel
                    [link_rewrite] => Systeme-sensoriel
                )

            [24] => Array
                (
                    [id_prestablog_categorie] => 24
                    [title] => Thématiques transversales
                    [link_rewrite] => Thematiques-transversales
                )

        )

    [authors] => 
    [paragraph_crop] => Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [563] => Array
                (
                    [name] => Plaque froid et chaud
                    [description_short] => 
Instrument de test de la sensibilité de l'animal à la douleur résultant de l'exposition à la chaleur ou au froid: la plaque froid et chaud de Bioseb est un instrument innovant ouvrant de nouveaux champs d'investigation pour vos recherches en analgésie et nociception, et un outil efficace pour le screening de substances analgésiques basé sur les modèles de rat ou souris.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-thermique/563-cold-hot-plate-test.html
                )

            [897] => Array
                (
                    [name] => Préférence de Place Thermique : Test de Choix entre 2 Températures
                    [description_short] => 
Un test indépendant de l'opérateur pour étudier les seuils de douleur chez les rongeurs (rats et souris) par l'évaluation de la préférence de température (zone de confort thermal) - un outil innovant pour vos recherches sur l'analgésie et la nociception, ouvrant de nouveaux champs d'étude, et une solution idéale pour le screening de médicaments analgésiques et nociceptifs. Désormais fourni avec un nouveau logiciel dernier cri permettant de monitorer l'activité et les transitions de température rapides!

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-thermique/897-thermal-place-preference-2-temperatures-choice-nociception-test.html
                )

            [1637] => Array
                (
                    [name] => Jump Test - Test de saut
                    [description_short] => 
Le "Jump Test", ou "Test d'échappement par le saut", est un nouveau système d'évaluation du comportement d'échappement des souris soumises à une rampe de températures chaudes et froides sur une plaque d'aluminium: il permet de différencier l'allodynie thermique de l'hyperalgésie dans les modèles de sensibilisation à la douleur périphérique chez la souris. Un outil indispensable pour vos recherches an analgésie, en particulier pour mesurer les effets pharmacologiques des traitements anti-cancer, y compris les neuropathies induites par la chimiothérapie.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-thermique/1637-jump-test.html
                )

        )

)
1